[Effects of nifedipine on the blood concentration and urinary excretion of electrolytes and hormones in normal subjects].
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Adult↗
Biomedical subjects
D Castro
Publications and source records attributed to D Castro.
MR-guided aspiration cytology in the head and neck at high field strength.
Published reports of magnetic resonance (MR)-guided needle biopsy have involved low- and mid-field-strength systems because of the concern of needle artifact and risk of increased needle torque at higher field strengths. To the authors' knowledge, this is the first report of a high-field-strength (1.5-T) system used to guide aspiration cytology in the head and neck in a patient. The procedure was successfully accomplished without additional needle torque or substantial increase in image artifact relative to lower-field-strength imaging.
Biopsy, Needle↗
Necrotizing lesions of soft tissues: a review.
Necrotizing lesions of the soft tissues are grave entities not infrequently seen in daily surgical practice. They may occur with epidemic proportions after natural disasters, representing a serious challenge to the surgeon since they are characteristically associated with high mortality rates unless an early diagnosis is made and prompt aggressive surgical management is initiated. Necrotizing fasciitis is the currently accepted generic term to encompass into a single category the diverse syndromes of progressive gangrenous infections of the skin and subcutaneous tissues. Necrotizing fasciitis must be viewed as a clinical entity rather than a specific type of infection: it is a clinical infection most commonly caused by a mixed aerobic/anaerobic synergistic polymicrobial combination. Zygomycetes may appear as major causal organisms (mucormycosis) and they should be actively searched for. Initial diagnosis of necrotizing fasciitis is established through the characteristic physical signs. Gram stain, and, in some doubtful cases, through frozen-section tissue biopsy. Aggressive and urgent radical debridement is the key to survival, combined with wide-spectrum antibiotic therapy.
Fasciitis↗
Necrotizing soft tissue lesions after a volcanic cataclysm.
A volcanic cataclysm of major proportions, the fourth largest in terms of total casualties in the history of mankind, wiped out the town of Armero, Colombia, in 1985 resulting in over 23,000 deaths and 4,500 wounded. Among the hundreds of survivors who were transferred to hospitals in the capital city of Bogotá, there was as overwhelming number who developed necrotizing fasciitis. These patients constitute, perhaps, the single largest group of this type of lesions in the recorded literature. Thirty-eight patients with well established necrotizing fasciitis were identified at 4 selected hospitals in Bogotá; 8 of them presented with zygomycetic infection (mucormycosis), a highly lethal entity. Many additional cases were treated at other hospitals in Bogotá and several cities in Colombia. The main clinical features of these 38 patients affected by necrotizing fasciitis are reviewed, with special emphasis on the patients with mucormycosis. Patients with necrotizing fasciitis had an overall mortality rate of 47.7%; patients with mucormycosis, 80%. A plea is made for an early diagnosis, utilizing tissue sampling and microbiological studies, so that prompt and radical treatment can be instituted. This is especially pertinent in situations of natural disasters resulting in massive numbers of casualties and seriously injured survivors.
Amputation, Surgical↗
Intelligent telemonitoring of critical-care patients.
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Computer Systems↗
[Intestinal amebiasis in Antofagasta, Chile].
In January 1989--December 1991 period we verified 35 cases of symptomatic intestinal amebiasis in Antofagasta, the main city of the North of Chile. Out of the total number of studied patients 23 were adults (77.1% males and 22.9% females) and all of them were permanent residents of Antofagasta. E.histolytica was frequently detected in association with other parasites and/or commensals, and observed alone in only seven cases. The clinical and epidemiological aspects of these 35 cases are discussed.
Adolescent↗
[Endoscopic resection in early gastric cancer].
Development of therapeutic endoscopy has permitted the treatment of early gastric cancer (EGC) in its different macroscopic forms. In this paper we present 9 cases of EGC treated endoscopically in our Institution. We describe the criteria we follow to perform this procedure. The patients selected were of advanced age and high surgical risk. Seven cases were macroscopically Type I and two were Type IIa. According to localization six were proximal tumors (body and fundus) and three were located in the antrum. Six of the nine patients are alive after resection, one more than 6 years and 3 more than 3 years. Three patients died of ailments no related to cancer.
