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Biomedical subjects

D C Keller

Publications and source records attributed to D C Keller.

At least 19 recordsLinked to original sources
PubMed2001

Segmental archwire mechanics.

Straight wire orthodontic methods cannot treat the significant compromises demonstrated in this article. These types of patients require a three-dimensional method of correction, which involves segmental orthodontics or a modified straight wire technique. This article will discuss how to use the information gathered from a three-dimensional evaluation of the stable mandibular/maxillary relationship using a diagnostic orthotic to treat to a three-dimensional balanced relationship. Structural and functional relationships exist between the final occlusal relationship and the function of the joints, muscles and upper quadrant that must be considered during orthodontic, orthopedic and restorative finalization procedures if long term permanence is to be obtained. This article demonstrates these relationships and provides a means to approximate the dentition to function in harmony with the associated structures.

Biomechanical Phenomena↗
PubMed2001

Diagnostic orthotics to establish the functional mandibular-maxillary relationship for orthodontic corrections.

Under optimal anatomic and physiologic circumstances, there exists a harmonious and functional balance between the occlusion, muscles of mastication and joint relationships referred to as a functional bite relationship. A diagnosis and treatment to the habitual bite relationship is provided if the function of the joints, muscles and associated structures is determined to be normal. If compromises of form or function are determined, a diagnostic orthotic is an essential tool to evaluate why the habitual bite position is not the best functional bite position and to also help determine a better functional relationship to avoid tissue and system compromise. The benefit of the diagnostic orthotic is the ability to establish an arbitrary reversible diagnostic relationship, evaluate the tissue and system response to this new association over time, and determine if the new treatment position is better for the patient than the habitual bite association.

Dental Occlusion↗
PubMed1996

Orthotics and orthodontics.

Many doctors think of orthotics or occlusal splints in connection with temporomandibular joint dysfunction patients and treatments. Few think of occlusal splints or intraoral orthotics in conjunction with orthodontics as diagnostic instruments. This article will demonstrate a close association between intraoral orthotics for diagnostic purposes to establish a functional mandibular-maxillary relationship before or during orthodontic treatment. Orthotics allow the practitioner to establish and maintain a harmony between the joint structures, the muscles and the dentition. Orthotics establish the stable orthopedic relationship prior to orthodontic intervention and thus, the end point of treatment established prior to irreversible corrections and a diagnosis of cause-effect relationships can be determined. Properly relating the mandible to the maxilla allows the opportunity to determine the arch developmental requirements necessary to maintain this functional relationship.

Humans↗
PubMed1993

Interleukin-11 inhibits adipogenesis and stimulates myelopoiesis in human long-term marrow cultures.

Interleukin-11 (IL-11) is a bone marrow (BM) stromal-derived growth factor that has been shown to stimulate murine myeloid and lymphoid cells both in vitro and in vivo and to inhibit adipogenesis in a murine fibroblast cell line. We have studied the effects of IL-11 on highly purified human BM stem and progenitor cells and on human long-term marrow cultures (LTMC). Adipocyte differentiation is an integral component of murine and human LTMC. IL-11 stimulates myeloid growth as a single cytokine when added to highly enriched CD34+, HLA-DR+ bone marrow cells. IL-11 stimulated no growth in the more primitive CD34+, HLA-DR- population even in the presence of additional cytokines. IL-11 addition to human LTMC resulted in the expansion of myeloid and mixed, but not erythroid, progenitor populations. IL-11 dramatically increased the adherent cell populations, including both stromal cells and macrophages. Treated cultures also showed marked inhibition of fat accumulation in the adherent cells due in part to a block in the differentiation of preadipocytes to adipocytes, as shown by RNA analysis using adipocyte-specific markers. These data show that IL-11 stimulates a more differentiated, although multipotential, progenitor cell in human BM and that LTMC provide a useful model for studying the effects of this cytokine in the context of the hematopoietic microenvironment.

Antigens, CD↗
PubMed1993

Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease.

Human cord blood (CB) contains large numbers of both committed and primitive hematopoietic progenitor cells and has been shown to have the capacity to reconstitute the lympho-hematopoietic system in transplant protocols. To investigate the potential usefulness of CB stem and progenitor cell populations to deliver new genetic material into the blood and immune systems, we have transduced these cells using retroviral technology and compared the efficiency of gene transfer into CB cells with normal adult human bone marrow cells using a variety of infection protocols. Using two retroviral vectors which differ significantly in both recombinant viral titers and vector design, low density CB or adult bone marrow (ABM) cells were infected, and committed progenitor and more primitive hematopoietic cells were analyzed for gene expression by G418 drug resistance (G418r) of neophosphotransferase and protein analysis for murine adenosine deaminase (mADA). Standard methylcellulose progenitor assays were used to quantitate transduction efficiency of committed progenitor cells, and the long term culture-initiating cell (LTC-IC) assay was used to quantitate transduction efficiency of more primitive cells. Our results indicate that CB cells were more efficiently transduced via retroviral-mediated gene transfer as compared with ABM-derived cells. In addition, stable expression of the introduced gene sequences, including the ADA cDNA, was demonstrated in the progeny of infected LTC-ICs after 5 wk in long-term marrow cultures. Expression of the introduced ADA cDNA was higher than the endogenous human ADA gene in the LTC-IC-derived colonies examined. These studies demonstrate that CB progenitor and stem cells can be efficiently infected using retroviral vectors and suggest that CB cells may provide a suitable target population in gene transfer protocols for some genetic diseases.

Adenosine Deaminase↗
PubMed1991

Eminence-posterior occlusal plane angle in patients with temporomandibular disorders.

The causes of temporomandibular disorder are not clearly understood. The controversy regarding the role of the features, either dental or skeletal, still exists after nearly a half century of debate. The present study demonstrates an interesting correlation, expressed as an angular value, between the posterior surface of the articular eminence and the posterior occlusal plane. The group with dysfunction had a mean value significantly lower (133 +/- 4) than the group without symptoms (144 +/- 5). In light of this data, it is suggested to interpret a small eminence-posterior occlusal plane as an anatomical predisposing pattern for dysfunction.

Adolescent↗
PubMed1989

Keller method of TMJ orthodontics.

This article explains a specific orthodontic method which has been designed to treat TMJ dysfunction patients. The desired mandibular/maxillary relationship is established and maintained throughout treatment. The resultant occlusion will then support a functional condyle-disc-fossa relationship. Cases are presented which illustrate the patented method and apparatus. Both patients have remained pain and dysfunction free for three years and five years respectfully.

Adolescent↗
PubMed1983

Septic arthritis caused by Kingella kingae.

A normal part of the oral flora, Kingella kingae has seldom been recognized as the cause of serious clinical infections. We report a case of documented septic arthritis caused by K. kingae in an otherwise healthy infant. We suggest that it may be more common than thought based on the general unfamiliarity with this organism and the fact that several dozen clinical isolates have been identified by reference laboratories.

Arthritis, Infectious↗