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D Castaing

Publications and source records attributed to D Castaing.

At least 163 records · Page 9Linked to original sources

[Liver trauma].

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Humans↗

Treatment of postshunt encephalopathy with secondary arterialization: an experimental study in the rat.

Secondary arterialization of the hepatic stump of the portal vein has been performed in rats 7 days after portacaval anastomosis (PCA) at a date when the electrocorticographic changes of postshunt encephalopathy were evident. A complete regression of encephalopathy ensued. This correlated with an increase in the weight of the liver and estimated hepatic blood flow. These results confirm the efficiency of liver arterialization, primary or secondary, in the treatment of postshunt encephalopathy. In the groups of rats studied in this experiment a significant correlation was always found among encephalopathy, liver weight: body weight ratio, and hepatic blood flow. This reinforces the hypothesis that a decrease in hepatic blood flow is the main factor in the generation of liver atrophy, decrease of hepatic function, and encephalopathy following portacaval shunt. Primary arterialization of the liver in humans has not gained much favor because of technical difficulties, a high mortality rate, and the absence of clear-cut evidence of its efficiency. Our results suggest that arterialization of the liver might better be kept as a secondary procedure for those cases in which encephalopathy develops after PCA.

Animals↗

[Echotomography in the study of Spigeli's lobe. Normal and pathologic aspects. Surgical therapeutic effects].

Ultrasonographic examination of the liver segment I, based on limiting vascular ans fissural elements, requires detailed knowledge of hepatic anatomical and organizational features. Findings are of two-fold interest for pre-operative assessment. Firstly, as a complement to essential arteriography it can establish the integrity of the segment when considering hepatectomy for liver tumors, and secondly it enables application of modifications in techniques for portocaval anastomoses. The data obtained can also assist diagnosis in cases of cirrhosis and Budd-Chiaris syndrome.

Humans↗

[Diagnostic value of selective angiography in the pancreatic affections (author's transl)].

A retrospective study of selective angiography of the coeliac axis and superior mesenteric artery was conducted in 60 patients having a pancreatic disease. The purpose of this study was to precise the frequency, the specificity and the diagnostic value of each radiological sign in malignant and non malignant pancreatic affection. In patients with cancer of pancreas, the best radiological sign are the presence of an arterial obstruction, an irregular arterial stenosis, a venous obstruction or a parenchymal hypervascularization. In patients with benign affections, the most significant signs are á regular arterial stenosis alore or associated with an arterial involvement or the association of at least two of the three following signs: regular arterial stenosis, arterial involvement and venous compression. Using this signs, a correct diagnosis can be done, a posteriori, in 82% of the malignant pancreatic affections and in 76% of the benign pancreatic disease.

Arteries↗

Surgical treatment of hepatocellular carcinomas in noncirrhotic liver: experience with 68 liver resections.

Hepatocellular carcinoma (HCC), although generally associated with cirrhosis, can also develop in a noncirrhotic liver. To study HCCs in noncirrhotic liver, their surgical management and prognosis, 68 patients with partial hepatectomy for this disease were analyzed. The liver, in all cases, appeared normal macroscopically at laparotomy, but in 13 cases (19%) it presented some slight histologic modifications, such as steatosis or portal fibrosis. Five patients had a fibrolamellar carcinoma. The mean diameter of the tumors was 8.8 cm. Sixteen patients (23.5%) were treated preoperatively by embolization or chemoembolization. Surgical procedures consisted in a major hepatectomy (three segments or more) in 72% of the cases. Operative mortality and morbidity were, respectively, 2.9% and 19.0%. The 1-, 3-, 5-, and 10-year survivals and the survivals without recurrence were 74%, 52%, 40%, and 26% and 69%, 43%, 33%, and 19%, respectively. Recurrence, which was in most cases intrahepatic, occurred in 39 of the 66 survivors (59%) and was treated by rehepatectomy in 12 cases, providing long survivals. These data justify extensive, aggressive surgery for HCCs in noncirrhotic liver and show the need for long-term follow-up to detect late recurrence, as surgery for recurrent disease prolongs survival.

Adolescent↗