The variation in levels of polychlorinated biphenyls (sigma PCBs), chlorobenzenes and chlorinated pesticides was studied in burbot (Lota lota) from eight remote locations along a northwesterly transect from northwestern Ontario to the Mackenzie River delta in Canada. Significant declines in concentrations of PCB congeners, DDT isomers (sigma DDT), lindane, dieldrin, and mirex in burbot liver were found with increasing north latitude. Mean sigma PCB concentrations ranged from 1,290 ng/g (lipid wt) at Lake 625, a remote lake in northwestern Ontario, to 301 ng/g in samples from the Mackenzie River at Arctic Red River, N.W.T. No significant differences in mean concentrations of toxaphene, alpha-HCH, tri- and tetrachlorobiphenyls were observed between southern and northern sampling sites. Toxaphene was the predominant organochlorine residue in northern fish samples averaging 1,400 ng/g (lipid wt) at the three most northerly sites and 1,723 ng/g at Lake 625. Airborne contamination was the only likely source of organochlorines for most of the locations surveyed. The results were consistent with the hypothesis that inputs of semi-volatile organochlorines to northern aquatic ecosystems decrease with increasing north latitude and distance from North American sources.

Animals↗

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Detection of triazine herbicides and their degradation products in tile-drain water from fields under intensive corn (maize) production.

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Agriculture↗

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Determination of terbutryn and its degradation products in water, sediments, aquatic plants, and fish.

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Animals↗

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A case-control study to investigate the association between indices of dust exposure and the development of radiologic pneumoconiosis.

A case-control study on employees at an iron ore surface mining plant was undertaken to determine which indices of occupational dust exposure related most closely to radiologic categories for pneumoconiosis. Forty cases, with radiographs compatible with the ILO Categories (1980) for simple pneumoconiosis, were matched for age, smoking habit, and date of entry into the workforce with 80 control subjects whose radiographs were read as normal. The six indices of dust exposure were cumulative and "peak" respirable dust, quartz, and iron oxide. Both iron oxide indices were not significant at the 5% level for either ILO Category 1 or Categories 2,3. The association between dust composition and ILO radiologic category for simple pneumoconiosis was consistent, with respirable quartz being the best differentiating index between the case and control groups.

Dust↗

PubMedDate not supplied

Pulmonary function in miners working in British collieries: epidemiological investigations by the National Coal Board.

Epidemiological investigations of ventilatory capacity in men working in British coal mines are reviewed. The results are related to radiological category of pneumoconiosis, respiratory symptoms, cigarette smoking and dust exposure. In summary it was found that dust exposure was associated with a fall in FEV1.0 but that there was no further fall assoicated with the presence of simple pneumoconiosis. Simple pneumoconiosis appeared to be evidence of the amount of previous dust exposure and suggested that this had been sufficient to cause a measurable fall in FEV1.0. The extent of the ventilatory impairment associated with simple pneumoconiosis was less than that due to age alone in most men. Cigarette smoking was found to be an important cause of ventilatory impairment.

Adult↗

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Gas chromatographic determination of picloram in fish.

A simple method for determining picloram in fish is described. The sample is homogenized with ethyl acetate, acidified with 1N HCl, and extracted twice more with ethyl acetate. Ethyl acetate fractions are pooled, derivatized with diazomethane, cleaned up by column chromatography, and analyzed by electron capture gas chromatography. Rainbow trout exposed to 14C-picloram were used to evaluate the efficiency of 2 methods of extraction and to provide data on the rate of uptake and the bioconcentration factor. The detection limit for this method is 5 ng/g, using a 4 g sample.

Animals↗

PubMedDate not supplied

Tentative explanatory variable of lung dust concentration in gold miners exposed to crystalline silica.

INTRODUCTION: The first objective of the study was to investigate the relationships between quantitative lung mineral dust burdens, dust exposure history, and pathological fibrosis grading in silicotic workers. The second objective was to evaluate the association between particle size parameters, concentration of retained silica particles and the severity of the silicosis. Sixty-seven paraffin-embedded lung tissue samples of silicotic patients were analyzed. The cases of silicosis included 39 non-lung cancer patients and 28 patients with lung cancer. All of the cases were gold miners in the Province of Ontario, Canada. MATERIAL AND METHODS: Particles, both angular and fibrous, were extracted from lung parenchyma by a bleach digestion method, mounted on copper microscopic grids by a carbon replica technique, and analyzed by transmission electron microscopy (TEM) and energy dispersive spectroscopy (EDS). Quartz concentration was also determined by X-ray diffraction (XRD) on a silver membrane filter after the extraction from the lung parenchyma. RESULTS: Total particles, silica, clay, and quartz also increase in concentration with increased age at death, although the trends are not statistically significant. Quartz concentration has a statistically significant correlation with the silicosis severity score (r = +0.45, p < 0.001), with the geometric mean concentration increasing from 2.24 micrograms/mg in the group having silicosis severity score less than 1 to 4.80 micrograms/mg in group with highest score. Quartz concentration is the only significant explanatory variable of the silicosis severity with a regression coefficient of +0.41 (p < 0.001). CONCLUSION: Among several dust exposure variables extracted from the work history of the miners, the calendar year of first exposure was the primary significant determinant of lung retained total particles, silica, and clay minerals, except for quartz. A statistically significant linear relationship between lung quartz concentration and silicosis severity in the gold miners was observed (p < 0.001). Among the several types of lung particles detected, quartz was the only significant determinant of the silicosis severity in the gold miners in this study and vice versa, although it explained only 20% of the variation in the severity. This study suggested no significant linear relationship between the duration of dust exposure and the lung burden of any particle types in the gold miners.

Aged↗