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Biomedical subjects

D Casanova

Publications and source records attributed to D Casanova.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Secondary hyperparathyroidism: diagnosis of site of recurrence.

Persistent or recurrent hyperparathyroidism after total parathyroidectomy with forearm implant may be caused by hyperplastic grafted tissue, residual parathyroid tissue left in the neck or the presence of a supernumerary gland not found during surgery. A correct assessment of graft function is needed to localize the source of hormone excess and to avoid an unnecessary neck reoperation in cases of graft dependent hyperparathyroidism. In 12 patients with relapsing hyperparathyroidism after total parathyroidectomy with forearm implant, total ischemic blockade of the arm bearing the parathyroid graft produced a "transitory implantectomy" with a significant reduction of serum levels of intact PTH in those with graft hyperfunction. In 6 patients with proved supernumerary glands, total ischemia of the graft was not followed by significant changes in intact PTH. Hyperparathyroidism was reversed after surgical resection of the parathyroid implants in the 6 patients with positive responses to the ischemic maneuver. A repeat neck reoperation removing cervical or mediastinal supernumerary glands was followed by control of recurrent hyperparathyroidism in the 6 patients with a negative response to the ischemic blockade. Total ischemic blockade of the arm bearing the parathyroid graft is a valuable method for a correct assessment of graft function after total parathyroidectomy with forearm autotransplantation.

Adult↗
PubMedDate not supplied

Management of nevus spilus.

Nevus spilus is clinically defined as a pigmented skin lesion composed of a light brown macule on which darker, circumscribed macular or papular lesions appear at a later stage. Histologically, nevus cells have been found both in pigmented spots and in the background stain. Cases of transformation into melanoma have been reported in the literature and the excision of these lesions is therefore justified. We discuss surgical techniques used in seven patients with nevus spilus and define their indications with respect to the characteristics of the lesion.

Adult↗
PubMedDate not supplied

[Chronic osteomyelitis caused by Klebsiella pneumoniae with a 50 year course. Medicosurgical management].

The 50-year clinical course of a case of osteomyelitis of the left tibia is reported. Surgical specimens were positive for Klebsiella pneumoniae allowing treatment with certriaxone and ciprofloxacine. After antibiotic therapy, regional skin expansion was possible with excision and simultaneous closure of a wide area of damaged skin resulting from the long-term infection.

Anti-Infective Agents↗