Biomedical subjects

D Burnel

Publications and source records attributed to D Burnel.

39 records · Page 3Linked to original sources

PubMedDate not supplied

Element variations in pregnant and nonpregnant female rats orally intoxicated by aluminum lactate.

Pregnant or nonpregnant female rats were orally intoxicated by aluminum lactate (400 mg Al/kg/d) from d 0-19 of gestation to determine the treatment's influence on element variations in the females and their fetuses. The aluminum levels of plasma, liver, spleen, and kidneys were significantly higher in treated pregnant rats than non-pregnant female rats. Differences of P, Ca, Cu, Zn, or Mg levels were observed among the four groups of female rats in the tissues and plasma. The aluminum content of the 20-d-old fetuses did not significantly differ between the treated and control groups. On the contrary, calcium and magnesium levels in the whole fetuses from treated or nontreated dams are significantly different.

Administration, Oral↗

PubMedDate not supplied

Effects of postnatal aluminum exposure on choline acetyltransferase activity and learning abilities in the rat.

Young rats were treated by gastric intubation with aluminum lactate (0, 100, and 200 mg Al/kg/day) from postnatal days 5 to 14 to determine the treatment's influence on brain choline acetyltransferase activity and learning abilities. The results indicated that aluminum concentrations in the cerebral areas increased in parallel to plasma aluminum at the dose of 200 mg. In the same case, choline acetyltransferase activity was reduced. At postnatal days 50 and 100, the treated rats did not show alterations in their learning abilities in the 2 tests which are based on different motivations (avoidance of an aversive light or alimentary motivation) and different ways of achievement (pressing on a lever or running in a maze). A low reduction in the general activity, particularly in the radial maze test, was only observed in rats treated with 200 mg Al/kg/day.

Animals↗

PubMedDate not supplied

[Toxicity and pharmacokinetics of zirconium oxychloride in mice and rats].

The experimental toxicity of zirconium compounds is examined in the Mouse (acute toxicity) and in the Rat (short time toxicity). The absorption, the distribution and the elimination of zirconium are evaluated by zirconium cation assay in some biological fluids and tissues. After a single oral dose, zirconium oxyd is not toxic, zirconium oxychlorure slightly toxic and zirconium chlorure moderately toxic. At certain concentrations, cerebral and pulmonary disorders are observed, particularly with zirconium chlorure. In considering molar toxicity, the studied zirconium compounds are more toxic than certain aluminium salts mentioned in the literature. The zirconium oxychlorure doesn't influence the growth curve after iterative administrations (0.23 g zirconium/kg/day). Only a weak fraction of administered zirconium is absorbed and is electively fixed in the ovaries, in a lesser degree in the lung and the bone. In the ovary the zirconium induces vascular variation (hypervascularization) which appear one month after the end of the treatment. The absorbed zirconium is eliminated by the urinary tract. The fecal elimination can be essentially explained by an important quantity of non absorbed zirconium.

Animals↗