Biomedical subjects
Publications and source records attributed to D C Govil.
The nails are commonly involved in cases of lichen planus of the skin and mucous membranes. However, in rare instances, the nails alone may be affected. A case of lichen planus limited to the nails in a 10-year-old boy is reported.
Renal functional status was evaluated in 122 patients with lepromatous leprosy. Renal functions were found to be markedly impaired in patients with erythema nodosum leprosum (ENL) in the active or quiescent phases. Although uncomplicated lepromatous leprosy patients did show significant renal impairment as compared to healthy controls, the degree of impairment was less than that of the reactive cases. Diminished endogenous creatinine clearance and proteinuria were the common abnormalities detected. Serum creatinine was significantly increased only in reactive cases. Blood urea was found to be marginally increased in a few patients although not to a statistically significant degree. Renal involvement did not bear any relation to the duration of illness or to the Bacteriological Index.
Twenty one patients of lepromatous leprosy were investigated for evidence of renal diseases. Histological lesions were observed in 76 percent cases. Sixty two percent of the cases showed a proliferative type of glomerulonephritis. Amyloidosis was present in 14 percent. The remaining 24 percent had either non-specific changes confined to renal tubules or were normal.
Sequential renal functions have been studied in eight patients of lepromatous leprosy during and after subsidence of erythema nodosum leprosum. The renal functions which were impaired during reaction were observed to improve during quiescent phase unless there were associated complications like amyloidosis. The possible mechanisms for altered renal functions during reactive phase of the disease have been discussed.
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