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Biomedical subjects

D C Chung

Publications and source records attributed to D C Chung.

67 records · Page 4Linked to original sources
PubMed1984

Continuous in-vivo monitoring of arterial oxygen tension in a patient treated with bleomycin.

Patients receiving bleomycin therapy may develop pulmonary fibrosis. The risk of fibrosis is increased by the administration of general anaesthesia and fatal cases with pulmonary lesions resembling those of "oxygen toxicity" have been reported. The causes are not entirely clear but the enriched inspired oxygen given intraoperatively or postoperatively has been identified as an etiological factor. Optimal intraoperative management thus requires the administration of the lowest inspired oxygen fraction (FIO2) compatible with adequate oxygenation. To achieve this aim safely, continuous in vivo monitoring of arterial oxygen tension would be preferable to intermittent sampling of blood gases. We report the successful management of a patient undergoing thoracotomy following bleomycin therapy using an intravascular PO2 sensor to monitor arterial oxygen tension continuously. The uses and limitations of the PO2 sensor are discussed.

Adult↗
PubMed1982

Respiratory effects of nitrous during enflurane anesthesia in humans.

The authors measured resting ventilation, the ventilatory response to added CO2, the VD/VT ratio, the rate of carbon dioxide output, and arterial PCO2 in four healthy volunteers, awake and anesthetized with, in order (I) enflurane 0.4 MAC with nitrous oxide 70 per cent, (II) enflurane 1.1 MAC with nitrous oxide 70 per cent, and (III) enflurane 1.1 MAC alone. Enflurane 1.1 MAC reduced ventilation and the response to added CO2 markedly, increased the VD/VT radio, reduced rate of CO2 output, and elevated values of PaCO2 from 41 +/- 1 to 65 +/- 3 mmHg (mean +/- SEM). Enflurane 1.1 MAC with nitrous oxide 70 per cent had similar effects. Enflurane 1.1 MAC with nitrous oxide 70 per cent had similar effects. Enflurane 0.4 MAC with nitrous oxide 70 per cent caused much smaller changes in each measured respiratory variable, increasing PaCO2 values to only 49 +/- 1 mmHg. The results indicate that enflurane 1.1 MAC alone is too potent a depressant of alveolar ventilation to permit spontaneous breathing, but that the "equi-anesthetic" enflurane 0.4 MAC with nitrous oxide 70 per cent may not be. The magnitude of the beneficial respiratory effects of substituting nitrous oxide for an equivalent amount of vapor is substantially greater with enflurane than with either halothane or isoflurane.

Adult↗
PubMed1982

In-vivo comparison of the adsorption capacity of "superactive charcoal" and fructose with activated charcoal and fructose.

This study was undertaken to assess the in-vivo capacity of two activated charcoal products to adsorb aspirin after its ingestion by seven healthy volunteers. The two products, Norit-A and Super-Sorb, were combined with fructose solution and administered after the subjects ingested 975 mg of aspirin. Urinary excretion of salicylates was measured during both charcoal administration phases and after ingestion of aspirin alone in all subjects. Results showed statistically significant differences in salicylate excretion between all phases. Super-Sorb ("superactive charcoal") adsorbed almost twice (1.7) as much as aspirin as the regular activated charcoal, Norit-A. Super-Sorb therefore has a greater in-vivo adsorption capacity for aspirin and should be a more effective antidote in poisonings with this drug.

Adjuvants, Pharmaceutic↗
PubMed1980

Hypoxic gas mixtures delivered by anaesthetic machines equipped with a downstream oxygen flowmeter.

The oxygen concentration of fresh gas mixtures delivered to a Bain circuit by a Boyle's anaesthetic machine equipped with leaking oxygen flowmeters was measured at the common gas outlet during free flow and during controlled ventilation of a model lung. The results demonstrate that, despite satisfactory oxygen and nitrous oxide rotameter settings, such a machine can deliver hypoxic fresh gas mixtures irrespective of whether the leaking flowmeter is mounted downstream or upstream. This selective loss of oxygen increases with the size of the leak and increases with the back pressure on the flowmeter assembly during controlled ventilation. A downstream position of the oxygen flowmeter should not be regarded as foolproof. Continuous monitoring of the oxygen concentration of fresh gas mixtures with an in-line oxygen analyzer is recommended.

Anesthesiology↗
PubMed1977

Effect of thiopentone on myocardial function.

In a canine preparation designed to separate myocardial from peripheral cardiovascular effects of the drug. It was found that thiopentone produced minimal depression of the heart. Only in much greater concentrations was significant depression found. It is concluded that the cardiovascular effects of thiopentone i.v. are not a direct effect on the heart.

Animals↗
PubMed1976

Anaphylaxis to thiopentone: a case report.

A case of anaphylaxis to thiopentone is reported and its immediate treatment with epinephrine is emphasized. Other reported cases of allergic reaction to thiopentone and to muscle relaxants are reviewed. There are no reliable diagnostic tests for allergy to these agents.

Anaphylaxis↗
PubMedDate not supplied

Gabapentin for the treatment and prophylaxis of cluster headache.

BACKGROUND AND OBJECTIVES: Cluster headache is an uncommon debilitating condition for which effective management remains a challenge. We describe the use of gabapentin in the treatment and prophylaxis of cluster headache in a patient who was refractory to other treatments. CASE REPORT: A 38-year-old man had a history of intermittent right-side headaches for 24 years, diagnosed as cluster headache. He received only partial relief from a range of conventional treatments. A trial with gabapentin 300 mg twice daily was tried and found to be effective in treatment and prophylaxis of his headaches. CONCLUSION: Gabapentin was effective in the treatment of a patient with cluster headache. Further investigation of gabapentin compared with conventional treatments and placebo is warranted.

Acetates↗