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Biomedical subjects

D Brighouse

Publications and source records attributed to D Brighouse.

At least 19 recordsLinked to original sources
PubMed1997

An unusual complication following combined spinal-epidural anaesthesia for caesarean section.

The combined spinal-epidural technique is widely used in obstetric anaesthetic practice. Epidural catheter migration through a dural hole is a theoretical but rarely described complication. We report a case of acute and life-threatening respiratory depression following administration of diamorphine through an epidural catheter after a single space combined spinal-epidural technique for caesarean section. We believe this complication occurred as a result of catheter migration through a dural hole into the subdural space and rupture of the thin arachnoid layer causing massive subarachnoid blockade.

Journal Article↗
PubMed1995

Spinal anaesthesia for transurethral surgery: comparison of 2% lignocaine with hyperbaric 0.5% bupivacaine.

We have compared 2% lignocaine 3.5 ml with 0.5% hyperbaric bupivacaine 3 ml in a randomized, double-blind study in 30 patients undergoing subarachnoid anaesthesia for transurethral surgery. A sensory level of T10 was produced more quickly (P = 0.0001) and maximum height reached sooner (P = 0.0002) with lignocaine, although there was a greater reduction in systolic arterial pressure (P = 0.03) and a trend towards slower heart rates (P = 0.056). Return of full sensory and motor function occurred earlier with lignocaine (P = 0.00005 and P = 0.02).

Aged↗
PubMed1994

Hyperventilation-induced unconsciousness during labour.

We report the development of unconsciousness caused by hyperventilation in an otherwise healthy woman in labour. Extradural analgesia resulted in restoration of full consciousness and normal respiratory state. The pathophysiology of hyperventilation and aspects of respiratory physiology in pregnancy are discussed.

Adult↗
PubMed1992

Anaesthesia for caesarean section in a patient with Ehlers-Danlos syndrome type IV.

We report the successful use of combined spinal and extradural anaesthesia for elective Caesarean section in a primigravid patient with Ehlers-Danlos type IV (EDS IV). EDS IV is a rare disorder with a high pregnancy-related mortality. Previous reports have not addressed the question of anaesthesia for delivery. It is not possible to be didactic about anaesthetic technique for such patients. The relative risks of general and regional anaesthesia must be discussed fully, and the risks weighed against the wishes of the woman and her partner.

Adult↗
PubMed1990

Unusual complications of the treatment of chronic spinal arachnoiditis.

The causes, diagnostic features, and therapy of chronic spinal arachnoiditis are reviewed. Two unexpected results from attempted epidural injections (one of lignocaine and clonidine, and one of lignocaine, clonidine, and morphine) in patients with this condition are described. The anatomical abnormalities of the epidural and subarachnoid spaces in such patients and the consequent unpredictable and potentially dangerous results that may follow drug injection into these spaces are discussed.

Aged↗