Aged↗
[Histologic study of Helicobacter pylori in 265 consecutive gastric biopsies].
We evaluated 265 consecutive endoscopic gastric biopsies of subjects attending the gastric cancer mass survey that is taken place in the State of Tachira, Venezuela. They were 152 males and 113 females between 18 and 70 years of age. We established the prevalence of Helicobacter pylori in relation with histologic diagnosis and location of the lesions in the stomach. We performed hematoxylin eosin, Giemsa and Gimenez stains. The bacteria was identified in chronic non atrophic gastritis in 81% of the cases, in 76% of erosive gastritis, in 72% of gastric ulcers, in 36% of chronic atrophic gastritis and in 16% of neoplastic tissues. Helicobacter pylori was found in 82% of antral biopsies, and in 9% of the body, 7% of the fundus and 2% of the cardiac biopsies. From the total of 265 biopsies HP was positive in 172. The prevalence of this bacteria was 69.9% in this investigation.
Adolescent↗
[Psychology and cancer: role of rationalization in cancerous disease of unfavorable prognosis (apropos of a clinical case)].
This text intends to tackle one of the aspects of psychosomatic interactions in cancer: the patient's irrational cognitions related to his trouble. The authors design as cognitive process (CP) the mental work implying the production and the evolution of personal cognitions bound to a personal event. In cancer, CP often drives the subject to adopt irrational points of view concerning his disease, which onset is readily described as a consequence of significant life events; in such explanations, the part of hazard is excluded. The authors suggest that spontaneous CP may be useful helping the patient to avoid strong depressive affects, to alleviate feelings of anger or despair and to improve self-esteem threatened by the illness. The authors consider that using CP concept may be an accurate tool in psychotherapy of patients suffering from cancer. Therapeutic strategies may tend to favour the CP development so that the subject's conceptions stabilize on an ego-syntonic level.
Attitude to Death↗
[Gastric cancer in hyperplasia polyps].
We present 3 cases of Early Gastric Cancer in 82 Hyperplastic Polyps (HP) resected endoscopically (3.6%) during the years 1985 to 1989, at the GI Cancer Center "Dr. Luis E. Anderson", San Cristobal, Venezuela. The diagnosis criteria followed were those of Nakamura, T and Nagayo T. This paper shows the possibility of malignant changes of these lesions, advising endoscopic resection of HP as a mean of treatment and in order to make a complete study of the polyps. We compare our data with existing bibliography, finding similitude in results.
Aged↗
[Metastasis to lymph nodes in early gastric cancer].
The presence of metastasis in lymph nodes is one of the most important aspects to be evaluated in Early Gastric Cancer (EGC). In this paper we analyze the presence of that kind of metastasis in 70 EGC, in 66 patients studied in our Institute and surgically treated at the Central Hospital of San Cristobal. We found 3 cases with metastasis to perigastric (regional) lymph nodes (N1) and one case with extra perigastric lymph nodes metastasis (N3), that signify 5.7% of the total of all cases. We established the relationship of these metastasis and the following variables: macroscopic type, localization, size, depth of invasion within the gastric wall and the histological variety of the lesions. We found that the type IIa + IIc, the lesions located in the fundus, bigger that 3 cm, with invasion reaching the submucosa and histological differentiated (intestinal type), were the most important characteristics related with the presence of metastasis to the lymph nodes in our EGC.
Humans↗
[Endoscopic polypectomy of the upper digestive tract].
From 1985 to 1987 we performed 82 endoscopic polipectomies in 80 patients. In this paper we refer the technics, epidemiological data and macro and microscopical findings of the resected specimens. Two patients with gastric cancer were treated in this way, these patients had formal surgical contraindication. In two patients in whom the endoscopic biopsies could not render a definitive diagnosis (cancer or atypical epithelium), the study of the resected tumor permitted the diagnosis of atypical epithelium, so two gastrectomies were avoided. Among our resected lesions we found 55 of inflammatory type, 6 adenomas and 7 atypical epithelium. We consider that this is a useful method for the diagnosis and treatment of some elevated lesions. Although this is not the treatment of choice for the elevated early cancer, it could be used to treat cancerous tumors in patients with high surgical risk.
