Search PubMed⌕ Search

Biomedical subjects

D Cavanagh

Publications and source records attributed to D Cavanagh.

At least 289 records · Page 16Linked to original sources
PubMed1968

Secondary amenorrhea.

Explore the source record for details and available documents.

Adrenal Hyperplasia, Congenital↗
PubMed1966

Carcinoma of the cervix among women in their twenties. A 14% prevalence deserves our respect!

The purpose of this study was to estimate the value of routine vaginal cytology in women under 30 years of age. Over a five-year period, 18,160 vaginal cytological examinations were made on women aged 20 through 29 years, and 424 women (2.3%) were found to have Papanicolaou smears class III, IV, or V. Of these 424 patients, 122 (28.8%) were found to have carcinoma of the cervix. A tissue diagnosis of intraepithelial carcinoma was obtained in 103 women. The remaining 19 patients proved to have invasive carcinoma of the cervix. Approximately one third of this group of women with positive cytology failed to return for tissue diagnosis so the true prevalence of cancer was probably in the region of 40%. The findings suggest that women deserve routine vaginal cytological examinations irrespective of age.

Adolescent↗
PubMed1966

Septic shock.

Explore the source record for details and available documents.

Adult↗
PubMedDate not supplied

Recent advances in avian virology.

Selected, recent research on the following avian diseases, and their causative viruses, has been reviewed: chicken anaemia, infectious bursal disease, turkey rhinotracheitis, avian nephritis, fowlpox, influenza, infectious bronchitis and turkey enteritis.

Animals↗
PubMedDate not supplied

Hormonal modulation of Ishikawa cells during three-dimensional growth in vitro.

OBJECTIVES: The Ishikawa endometrial cancer cell line is hormonally responsive, expressing estrogen and progesterone receptors (ER, PR) when grown in traditional monolayer culture. The purpose of this paper is to demonstrate a three-dimensional spheroid culture system for cancer cells. We used this system to determine the response of the Ishikawa cell line to estradiol-17 beta (E), tamoxifen (T), megestrol acetate (MA), and progesterone (P). METHODS: Ishikawa cells were incubated in polyurethane culture bags using phenol red-free media containing ethanol (0.1%, controls), E (1 mumol, or 1 nmol), T (1 mumol, or 10 nmol), MA (1 mumol, or 10 nmol), or P (1 mumol). Cellular morphology was assessed by hematoxylin and eosin staining, and expression of estrogen and progesterone receptors was determined immunohistochemically using an immunoperoxidase technique. RESULTS: Cells in control cultures demonstrated minimal organization and lacked hormone receptors. In contrast, cells exposed to either E or T displayed significant glandular formation, with multicellular, microvilli-rich, columnar epithelia exhibiting polarized nuclear arrangements. Within 4 weeks, E- and T-treated cultures showed upregulated nuclear staining for PR, with little ER present. Cells treated with MA or P showed less glandular organization but expressed ER with PR downregulation. CONCLUSIONS: These data support the use of this novel three-dimensional culture system to study the modulation of tumor cell biologic activity in response to hormonal agents. Future applications of this model include examining in vitro responsiveness of cancer cell lines to additional biologic agents and chemotherapeutic regimens.

Cell Culture Techniques↗