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Biomedical subjects

D Buskila

Publications and source records attributed to D Buskila.

At least 181 records · Page 10Linked to original sources
PubMed1987

Cardiovascular manifestations of ankylosing spondylitis.

In a retrospective study, 40 patients with ankylosing spondylitis were assessed for extraspinal manifestations. Cardiovascular complications were found in 17 patients (42.5%): 5 (12.5%) had aortic insufficiency, 3 (7.5%) had atrioventricular block and 5 (12.5%) had bundle branch block. Wolff-Parkinson-White syndrome was diagnosed in one case and short PR syndrome in another. Cardiovascular complications were more common in patients with longer disease duration. Ischemic heart disease was found in 17.5% of the cases and pulmonary fibrosis in 15%. Peripheral arthritis was found in 42.5% and its prevalence did not differ in patients with or without cardiac involvement.

Adolescent↗
PubMed1987

Polyagglutination in hospitalized patients: a prospective study.

A hospital population at high risk for red cell polyagglutination was studied prospectively in search for cryptantigen exposure. The patients included in this study suffered from: malignancies, sepsis, direct antiglobulin test (DAT) negative anemias and various combinations of these three. 238 patients were examined, and 18 of these (7.6%) were found to have exposed cryptantigens on their erythrocytes. This is an unexpectedly high percentage. Our findings suggest that cryptantigen exposure on the red cells is a more common phenomenon than previously described, especially when looked for in a carefully chosen population. The red cells of these patients are potentially polyagglutinable, and screening with lectins will ensure their pretransfusion identification and evaluation.

Adult↗
PubMed1987

Low serum antimycobacterial glycolipid antibody titers in the sera of patients with systemic lupus erythematosus associated with central nervous system involvement.

Antibodies which bind to glycolipids derived from Mycobacterium tuberculosis were sought in the sera of patients with systemic lupus erythematosus (SLE), with and without neurological disease, patients with active tuberculosis and normal controls. A significantly lower activity against the mycobacterial glycolipids was detected in the sera of patients with SLE with neurological involvement compared to other patients with SLE or controls. We suggest that low antibody levels against mycobacterial glycolipids may be useful in the diagnosis of patients with SLE in whom involvement of the central nervous system is suspected.

Antibodies, Bacterial↗
PubMed1987

ELISA measurement of antibody titer to purified protein derivative and mycobacteria-derived phosphoglycolipids: tool for diagnosing active pulmonary tuberculosis.

There is a continuous search for a rapid, efficient and reliable serodiagnostic technique for active tuberculosis (TB). Using ELISA (enzyme-linked immunosorbent essay) we have determined antibodies reactive to purified protein derivative (PPD) and two phosphoglycolipids extracted from Mycobacterium bovis cell wall, phosphatidyl inositol dimannoside (PID) and phosphatidyl inositol pentamannoside (PIP). Twenty-one patients of Ethiopian origin with active pulmonary TB and 20 healthy control subjects vaccinated with BCG in infancy were evaluated. A significantly higher level of immunoglobins reactive with the antigens was found among the patients with active pulmonary TB. The mean +/- SD of the OD units (x 10(3)) recorded in the sera of TB patients compared with control subjects were as follows: using PPD 250 +/- 210 vs. 120 +/- 150 (P less than 0.025); with PID 1,150 +/- 470 vs. 750 +/- 150 (P less than 0.01); and with PIP 1,170 +/- 500 vs. 780 +/- 160 (P less than 0.025). Accordingly, the sensitivity and specificity levels were: with PPD 81 and 75%, with PID 82 and 80% and with PIP 73 and 70%, respectively. Much more accuracy can be obtained by calculating the results of reactivity toward the combined free antigen assays. It is suggested that ELISA using mycobacterial derived antigens might be useful in the diagnosis and screening of active pulmonary TB in large populations, due to its rapidity and simplicity.

Antibodies, Bacterial↗
PubMed1987

Quinidine-induced lupus erythematosus-like syndrome: three case reports and a review of the literature.

Three patients with an LE-like syndrome secondary to quinidine are described. Twenty-two similar cases are reviewed. The clinical picture is characterized mainly by polyarthritis, pleuritis, fever and dermatitis. The common laboratory findings are positive antinuclear antibodies, absence of anti-DNA antibodies, thrombocytopenia, leukopenia and abnormal liver function tests. This LE-like syndrome may appear within days or up to several years after the start of quinidine treatment and disappears completely a few weeks after discontinuation of the drug.

Aged↗
PubMed1987

Limited joint mobility and other rheumatological manifestations in diabetic patients.

Limited joint mobility was diagnosed in 42.9% of Type I and 37.3% of Type II diabetic patients. Abnormally thick skin was detected in 31.4% of Type I and 33.7% of Type II diabetic patients. Skin abnormalities were observed mainly in patients with L.J.M. There was a high prevalence of hand flexor tendon abnormalities (18.6%). Decreased range of shoulders and hips and flexor tendon abnormalities were significantly more common in patients with LJM. No significant association was found between LJM and grip strength, joint complaints, family history of rheumatic diseases, hypoglycemic attacks, cardiovascular diseases and autonomic neuropathy.

Adolescent↗
PubMed1986

[Polyagglutination].

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Blood Group Antigens↗