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D C Lewis

Publications and source records attributed to D C Lewis.

79 records · Page 5Linked to original sources
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Polymorphonuclear neutrophil leucocytes in childhood Crohn's disease: a morphological study.

Light and electron microscopy was applied to surgical resections and endoscopic biopsies from the ileum and colon of 15 children with Crohn's disease in order to investigate the involvement of neutrophils in the disease process. Clear evidence was found of neutrophil infiltration of the lamina propria and epithelium, neutrophil migration into the gut lumen through epithelial breaks and intact epithelium, neutrophil phagocytosis of luminal and lamina propria bacteria, and the presence of intracellular neutrophils in enterocytes. Similar findings were seen in 5 of 6 children with ulcerative colitis and in a case of an E. coli colitis, but not in 8 controls. The observations demonstrate the involvement of neutrophils in Crohn's disease in childhood and suggest that the response is directed, in part, against luminal enterobacteria and enterocytes.

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Canine idiopathic thrombocytopenic purpura.

Canine idiopathic thrombocytopenic purpura (ITP) is a disease in which antibodies bound to the surface of platelets mediate premature platelet destruction by macrophages. ITP in dogs and chronic ITP in humans are analogous diseases. This article draws on information from the literature on ITP in dogs and in humans, and reviews the pathogenesis, diagnosis, and treatment of ITP in dogs.

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Successful treatment of regional enteritis in a dog.

Regional enteritis was diagnosed in an 11-year-old, spayed female German shepherd dog with a history of intermittent vomiting and anorexia. Segmental, transmural granulomatous enteritis involved the pylorus, jejunum, and ileum. The jejunal lesions were excised. The remaining lesions completely resolved subsequent to long-term prednisone and sulfasalazine therapy.

Animals↗
PubMedDate not supplied

Thrombocytopenia in dogs with anticoagulant rodenticide-induced hemorrhage: eight cases (1990-1995).

Thrombocytopenia was documented in eight of 11 dogs with anticoagulant rodenticide-induced hemorrhage. Thrombocytopenia was transient and generally mild-to-moderate, but it became marked (i.e., less than 30,000 platelets/microl) in two cases. Petechial hemorrhages were not noted in any case. There was no relationship between hematocrit and platelet count. Platelet count changes in response to treatment with fresh-frozen plasma and isotonic electrolyte solutions were variable. Anticoagulant rodenticide toxicity should be included as a differential diagnosis for dogs with hemorrhage accompanied by mild-to-moderate thrombocytopenia.

Animals↗