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Biomedical subjects

D Brewer

Publications and source records attributed to D Brewer.

51 records · Page 3Linked to original sources
PubMed1973

Successful treatment of Pseudomonas cepacia endocarditis with trimethoprim-sulfamethoxazole.

A patient with a history of alcoholism and drug abuse who developed Pseudomonas cepacia endocarditis is described. The organism was found to be resistant in vitro to all common antimicrobial agents except chloramphenicol and trimethoprim-sulfamethoxazole. Treatment failed with penicillin and streptomycin and later with chloramphenicol. Orally administered trimethoprim-sulfamethoxazole, however, resulted in sterilization of the patient's blood and aortic valve which was resected 27 days after the start of therapy. A 6-week course of therapy was completed and, to date (6 months after treatment), there has been no recurrence.

Administration, Oral↗
PubMedDate not supplied

Evaluation of the effectiveness of adolescent drug abuse treatment, assessment of risks for relapse, and promising approaches for relapse prevention.

A review of controlled evaluations of adolescent and other drug abuse treatment programs concludes that some treatment is better than no treatment, that few comparisons of treatment method have consistently demonstrated the superiority of one method over another, that posttreatment relapse rates are high, and that more controlled studies of adolescent treatment which allow evaluation of the elements of treatment are needed. In the absence of the clear superiority of specific treatment techniques, it is suggested that examination of factors related to relapse can provide an empirical base for identifying effective treatment approaches. Pretreatment, during-treatment, and posttreatment factors related to relapse are reviewed from existing studies of adolescent treatment. Program components are suggested which have been associated with or hold promise for reducing factors associated with higher relapse rates and increasing factors associated with lower relapse rates.

Adolescent↗
PubMedDate not supplied

The effect of drug sampling policies on residents' prescribing.

BACKGROUND AND OBJECTIVES: Many clinical educators feel that the availability of drug samples has an influence on the prescribing habits of residents. Therefore, many programs limit the availability of samples. This study compares the prescriptions written in three family practice residency programs with different policies on availability of drug samples. METHODS: We used a prospective observational design to compare three programs of similar size and curriculum but which differed in sampling policies. One program had no limitation of samples, one program limited samples to specifically approved drugs, and one program did not permit drug samples in the clinic. Carbonless duplicate prescriptions were collected and collated over the first 5 months of 1996, and prescribing of nonsteroidal anti-inflammatory drugs (NSAIDs) was monitored. RESULTS: There was a greater percentage of generic prescriptions and use of preferred NSAIDs but no decrease in the "cost per prescription" in the programs that limited or eliminated samples when compared to the program with an "open" sample policy. There was no statistically significant difference between the program with no samples and the program that permitted only approved drugs. CONCLUSIONS: The elimination or control of available drug samples is associated with differences in the prescriptions written by family practice residents, but this effect is fairly small.

Anti-Bacterial Agents↗