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Biomedical subjects

D C Morley

Publications and source records attributed to D C Morley.

At least 19 recordsLinked to original sources
PubMed1999

Growth monitoring: family participation: effective community development.

Growth monitoring was introduced into most developing countries in the 1970s with the aim of combating under nutrition in infancy and childhood. Ten years later analysis showed weight charts were not completed satisfactorily and not used in decision making. Although growth monitoring is now seldom mentioned in nutrition studies, the authors of this study are convinced of its value. With new technology using the direct recording scales (DRS), illiterate or semi-literate mothers are able to complete the growth curve on the weight chart and acquire understanding about the process and its significance for their infant. This study investigates the understanding of the growth curve by the rest of the family. The mother, their daughters and significantly, the grandmothers were shown to have comprehended the meaning of the growth curve. In families where mothers weighed their infant using the DRS, a smaller proportion were found to be suffering from periods of growth failure compared with families where the infant was weighed by community health workers with a dial scale. There are obvious gains if technologies are moved from the clinic into the family and the community. The weighing and charting of children by DRS may be a further step in the fight to overcome undernutrition in developing countries.

Adolescent↗
PubMed1989

Middle management: progress or demise?

Many Canadian health care facilities lack qualified, competent managers. Middle management positions are usually filled either by experienced technicians without managerial skills or training, or by business administration graduates who lack practical health care experience. Neither is satisfactory. This article stresses the need for better-trained administrators and for broader, more advanced training for technical personnel in order to prepare them for future managerial positions.

Canada↗
PubMed1989

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Canada↗
PubMed1986

Protrusio acetabuli prosthetica.

Protrusio acetabuli prosthetica is a form of hip replacement failure in which intrapelvic component migration occurs. Three degrees of the entity are defined as determined by (1) prosthetic migration medial to the ilioischial line and (2) integrity of the medial acetabular wall. Entities predisposing to protrusio acetabuli prosthetica include overreaming, multiple pelvic perforations, osteopenic bone states, infection, trauma, heredity or acquired bone deficiency states, overactivity, and hypertrophic membrane formation. Treatment of the condition is contingent upon (1) reestablishment of the radiographically determined anatomic position of the acetabulum and (2) construction of a medial prosthetic or biologic buttress. Recent techniques of biologic medial-wall formation utilize either allograft or autograft bone in one of three configurations--bulk, chipped or pulverized. In cases of severe intrapelvic hip protrusion, resection arthroplasty may be the only alternative.

Acetabulum↗
PubMed1984

Hemi-replacement arthroplasty of the proximal humerus. A case report.

A ten-year-old girl underwent excision of a chondrosarcoma of the right proximal humerus with subsequent insertion of a prosthesis. Failure of the device occurred six years after operation, requiring revision to an identical but shorter prosthesis. This device failed 1 1/2 years later and was replaced by a fibular graft inserted in the humeral medullary canal. The fibular graft was removed 18 months later, resulting in a flail right shoulder. The mode of failure in each instance was anterior and superior dislocation of the hemiarthroplasties. Currently, ten years after the initial procedure, the patient is tumor free with a shortened functional right upper extremity.

Bone Neoplasms↗
PubMed1983

Treatment of genu recurvatum by proximal tibial closing-wedge/anterior displacement osteotomy.

An operation is described for correction of the osseous form of genu recurvatum, which is secondary to premature closure of the anterior part of the proximal tibial physis with continued growth of the posterior part. At the Alfred I. duPont Institute 14 patients with 17 involved knees have been treated surgically for osseous genu recurvatum. All patients complained of cosmetic deformity, and nine of the 14 had pain. Etiologic factors included immobilization, trauma, and Osgood-Schlatter disease. The average age at surgery was 15 years six months, and the average follow-up period to date has been 20 months. Surgical procedures include the Irwin osteotomy (6 knees), the proximal opening-wedge osteotomy (2 knees), the distal closing-wedge osteotomy (1 knee), and the closing-wedge/anterior displacement osteotomy (8 knees). In all 17 of the knees in this series symptoms resolved following surgery, and 16 knees were stable at clinical examination. The closing-wedge/anterior displacement osteotomy has the advantages of rapid healing, good correction of the deformity, restoration of the depressed tibial tubercle, fewer complications, and resection of the remaining physis, which prevents recurrence.

Adolescent↗
PubMed1979

Factors influencing in vitro production of colony-stimulating factor by mononuclear leukocytes from humans.

The purpose of this study was to identify factors that influence the production of colony-stimulating factor by leukocytes of humans. The use of nonadherent light-density bone marrow cells is semisolid agar cultures to assay the concentrations of colony-stimulating factor in the supernatant of monocyte and mononuclear leukocyte cultures made it possible to distinguish between colony-stimulating factor, which stimulates colony-forming cells directly, and monocyte-dependent stimulating activity, which acts indirectly, by increasing the monocyte production of colony-stimulating factor. Colony-stimulating factor was not detectable in the cytosol of monocytes; that detected in culture must, therefore, have been newly synthesized. Synthesis was enhanced independently by heat-inactivated human serum and by semipurified serum fractions enriched with monocyte-dependent stimulating activity. The kinetics of the production of colony-stimulating factor in the presence and absence of monocyte-dependent stimulating activity indicated that the latter facilitated monocyte production of the former. Factors released from neutrophils were shown to reduce the production of colony-stimulating factor and thr proliferation of colony-forming cells and thus may provide a feedback control mechanism limiting the proliferation of neutrophils.

Colony-Stimulating Factors↗
PubMed1978

Effect of lithium on granulopoiesis in culture.

Lithium carbonate therapy is associated with polymorphonuclear leukocytosis. In vitro studies have shown that lithium ions stimulate formation of granulocytic colonies. In a study undertaken to determine how lithium acts, colony-forming cells uncontaminated by monocytes (which elaborate colony-stimulating factor [CSF] in vitro) were obtained by means of a two-step cell separation procedure. The effects of lithium on colony formation were then studied in (a) cultures stimulated by humoral CSF, (b) cultures in which monocytes were relied upon to synthesize CSF de novo and (c) unstimulated cultures. Lithium enhanced the action of CSF but did not stimulate colony formation in the absence of CSF. In monocyte-stimulated cultures, colony formation increased with lithium concentrations up to 1 mmol/L but this increase paralleled that in CSF-stimulated cultures and therefore was not due to increased CSF production by monocytes. At higher concentrations of lithium, colony formation decreased in the monocyte-stimulated cultures but increased in the CSF-stimulated cultures. A lithium concentration of 4 mmol/L gave the greatest enhancing effect on colony formation in CSF-stimulated cultures and a concentration greater than 1 mmol/L inhibited de novo synthesis of CSF by monocytes.

Cells, Cultured↗