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Biomedical subjects

D Byrne

Publications and source records attributed to D Byrne.

121 records · Page 7Linked to original sources
PubMedDate not supplied

Antihypertensive effect of carteolol in thiazide-treated hypertensive subjects.

The antihypertensive effect of carteolol, a new potent nonselective beta-adrenergic antagonist, was investigated in a double-blind, parallel study of 35 patients with mild-to-moderate, essential hypertension whose blood pressures were not adequately controlled with a diuretic. Patients were randomly assigned to receive placebo, carteolol 5 mg, or carteolol 20 mg once a day in addition to hydrochlorothiazide 50 mg for six weeks. Thirty-four patients completed the study: 11 patients received placebo (group 1), 12 patients received carteolol 5 mg (group 2), and 11 patients received carteolol 20 mg (group 3). After six weeks of treatment, the two groups that received carteolol had significant reductions in systolic (SBP) and diastolic (DBP) blood pressure from baseline in both the supine and standing positions. In group 2, mean SBP decreases for supine and standing positions were 11 +/- 2.1 and 11 +/- 1.9 mm Hg, respectively (P less than .01) and 8 +/- 1.2 and 9 +/- 1.3 mm Hg, respectively, for DBP (P less than .01); whereas in group 3, values were 8 +/- 2.8 and 12 +/- 3.0 mm Hg for SBP, in 5 +/- 1.9 and 9 +/- 3.1 mm Hg, respectively, for DBP (P less than .01). The hypotensive effect was associated with slight but significant decreases in heart rate (P less than .01 in group 2 and P less than .05 in group 3). Reductions in SBP and DBP with the 20-mg dose were not significantly different from those with the 5-mg dose.2+ moderate hypertension.

Adult↗
PubMedDate not supplied

Sound field audiometry: recommended stimuli and procedures.

Comprehensive recommendations are presented for conducting sound field audiometry with frequency specific stimuli. These recommendations are primarily based on a series of investigations by the authors. The rationale for each recommendation is presented, together with a brief overview of the supporting research. The preferred stimuli are frequency modulation tones, triangularly or sinusoidally modulated at a rate of about 20 Hz, or suitably generated narrow bands of noise. The optimal bandwidths of the stimuli, expressed in percentages of the center frequency, vary with frequency. Stimuli suitable for most purposes have bandwidths ranging from about 30% at 0.25 kHz to about 10% at 4 kHz. Stimuli having narrower or broader bandwidths are desirable for some special purposes. The test room should be as nonreverberant as possible and the subject should be seated on an adjustable height chair with headrest. The control microphone method of calibration is preferred but a method is also presented for carrying out the traditional precalibration procedure. The SPL of the complex stimulus should be taken as the peak deflections on a sound level meter set to "RMS-FAST." A conversion table is presented which allows thresholds obtained in the sound field to be expressed as dB HTL. With the materials and methods described here it is possible to achieve the same reliability for sound field testing as for audiometry under earphones.

Acoustic Stimulation↗
PubMedDate not supplied

Parvovirus as a differential diagnosis of hydrops fetalis in the first trimester.

We report a case of fetal parvovirus B19 infection which appears to have resulted in hydrops in the first trimester. An ultrasound scan performed at the booking visit of a woman in the first trimester showed generalised oedema. Karyotyping to exclude a fetal abnormality was normal. Maternal radioimmunoassay serological investigations showed parvovirus B19 IgG and IgM. Post-mortem analysis revealed intranuclear inclusion bodies typical of parvovirus in the erythroid cells in the liver and in the myocardium.

Adult↗
PubMedDate not supplied

Comment on shapiro: "comparison of three hearing aid prescription procedures".

This letter disputes the conclusion of an article which compared 3 hearing aid prescription procedures. The data which allegedly suggest that one procedure, based on Most Comfortable Loudness level measurements, is superior to the other procedures, based on Hearing Threshold Level measurements, merely illustrate the variability of most comfortable loudness level measurements. No evidence is produced to show which, if any, of the procedures is most accurate. It is also pointed out that the article does not indicate some of the most important differences in the procedures.

Acoustics↗
PubMedDate not supplied

Caring for the dying: nurses' experiences in hospice care.

This article reports on a phenomenological study of nurses' experiences of caring for dying patients in a Western Australian hospice. Data obtained from indepth interviews with nine experienced hospice nurses were analysed using Colaizzi's method. The five major themes that emerged from the data indicated that: nurses were transformed by the experience of caring for dying patients; the hospice context influenced caring; caring was embodied in nurse-patient interactions; caring extended to patients' families and nurses developed strategies to cope with their experience. The implications of the findings are that awareness of the effects of their caring activities on patients, their families and themselves is essential to nurses' maintenance of self and to their ability to enable patients to make choices. Suggestions are made for future research of the importance of caring contexts in both comforting patients and in preparing them for death.

Adaptation, Psychological↗