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Biomedical subjects

D C Williams

Publications and source records attributed to D C Williams.

At least 235 records · Page 13Linked to original sources
PubMed1975

A cytogenetic study in women who had used oral contraceptives and in their progeny.

A study has been made of the chromosome numbers and characteristics of leucocytes cultured from mothers (a total of 77) who had taken one or more types of oral contraceptive, and their babies (108), and compared with similar numbers of control subjects. When the total cytogenetic results from test and control mothers were compared, no significant differences in frequency or type of chromosome abnormalities was observed. However, with certain types of oral contraceptive, minor differences in the numbers of chromosome abnormalities were found between test and control groups and the significance of these findings are discussed. The only significant abnormalities observed in the babies from mothers taking oral contraceptives were slight increases in the numbers who had cells with less than 46 chromosomes and who exhibited chromosomal gaps. The number of abnormal cells was significantly higher in babies born to mothers who had been taking norethynodrel (Conovid) (4.6% abnormal cells in test babies; 2.0% in controls).

Aneuploidy↗
PubMed1975

Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat.

The effect of methotrexate on the NADPH-dependent hepatic microsomal drug-metabolizing enzymes of the normal rat has been investigated. Pre-treatment of the animals with methotrexate for 3 successive days resulted in significant increases in the activities of biphenyl hydroxylase and ethylmorphine N-demethylase. The activity of these enzymes obtained from liver microsome preparations was also increased by methotrexate in vitro. The body weight, liver weight and the amount of both protein and DNA in each liver were significantly depressed by methotrexate treatment. All values, except the body weight, were increased to the control levels by additional treatment of the animals with phenobarbital. A likely explanation for the increase of enzyme activity by methotrexate has been discussed.

Animals↗
PubMed1975

Plasma and body lipids in patients with carcinoma of the breast.

Patients with breast carcinoma had elevated levels of plasma total lipids, phospholipids and cholesterol which were associated with increased amount of subcutaneous body fat as compared with the patients bearing non-breast carcinomas. The raised plasma concentrations of these parameters in the patients bearing breast carcinoma may be due to increased rate of lipid absorption as the fat-splitting enzymes, lipases, were also found to be increased in the patients.

Adipose Tissue↗
PubMed1975

Inhibition of mitosis and tritiated DNA precursor uptake in human leucocyte cultures by rat lymph node extract.

A water soluble extract was prepared from the lymph nodes of rats of different age groups. This extract, when added to human peripheral blood leucocyte cultures, inhibits DNA synthesis and mitosis when added in different concentrations for varying lengths of time in culture. Also, it was observed that the extract from old rats was not as effective as that from younger animals.

Age Factors↗