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Biomedical subjects

D C Burke

Publications and source records attributed to D C Burke.

At least 73 records · Page 4Linked to original sources
PubMed1975

Stability of the cervical spine after conservative treatment.

175 patients with cervical spine and spinal cord injuries were admitted to the Spinal Injuries Unit, Austin Hospital, in the five-year period from the 1 July 1968, to the 30 June 1973. Only 4-2 per cent of the patients required delayed spinal fusion for instability after a conservative treatment regime.

Adult↗
PubMed1975

Interferon induction by viruses and polynucleotides: a differential effect of comptothecin.

The plant alkaloid comptothecin inhibits interferon production induced by Newcastle disease virus (NDV) or ultraviolet-irradiated NDV in chick and human cells, and by Sindbis virus in chick cells. It has no effect on interferon production induced by poly (rI).poly(rC) in chick and human cells. No effect of comptothecin could be detected on the multiplication of NDV, and it is concluded that the inhibition reflects a difference between interferon induction by viruses and by polynucleotides.

Animals↗
PubMed1975

Processing of alphavirus-specific proteins in infected cells.

The RNA of the alphaviruses contains the genetic information for both the non-structural and the structural polypeptides. The former are contained in the initial two-thirds of the sequence (from the 5'-terminus) and are read directly from the virus particle RNA, but whether post-translational cleavage is involved or not is not known. The genes for the structural polypeptides are in the final one-third of the genome, and are probably not read directly but are transcribed selectively to produce a sub-genomic messenger RNA with only one initiation site. Translation produces the structural pooypeptides and post-translation cleavage does occur. However, the rate at which cleavage occurs is variable--cleavage to release the core polypeptide occurs while the nascent polypeptide is still attached to the ribosome, while cleavage to form two of the virus envelope glycoproteins occurs as the virus buds from the cell. The cleavage mechanism which leads to release of the core polypeptide also takes place in vitro and may be catalysed by the structural polypeptide itself.

Arboviruses↗