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Biomedical subjects

D C Doll

Publications and source records attributed to D C Doll.

At least 73 records · Page 4Linked to original sources
PubMed1985

Neoplasia and the erythron.

Neoplasms may affect the erythroid system in a variety of ways. By far the most common abnormality associated with neoplastic disorders is anemia. It is important to recognize that there are multiple causes of anemia associated with neoplasms, because therapy of the anemia varies according to the causative mechanism. Less commonly, the paraneoplastic syndrome of erythrocytosis may occur in some patients with neoplasia. More subtle abnormalities of the erythrocytes associated with malignant disease include modification of the RBC membrane, changes in erythrocyte enzymes, and abnormalities in hemoglobin production. Clinical awareness of the multiple effects of neoplasms on the erythron will lead to better patient management and may also improve our understanding of erythropoiesis.

Anemia↗
PubMed1982

Chemotherapy of pulmonary blastoma: a case report and review of the literature.

Pulmonary blastoma is a rare lung tumor of uncertain histogenesis. Although surgery may be curative therapy for localized lesions, recurrent tumor has been resistant to various treatment modalities. We report a case of metastatic pulmonary blastoma that had a partial remission with combination chemotherapy. Suggestions are made for the treatment of localized and metastatic pulmonary blastoma.

Adolescent↗
PubMed1982

Surface morphology of platelets in spur-cell anemia.

Spur-cell anemia is characterized by the presence of an abnormally shaped erythrocyte, the acanthocyte. Platelets from two patients with spur-cell anemia were studied by scanning electron microscopy to determine whether there were any abnormalities of platelet shape. In both cases, irregularly distributed bulbous-like projections were observed on the platelet surface membrane. These observations suggest that platelets from patients with spur-cell anemia have an abnormal surface morphology.

Anemia, Hemolytic↗
PubMed1982

Spur cell anemia.

The clinical and laboratory findings in eight patients with spur cell anemia are presented and compared with other cases gathered from the literature. Although there is no specific clinical or laboratory abnormality, the condition can be recognized by a constellation of findings. The majority of patients have a long history of ethanol abuse with clinical and laboratory manifestations of hepatocellular dysfunction. All patients have anemia, a reticulocyte count usually greater than 5%, and indirect hyperbilirubinemia. The sine qua non for the diagnosis of spur cell anemia is an increased percentage (usually greater than 20%) of acanthocytes on a peripheral smear. The prognosis of spur cell anemia is poor, the majority of patients dying within a year. From our study, spur cell anemia appears to be more prevalent than is generally reported.

Acanthocytes↗
PubMed1982

Squamous cell carcinoma of the pancreas associated with hypercalcemia.

Squamous cell cancer of the pancreas is a rare variant of pancreatic ductal cell carcinoma. This tumor has not been reported to be associated with hypercalcemia in the absence of primary hyperparathyroidism or bone metastases. We present a patient with pancreatic squamous cell carcinoma who presented with intractable hypercalcemia, had normal parathormone levels, and was found at autopsy to have normal parathyroid glands and no evidence of bony metastases. A review of squamous cell carcinoma of the pancreas and pancreatic neoplasms associated with hypercalcemia is presented.

Bone Neoplasms↗
PubMed1978

Lymphoma of the prostate presenting as benign prostatic hypertrophy.

A case of lymphocytic lymphoma involving the prostate is reported. Lymphomatous infiltration of the prostate had been mentioned infrequently in the literature, so that the incidence, prognosis, and treatment are not well known. Lymphomatous or leukemic infiltrate should be considered as a causative agent of prostatism, particularly in patients with hematologic abnormalities where chemotherapy may relieve the symptoms.

Aged↗
PubMed1977

Sign of Leser-Trélat.

We report a case of squamous cell carcinoma of the lung associated with the sudden appearance of seborrheic keratosis and acquired ichthyosis. We conclude that the sign of Leser-Trélat is a rare cutaneous manifestation of internal malignant disease.

Age Factors↗
PubMed1977

Unusual presentations of multiple myeloma.

Multiple myeloma has many unusual manifestations, which may obscure the true cause and delay proper treatment. Physicians in all specialties should be alert to this possibility, since myeloma may be at the root of such diverse disorders as carpal tunnel syndrome, peripheral neuropathy, solitary lytic bone lesions, hypercalcemia, and hyperviscosity syndrome.

Adult↗
PubMed1976

Klinefelter's syndrome and extragenital seminoma.

An extragenital metastatic seminoma in a patient with Klinefelter's syndrome is described. The increased incidence of many types of malignancies in patients with this chromosomal abnormality and the increased susceptibility of XXY cells to transformation by oncogenic SV-40 virus are discussed. A relationship is suggested circumstantially by these observations.

Adult↗