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Biomedical subjects

D Ciepielewska

Publications and source records attributed to D Ciepielewska.

At least 37 records · Page 2Linked to original sources
PubMed1976

Autoimmune haemolytic anaemia in children.

Forty-four children with autoimmune haemolytic anaemia (AIHA) are described: 31 had acute, subacute or chronic disease with warm autoantibodies and 13 had acute or chronic anaemia with cold autoantibodies. The commonest forms were the acute and subacute types with warm autoantibodies and these were more frequent in young children, while chronic AIHA occurred mainly among children at puberty. In about 16% the anaemia was accompanied by a chronic disorder but in over 50% the anaemia was preceded by an acute infection or immunization. The former gave rise mainly to chronic anaemia, but the latter was associated with the acute and subacute forms. In general the prognosis was good and death was never caused by anaemia per se. The prognosis was worse in patientw with clinical features of thrombocytopenia and bleeding and with the immunological findings of free autoantibodies in the serum and a positive direct antiglobulin test. In acute and subacute forms, treatment with corticosteroids and sometimes with blood transfusions was effective. In chronic forms of the disease it was often necessary to give additional immunosuppressive drugs or/and to perform a splenectomy.

Acute Disease↗
PubMedDate not supplied

[Thiotepa in the treatment of central nervous system leukemia in children].

The authors report beneficial effects of thiotepa on leukaemic involvement of the central nervous system. The drug was given to 4 children with central nervous system leukaemia refractory to methotrexate and cytarabine. Intrathecal thiotepa caused regression of changes in the cerebrospinal fluid and in the neurological status of these children. No side effects were observed during this treatment.

Age Factors↗
PubMedDate not supplied

Salmonelloses in children with proliferative haematological diseases.

The infections caused by salmonella organisms in children with acute leukaemias are reported. Immunity depression caused by the main diseases as well as by immunosuppressing drugs lead in such cases to generalized infections with these organisms or local infections which were found in the reported cases in the skeletal system, or central nervous system. The course of these infections was very severe, often with lethal outcome.

Acute Disease↗