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Biomedical subjects

D Chen

Publications and source records attributed to D Chen.

At least 901 records · Page 50Linked to original sources
PubMed1974

The antibody response to sporozoites of simian and human malaria parasites: its stage and species specificity and strain cross-reactivity.

Attempts to vaccinate against malaria are currently being pursued in both simian hosts and human volunteers, using X-irradiated sporozoites as antigen. The present experiments provide information on the developmental stage during which simian malaria sporozoites acquire certain antigen(s) and become infective, and on the antigenic similarities between sporozoites of different strains and species of simian and human malaria parasites. Such knowledge should prove of value in the choice of sporozoite preparations for future attempts at vaccination.

Animals↗
PubMed1972

Onset of deoxyribonucleic Acid synthesis in germinating wheat embryos.

Germinating wheat embryos (Triticum vulgare var. Florence) synthesize proteins before the onset of DNA synthesis. The onset of DNA replication occurs at about 15 hours of germination and was shown to depend on proteins synthesized before 9 hours of germination with the use of blasticidin S, a specific inhibitor of protein synthesis. A 10-fold increase in the activity of DNA-dependent DNA polymerase was found in extracts derived from germinated embryos, as compared to the activity found in extracts from ungerminated embryos.

Journal Article↗