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Biomedical subjects

D C Dunn

Publications and source records attributed to D C Dunn.

At least 37 records · Page 2Linked to original sources
PubMed1990

Characterization of inflammatory cells in a patient with chronic periaortitis.

During repair of an inflammatory abdominal aortic aneurysm, fresh samples of the aneurysm wall were obtained. Histology confirmed the diagnosis of chronic periaortitis,- advanced atherosclerosis with medial attenuation, and periaortic inflammation. Monoclonal antibodies were used to identify the cells of the inflammatory infiltrate. The majority of the adventitial lymphocytes were B cells. No B cells were present in the atheroma. The majority of mature plasma cells contained IgG with a few plasma cells containing IgM. T cells, predominantly T helper cells, were found in the atheroma and adventitia. Positive DR staining was shown by the majority of lymphocytes, by macrophage-like cells in germinal centers of lymphoid follicles in the adventitia, by some vascular endothelial cells, and by some smooth muscle cells. The implications of these findings are discussed.

Antibodies, Monoclonal↗
PubMed1989

Benign cystic teratoma of the ovary rupturing into the rectum: a rare problem.

Benign cystic teratoma of the ovary is a common neoplasm which only rarely presents as a result of ovarian rupture. Rupture into the rectum has been described infrequently. We describe a case of rupture of an ovarian cystic teratoma which presented as a change in bowel habit, due to faeces filling the cyst and compressing the rectum.

Aged↗
PubMed1988

Audit of a surgical firm by microcomputer: five years' experience.

From 1982 to 1986 inclusive work of one surgical firm was audited with a microcomputer. Data were recorded on 4336 patients having 3355 operations, who were under the care of one consultant in a general surgical unit; fifty items of information were recorded on each patient, allowing a wide range of analyses to be performed--for example, the number of admissions and operations, grades of operation, diagnostic grouping, complications, and complication rates associated with individual surgeons. Data collected for the audit provided a valuable baseline for the unit, defining aspects of practice that could be reviewed and improved. During the audit the overall rate of complications as a percentage of admissions fell significantly from 13% to 9% and the rate of postoperative complications decreased significantly from 16% in 1982 to 11% in 1986. The incidence of chest and wound infections also decreased significantly. The system was improved by using the data to produce discharge summaries as well as audit; the microcomputer thus became an integral part of the office work of the unit.

Computers↗
PubMed1986

Combined computer generated discharge documents and surgical audit.

A computerised audit system using a commercially available database program and a word processing program was devised to produce discharge documents close to the time of discharge. The data were available for audit of the surgical unit's work. It was found that secretarial time was more efficiently used and general practitioners received more information about their patients earlier than before.

Computers↗
PubMed1986

Detection of bovine herpesvirus-specific nucleic acids by in situ hybridization with biotinylated DNA probes.

Biotin-labeled DNA probes for bovine herpesvirus type 1 (BHV-1) were used to detect viral nucleic acids in infected cell cultures and clinical specimens by in situ hybridization. Hybridization signal was detected 2 hours after inoculation in the cytoplasm of infected cells, presumably representing input virus. Hybridization was first detected in the nucleus at 4 hours after inoculation; by 10 hours after inoculation, hybridization signal was detected in both nucleus and cytoplasm of almost 50% of the cells. By 15 hours after inoculation, 95% of the cells were positive. Treatment of specimens with ribonuclease or deoxyribonuclease before hybridization allowed clear differentiation of virus-specified DNA and RNA within infected cells. The BHV-1 nucleic acid sequences were detected in nasal epithelial cells obtained from inoculated calves. Since in situ hybridization provides a rapid technique for the detection of BHV-1-specified nucleic acid sequences, it should facilitate studies on the replication, pathogenesis, and diagnosis of BHV-1 infections.

Animals↗
PubMed1981

Highly selective vagotomy and pyloric dilatation for duodenal ulcer with stenosis.

This paper presents the results obtained in 15 patients with duodenal ulcer and stenosis who were treated more than 3 years ago by highly selective vagotomy (HSV) and dilatation of the stenosis without a gastric drainage procedure. Patients were taking solid food 3--6 days postoperatively and were discharged after 7--14 days. There have been no recurrent stenoses. Fourteen of the 15 patients were Visick grade 1 or 2 at their last visit. One patient has a recurrent ulcer, but no restenosis. Barium meals performed on 6 patients with severe stenosis preoperatively showed satisfactory gastric emptying 1--3 years postoperatively. HSV and pyloric dilatation seems to be a safe and effective procedure for the treatment of pyloric stenosis due to chronic duodenal ulceration.

Dilatation↗
PubMed1980

An evaluation of highly selective vagotomy in the treatment of chronic duodenal ulcer.

A randomized trial of highly selective vagotomy against truncal vagotomy and gastroenterostomy has been performed. Forty patients have been analyzed. All operations were performed by one surgeon with previous experience with highly selective vagotomy. Comparisons during the operation indicated that highly selective vagotomy took longer to perform and had a greater associated blood loss. Patients with highly selective vagotomy recovered more rapidly after operation as the duration of ileus postoperatively was shorter. Both operations effectively reduced basal and insulin-stimulated peak acid outputs. At the time of follow-up study, at six weeks and six months postoperatively, patients with highly selective vagotomy had significantly better over-all Visick gradings and had better gradings for the symptom of diarrhea. The differences between the two groups gradually diminished after a year, although diarrhea remained significantly worse in patients who had truncal vagotomy. There were no recurrences of ulcer in either group up to one year postoperatively. Highly selective vagotomy has significant advantages over truncal vagotomy and gastroenterostomy in the immediately postoperative period and up to one year after operation. Only a marked increase in bad results from highly selective vagotomy after a year could justify the continued use of truncal vagotomy and gastroenterostomy.

Adult↗
PubMed1979

Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers.

34 patients treated with cyclosporin A received 36 cadaveric organ allografts (32 kidneys, 2 pancreases, and 2 livers), 26 kidneys are still supporting life, 3 after more than a year; the pancreases and livers are also functioning. 20 patients are not receiving steroids, and 15 of these have not had any additional immunosuppressive agents. In these patients infectious complications have not been severe, but a gastroduodenal lymphoma has developed in 1 patient. 6 patients were given 'Cytimum' (a cyclophosphamide derivative) and steroids in addition to cyclosporin A: 5 of these died of infections and 1 also had a lymphoma. 11 patients received additional steroids: 1 of these died from septicaemia and lymphoma. Nephrotoxicity can be avoided by perioperative hydration and forced diuresis. Cyclosporin A is effective on its own and is a very potent immunosuppressive drug. Additional immunosuppressive agents may lead to severe complications.

Adult↗
PubMed1979

Prolonged kidney allograft survival with promethazine.

The effects of promethazine hydrochloride have been investigated in a rabbit kidney allograft model. The drug was ineffective on its own, but if added to a protocol that induced partial suppression of rejection in 50% of recipients, its effect was dramatic. Allograft survival was prolonged from a control mean of 10.3 days to a mean of 26.3 days. One animal survived 2 1/2 months, and no other drug than promethazine was given after day 6. Promethazine and 6-methylprednisolone alone also prolonged allograft survival, but the results were significantly better if the recipient had been exposed to donor blood before grafting. The results suggest that promethazine is a useful adjuvant immunosuppressive drug. It could be beneficial in man.

Adjuvants, Immunologic↗