Search PubMed⌕ Search

Biomedical subjects

D Charpin

Publications and source records attributed to D Charpin.

168 records · Page 10Linked to original sources
PubMedDate not supplied

Prevalence of allergy to Hymenoptera stings.

In this study, we evaluated the prevalence of systemic reactions to hymenoptera stings in an adult general population, 20-60 years old. The protocol included a standardized questionnaire, skin tests to venom in subjects reporting a history of systemic reaction, and in subjects reporting a history of severe local and systemic reactions, as well as in a control group, a radioallergosorbent test (RAST) to hymenoptera venoms. According to the questionnaire, 1.2% of the study population had a history of systemic reactions. Only 0.85% had both such a history and a positive skin test to venoms. RASTs were positive, for at least one venom, in 57% of subjects with a history of systemic reaction, 15.8% of subjects with a history of severe local reactions, and 6.0% of the control group. In conclusion, this study shows that systemic reactions are not uncommon in the general population. RASTs tests are not sensitive or specific enough to be considered, per se, for indications of allergy to venoms.

Adult↗
PubMedDate not supplied

Atopy and systemic reactions to hymenoptera stings.

To evaluate whether atopy is a risk factor for systemic reactions to hymenoptera stings, we compared the atopic status of two groups of subjects. The first group included 93 patients (59 males), mean (+/- SD) age: 42.3 +/- 17.2 yrs with a history of anaphylactic reactions to hymenoptera stings. The second was a control group of 712 subjects (379 males), mean (+/- SD) age: 42.0 +/- 9.6 years recruited at a public health care center. The protocol included a standardized questionnaire about symptoms suggestive of atopy, i.e. medical diagnosis of asthma, perennial rhinitis or hay fever, and skin tests to common aeroallergens, i.e. house dust mites, cat danders, and grass pollens. The percentage of subjects with atopic symptoms was comparable in the two groups (32.2% for the patient group and 28.5% for the control group). Similarly, 22.6% of patients and 36.8% of controls exhibited at least one positive skin prick test. Lastly, 15.1% of patients and 18.5% of controls (a nonsignificant difference) had at least one symptom of atopy and at least one positive skin test. These findings show that atopy is not a risk factor for systemic reactions to hymenoptera stings.

Adult↗
PubMedDate not supplied

Dose-response curves to inhaled carbachol in asthma and chronic bronchitis.

Dose-response curves were established in 19 asthmatic and 19 bronchitic patients by measuring changes in specific airway resistance (sRaw) induced by graded doses of aerosolized carbachol. The shape of the individual curves was classified by the least-square method according to four models: hyperbolic, exponential, linear and logarithmic (with a plateau). The dose-response curves were hyperbolic in 9 asthmatics, exponential in 9, and linear in 1; they were hyperbolic in 2 bronchitics, exponential in 4, linear in 5 and logarithmic in 5. No response could be elicited in 3 bronchitics. Carbachol responsiveness of the bronchitics who had baseline sRaw values in the same range as the asthmatics was much less than that of the asthmatics, i.e. a given dose of carbachol yielded a smaller sRaw increase in the former group. Increased responsiveness to carbachol, resembling that found in the asthmatic group, was observed in most bronchitics whose baseline sRaw values were elevated. These data suggest that bronchitics and asthmatics have different bronchial responses to carbachol, quantitatively and, in some instances, qualitatively.

Adolescent↗
PubMedDate not supplied

[Immediate and secondary prognosis of suffocation fits from post-tuberculous respiratory insufficiencies (author's transl)].

Prognosis for an immediate future and up to one year of decompensation periods was comparable both in chronic bronchitic patients and in ancient tuberculous ones. The latter can be divided in two groups, "amputated" and "non-amputated", according to the main kind of sequellae, pleural and/or parenchymatous. The immediate future is identical and then, the prognosis of the "amputated" which was rather more favourable at one year progressively worsens to reach that of "non-amputated" patients.

Adult↗