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Biomedical subjects

D C Turnell

Publications and source records attributed to D C Turnell.

22 records · Page 2Linked to original sources
PubMed1980

A rapid method for the determination of perhexiline in serum using gas-liquid chromatography.

A rapid method for the estimation of perhexiline in serum is presented. The procedure employs a single extraction, and no derivatisation is required. The procedure is linear over the range 0.4-4.0 mg/l, and the limit of detection is 0.09 mg/l. The within- and between-batch coefficients of variation at a concentration of 2.0 mg/l were 2.5 and 4.1%, respectively. Recoveries over the range 0.4-4.0 mg/l produced a mean of 104%. The method is free from interference by other common drugs used in the treatment of angina.

Adrenergic beta-Antagonists↗
PubMed1980

A 57Co-soap assay for plasma total non-esterified fatty acids compared with a gas-liquid chromatographic method.

We describe a relatively rapid radiochemical assay for determining plasma non-esterified fatty acids, by use of a Dole-type (J. Clin. Invest. 35: 150, 1956) extraction and formation of 57Co soaps. Results correlated well (r = 0.957) with those by gas-liquid chromatography. The between-batch CV for 1.12 mmol of non-esterified fatty acids per liter was 7%; the sensitivity is estimated to be 22 mumol/L.

Chromatography, Gas↗
PubMed1978

Blood intermediary metabolite and insulin concentrations after an overnight fast: reference ranges for adults, and interrelations.

Concentrations of several metabolites in deproteinized blood and plasma were determined in 100 subjects after an overnight fast, to establish reference ranges. Blood glycerol, nonesterified fatty acids, and ketone body concentrations and the 3-hydroxybutyrate/acetoacetate ratio increased with age while blood alanine concentrations delined. Serum insulin and blood alanine concentrations were also related to weight. No marked sex-related differences were found, although blood glycerol concentration was slightly higher in women. Distribution of all metabolite concentrations was positively skewed, except for glucose, but skewness could be corrected by logarithmic transformation. Skew was particularly marked for blood ketone body concentrations. Concentrations of all metabolites in plasma exceeded those in whole blood, but this was significant for only lactate and pyruvate when concentrations in plasma were compared with calculated concentrations in erythrocyte water.

Adult↗