Adult↗
[Asymptomatic stomach ulcer].
The purpose of this paper is to evaluate the frequency and some of the clinical and epidemiological characteristics of asymptomatic gastric ulcer, found in persons who attend the Center for Control of Gastrointestinal Cancer of San Cristóbal, Venezuela, as part of a gastric cancer mass screening program. 350 patients with active peptic ulcer were found, 176 duodenal and 174 gastric, diagnosed by means of endoscopy. Of the patients with gastric ulcers, 67 (38.5%) had no symptoms. This group of asymptomatic patients were analyzed regarding age, sex, place of residence, type of work and also the location of the ulcer and the histology. We conclude that this entity is frequent in our region that it is associated with agricultural workers and house wives. It is necessary to continue a prospective periodical evaluation of these patients in order to understand the natural history of the entity.
Adult↗
[A new method for the etiological diagnosis of human scabies].
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Adolescent↗
[Macroscopic and histopathological aspects of atypical gastric epithelium].
Atypical Epithelium is a localized lesion, which has histological and macroscopic findings similar to gastric cancer. In this paper we evaluated 44 cases of atypical epithelium studied and treated in our institute. We found 3 cases of atypical epithelium associated with early gastric cancer. That is 2.66% of the total of all cases. We established the relationship of these lesions and following variables: age, size, localization, macroscopic shape and intestinal metaplasia. We found atypical epithelium in patients older than 50 years old, most of then smaller than 2 cm., localized in antrum and body gastric, and macroscopically were slight elevated lesions. Histologically all of them had intestinal metaplasia.
Adenocarcinoma↗
[Gastric leiomyoblastoma. Histomorphologic and immunologic analysis of 3 cases].
We present three cases of Leiomioblastomas of stomach, diagnosed at the unit of Pathology of the Gastrointestinal Cancer Center "Dr Luis E. Anderson" -San Cristóbal-Táchira State Venezuela. The lesions are analyzed from the clinical, morphological and immunohistological points of view, utilizing Queratine and Vimentin techniques. This neoplasm is not frequent but it is interesting because its biologic behavior not always correspond to its histology-pattern.
Humans↗
[Endoscopic sphincterotomy experience at the Cancer Control Center].
Endoscopy Sphincterotomy is an important therapeutic procedure in the treatment of some biliary and pancreatic disorders. In this paper, we report our experience over this subject. In our patients the main indication to perform this procedure was common bile duct stones; they were 83% of the total cases. In those cases, 67% were residual stones after cholecystectomy by laparotomy and laparoscopy. We performed sphincterotomy in 33% of patients with gallbladders in situ. In five patients (7.57%), we made the diagnosis of Oddi's sphincter dysfunction taken in account clinical, biochemical an radiological findings. No manometric measurements were done. We found some unusual cases, such as: choledococele and Sump syndrome. In five patients we had complications, 3 of them bled and the other two developed edematous pancreatitis. All these complications were solved with medical treatment.
Adult↗
[The use of urea carbon 14 in breath tests as diagnostic method for Helicobacter pylori infections].
The Helicobacter Pylori has been indicated as a pathologic agent in the pathogenesis of antral gastritis, gastric and duodenal ulcers and probably in gastric cancer. Due to the high incidence of this infection in our place, we decided to look for a diagnostic method quick to perform, sensitive, reliable and no invasive. The breath test of 14C urea, based in the production of urea by the H. Pylori, represents this alternative. We have found, using does of 1 microCi, a high correlation with the diagnosis of H. Pylori by biopsies. We determined as negative less than 100 DPM, doubtful between 100 and 200 DPM and positive more than 200 DPM. The high pick of the curve keeps tight relation with the degree of infection. We checked this when we suppressed the H. Pylori with bismuth subsalicylate. The breath 14C Urea test showed high sensitivity (100%) and specificity (85.71%). We conclude that this breath test is an alternative way of diagnosing and follow up for H. Pylori infections. It is highly sensitive, reproducible and no invasive.
Adult↗