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Biomedical subjects

D C Heiner

Publications and source records attributed to D C Heiner.

112 records · Page 7Linked to original sources
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Delayed immunologic food reactions.

Delayed onset reactions to ingested foods may be difficult to recognize, especially if days or weeks elapse before symptoms appear. More than one immunologic mechanism may be involved and it is often difficult to assess the relative importance of each. Because immunologic responses occur in many healthy subjects who readily tolerate a specific food, little importance can be ascribed to a particular immunologic test unless it is shown that at least 95% of normals with similar exposure do not have such a response. Each food contains multiple antigens and allergic individuals differ considerably both in their immune responses and in the clinical manifestations they display. Because of this, the recognition and management of delayed food reactions is complex and requires an awareness of documented food-related disorders. It is a fruitful area for future research.

Animals↗
PubMedDate not supplied

IgG4 immunodeficiency.

IgG4 deficiency can be an isolated phenomenon, or it can occur in combination with deficiencies of IgG2, IgA, and/or IgG1 (in order of decreasing frequency). Isolated deficiency of IgG4 is associated with symptoms and signs which are similar to those associated with other IgG subclass deficiencies. The most common manifestation is an unusual frequency of pyogenic infections, most often of the respiratory tract. There is also an increased frequency of isolated serum IgG4 deficiency in subjects who have recurrent or chronic diarrhea, asthma, adverse reactions to foods, chronic candidiasis, pediatric AIDS, and autoimmune disorders. The mean and normal ranges of serum IgG4 in 400 subjects ages four months to 17 years are given. Diagnostic studies, unique features of IgG4, illustrative case reports and possible mechanisms are discussed.

Adolescent↗
PubMedDate not supplied

Prevalence of avocado allergy among atopic patients.

A 41-year-old woman with known food allergy to avocado was treated for anaphylaxis after eating a meal containing avocado. This prompted a study to determine the prevalence of avocado induced symptoms and skin reactivity in a group of atopic patients. One hundred consecutive atopic patients with allergic rhinitis undergoing skin testing before initiation of immunotherapy were also prick skin tested to avocado. Patients with symptoms upon avocado ingestion were also assessed for specific serum IgE antibodies to avocado. Of the 100 atopic patients not selected for avocado sensitivity, 21 had positive prick skin tests to avocado. Eight of the 21 avocado skin test positive patients reported that symptoms repeatedly followed the ingestion of avocado; two reported systemic reactions, but six noted oral symptoms only. Serum IgE antibodies to avocado were elevated in seven of the eight patients reporting symptoms after eating avocado. Seven of the eight patients also reported oral symptoms following cantaloupe ingestion. Four reported similar symptoms upon eating banana. Avocado-induced symptoms occurred in 8% of 100 consecutive atopic allergic rhinitis patients unselected for avocado reactivity. Oral, and less frequently systemic, allergy symptoms appear to be more common among the atopic population than previously appreciated.

Adult↗