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Biomedical subjects

D Cerimele

Publications and source records attributed to D Cerimele.

At least 73 records · Page 4Linked to original sources
PubMed1985

High prevalence of cardiovascular diseases and enhanced activity of the renin-angiotensin system in psoriatic patients.

We have observed a significant higher prevalence of essential hypertension, cardiovascular diseases and diabetes in a group of 100 psoriatic patients compared with sex and age matched hospitalized controls. Thirty-five psoriatic patients exhibited and enhanced plasma renin activity (PRA), while urinary aldosterone excretion was raised in 27% of the group. The autonomic responsiveness of psoriatic patients, studied by cold pressure test and tilting was normal; this finding supports the hypothesis that the enhanced activity of renin-angiotensin system is not due to an increased sympathetic function in these psoriatic patients. High values of cholesterol, triglycerides and depressed HDL-cholesterol concentrations were also observed. A complete clinical and laboratory examination is very useful in psoriasis in order to initiate an appropriate treatment of the risk factors whenever present.

Aldosterone↗
PubMed1984

HLA and Kaposi's sarcoma in Sardinia.

Twelve Sardinian patients affected by histologically defined classic Kaposi's sarcoma (KS) were HLA-A, B, C and DR typed. Compared to 220 age and ethnically matched healthy controls, KS patients showed a significant increase in HLA-DR5 (66.6 vs 23.1%, P less than 0.001) and a considerable decrease in HLA-DR3 (8.3 vs 53.6%, P = 0.0055). No definite association was observed for other HLA antigens. These results confirm the existence of an HLA associated genetic control of KS susceptibility and support the hypothesis that HLA-DR5 plays the role of a predisposition marker while HLA-DR3 bears a genetic resistance to the disease.

Aged↗
PubMed1983

[Anti-cytomegalovirus antibodies in Kaposi's sarcoma].

16 patients with Kaposi's Sarcoma were examined with in vitro tests for cellular immunity and with determination of antibody titres to Cytomegalovirus. It was stated that the Cytomegalovirus antibodies were related with new viral infections favoured by the immunosuppression.

Aged↗
PubMed1982

Clonal structural chromosomal rearrangements in primary fibroblast cultures and in lymphocytes of patients with Werner's Syndrome.

The cytogenetics of six cases of adult progeria (Werner's syndrome) from three Sardinian families were investigated. The overall increased incidence of chromosome breakage found in cultured lymphocytes and fibroblasts seems to be age-dependent. The occurrence of clonal variegated translocation mosaicism, previously found by other authors in fibroblast cell lines derived from Werner patients was demonstrated also in fibroblasts analyzed in situ on the outgrowth halos from primary skin explants; a strong indication that these aberrations are present in the in vivo precursors. The same type of clonal structural aberration was found for the first time also in 72h-cultured lymphocytes. These findings demonstrate that Werner's syndrome is indeed a further example of a chromosome rearrangement syndrome.

Adult↗
PubMed1982

High prevalence of Werner's syndrome in Sardinia. Description of six patients and estimate of the gene frequency.

Several patients with Werner's syndrome in a large family group in Sardinia were ascertained three years ago and reported briefly by Rabbiosi and Borroni (1979). Since then two sisters from a second family and a single case from a third family were ascertained. The three families originated from the Northern part Sardinia and no connection between them was found. We provide a detailed clinical description of six of these patients and attempt to estimate the prevalence and the gene frequency of Werner's syndrome in Sardinia. The prevalence was calculated as 1:94,914 for the two districts of Sassari and Nuoro and as 1:202,766 for the whole island. This is the highest prevalence thus far ascertained. Using Dahlberg's formula we obtained an estimate of the gene frequency q = 0.003288 and thus a frequency of Werner's syndrome of 1:92,515. A more rigorous estimate gave a gene frequency q = 0.001483 and thus a frequency of Werner's syndrome of 1:454,505, but because of the small sample size this estimate should be taken with caution.

Adult↗
PubMed1979

Acid mucopolysaccharides of the dermis in incipient psoriasis.

Acid mucopolysaccharides have been studied in the dermis of 40 cases of incipient psoriasis. In the upper dermis a marked reduction of the material stained with colloidal iron and with Alcian blue solutions containing 0.1 and 0.2 M MgCl2 was observed; enzymatic controls with hyaluronidase support the idea that this material consists mainly of hyaluronic acid. The intensity and the extension of this dermal alteration far beyond the limits of the above-mentioned epidermal alteration give credence to the hypothesis that in the pathogenesis of psoriasis, dermal alterations are of a primitive character.

Alcian Blue↗
PubMed1978

Histochemistry of the dermal ground substance of initial psoriatic lesions.

30 cases of initial psoriasis were studied. Pinhead-sized lesions, recently appeared, were excised and studied with histochemical methods for acid mucopolysaccharides. In all specimens a well defined reduction of the material stained with colloidal iron, with alcian blue with critical electrolyte concentrations and with toluidine blue was observed in the upper dermis, in particular in the papillary dermis in the center of the lesions, in correspondence of the squirting papillae. The more evident reduction of the staining with alcian blue with 0.1 M and 0.2 M MgCl2 suggests that the changes of the dermal ground substance are predominantly due to an alteration of the hyaluronic acid.

Alcian Blue↗
PubMed1978

Histochemistry of the intercellular substance of the normal and psoriatic human epidermis.

The intercellular substance of skin samples obtained from normal subjects and from psoriatic patients has been studied with histochemical methods for carbohydrate containing substances and checked with enzymatic extractions. The surface coat which makes up most of the intercellular substance was stained with colloidal iron and with Alcian Blue solutions containing up to 0.20 M magnesium chloride; the stainings were heavily affected by the previous treatment of the sections with testicular hyaluronidase, but not with neuraminidase. The staining of the intercellular substance with Alcian Blue solutions containing up to 0.20 M magnesium chloride and the action of the hyaluronidase gives strength to the hypothesis that hyaluronic acid is contained in the substance. In the skin of psoriatic patients intercellular spaces wider than in normal skin and a reduced surface coat, particularly in the higher layers, has been observed.

Carbohydrates↗
PubMed1978

[Polymorphous Juvenile Acne (author's transl)].

Many factors may be involved in the pathogenesis of acne, the most important of them lie in the sebaceous follicle, in disturbances of the cornification of the follicular channels and in the bacterial flora of the hair follicles. The latter consists of a yeast (pityrosporon ovale), coagulase-negative aerobic staphylococci and propionibacterium acnes. P. acnes is found in the depth of the follicle. It is of particular importance for the pathogenesis because it produces a lipase which releases fatty acids which stimulate the formation of comedones. Many questions are still unanswered. Presently, treatment consists of administration of estrogens or combination preparations of estrogen and progesterone (only recommended for women), of vitamin A acid and antibiotics. Tetracycline and its derivatives have proved particularly valuable for this purpose.

Acne Vulgaris↗