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Biomedical subjects

D C Shreffler

Publications and source records attributed to D C Shreffler.

At least 145 records · Page 8Linked to original sources

Cytochrome oxidase deficiency in Wilson's disease: a suggested ceruloplasmin function.

The hypothesis is advanced that ceruloplasmin functions in enzymatic transfer of copper to copper-containing enzymes, such as cytochrome oxidase. To test this hypothesis, leucocytes from Wilson's disease patients, heterozygous carriers, and normal subjects were assayed for cytochrome-oxidase activity. The data reported here show markedly reduced levels of activity in Wilson's disease cases and moderate reductions in heterozygous individuals relative to normal controls. These observations and a close correlation between the level of cytochrome-oxidase activity in the leucocytes and ceruloplasmin in the serum tend to support the hypothesis.

Adolescent↗