Biomedical subjects
Publications and source records attributed to D Brinkley.
A prospective randomized clinical trial of treatment with vincristine, cyclophosphamide, methotrexate and 5-fluorouracil after conventional curative treatment for stage II breast cancer is described. The results at 2 years are recorded together with details of toxicity. Future plans are discussed briefly.
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Long term follow-up suggests 30-40 per cent of "early" cases are "cured" by treatment. The proportion cured is probably related to the biological characteristics of the tumour rather than to the primary treatment. Careful staging is the best prognostic indicator available at present. Efforts should be made to learn more about the behaviour of tumours and to continue long term follow up.
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The results of 5-day cyclical combined chemotherapy for advanced breast cancer were compared in two trials with the less demanding 1-day and 2-day regimens. At all stages, except at 3 months, 5-day treatment was significantly more successful in providing regression and remission of tumours than the 1-day regimen. However, although the differences are not statistically significant, data from the second trial indicated that the 2-day regimen tended to be more effective than the 5-day regimen. The lower 95% confidence limit for the success of the 2-day treatment was 56.2% at 3 months.
Results are presented of a long-term follow-up of patients with breast cancer seen in the Cambridge area from 1947 to 1950. After 21 years the survival curve of the breast-cancer patients runs parallel to the expected survival curve of a similar normal population. This suggests that 18% of all the breast-cancer patients may be regarded as cured of their disease in the sense defined by Easson and Russell. An analysis of the causes of death in the study group after 20 years' follow-up shows an excess of deaths from breast cancer. The number is 16 times more than would be expected in the normal population, although the overall death-rates in the two groups are the same. This questions the concept of cure.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.