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Biomedical subjects

D Chadenas

Publications and source records attributed to D Chadenas.

22 records · Page 2Linked to original sources
PubMed1985

[Plasma exchange and hyperthyroidism. Current indications].

Serious thyrotoxicosis must be treated quickly and efficiently. Plasma exchange (PE) takes place when ordinary treatment is not suitable in emergency cases. Several methods of plasma clearing have already been practiced successfully. PE is the best one. It quickly removes a great amount of thyroid hormones and occasionally pathological immunoglobulins. Risks have not to be underestimated. The most serious accidents are particularly linked with the substitution fluids. Hemoperfusion, peritoneal dialysis, transfusion exchanges can be used too. Thyrotoxicosis crisis, as far as life prognosis is concerned, is an appropriate indication of PE, either as a first line treatment or after the classical treatment has failed. Serious hyperthyroidism due to iodine overload is not improved with common treatment. In this case PE might be worthwhile. In malignant exophthalmia, unimproved with an usual treatment PE can be successfully used, every time ocular prognosis is concerned.

Graves Disease↗
PubMedDate not supplied

[Paresthetic notalgia and multiple endocrine neoplasia type 2a (Sipple's syndrome): 3 cases].

INTRODUCTION: Notalgia paresthetica is an isolated sensory mononeuropathy. Patients have a pruritus in the mid-upper back. Its association with multiple endocrine neoplasia type IIA has been reported in a few cases. We report three cases of this association. CASE REPORTS: Case n(o) 1: A 45 year-old woman had multiple endocrine neoplasia type IIA with a medullary thyroid carcinoma and a primary hyperparathyroidism; she had a mid-upper back pigmented lesion. Histological examination showed dermal melanosis and deposits of amyloid in the dermis. Case n(o) 2: A woman had a multiple endocrine neoplasia type IIA which was diagnosed at the age of 60; she had a surgical treatment for a pheochromocytoma, a medullary thyroid carcinoma, and a primary hyperparathyroidism; she had dermatological examination for a pruriginous lesion of the mid-upper back. Case n(o) 3: The daughter of the patient n(o) 2 had had a surgical cure for a medullary thyroid carcinoma and a pheochromocytoma at the age of 31; she had a papulous and pruriginous lesion in the left scapular area. Her daughter and her sister had a multiple endocrine neoplasia type IIA without notalgia paresthetica. DISCUSSION: Notalgia paresthetica is a benign cutaneous disorder which can be associated with multiple endocrine neoplasia type IIA. It can be considered that notalgia paresthetica is an early clinical marker of multiple endocrine neoplasia type IIA. Patients with a familial history of notalgia paresthetica or with an onset of notalgia paresthetica in childhood should be screened for multiple endocrine neoplasia type IIA. Patients with multiple endocrine neoplasia must also been screened for notalgia paresthetica because its finding is an argument for a familial form of multiple endocrine neoplasia type IIA. Dermatologists should be aware of this association.

Adrenal Gland Neoplasms↗
PubMedDate not supplied

[Somatostatinomas].

Somatostatinomas are endocrine tumors which prevailing secretion is somatostatin. They are localized in the pancreas and digestive tract or not often in tissues unusually secreting somatostatin, as bronchi. Forty three cases have been described until now. The endocrine syndrome, not very spécific and inconstant, is the result of the somatostatin hypersecretion. Diabetes mellitus, cholelithiasis, pancreatic exocrine insufficiency, gastric hypochlorhydria and anemia are the main symptoms of pancreatic somatostatinoma. On the other hand, they are not found in digestive tumors. Somatostatinomas often secrete other hormonal peptides which may change the clinical manifestations. Radioimmunoassay of plasma somatostatin (basal level and/or after stimulation by tolbutamid) is a more successful diagnostic test; but only immunocytochemistry of the tumor can proved the diagnosis. They a bad prognosis but are not a contra-indication to make a curative treatment; surgical resection and chemotherapy by streptozotocin and 5 FU are the two treatments.

Adenoma, Islet Cell↗