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Biomedical subjects

D Borochovitz

Publications and source records attributed to D Borochovitz.

29 records · Page 2Linked to original sources
PubMed1981

The extracapsular spread of tumors in cervical node metastasis.

Extracapsular spread (ECS) of lymph node metastases is believed to be an indicator of poor prognosis. In general, it has been thought that ECS was limited to large "fixed" nodes. To test the validity of the assumption that nodes less than 3 cm in diameter do not have ECS, the specimens from 177 radical neck dissections were reviewed retrospectively with regard to ECS. Sixty-five percent of the nodes that were 2.9 cm or less in diameter were found to demonstrate ECS. We found no substantial difference in the number of patients who had no histologic disease in their necks when compared with a second group of patients who had metastasis confined to the lymph node. The patients whose lesions had ECS had statistically significantly reduced numbers of survivors. Other factors, eg, tumor differentiation and the number of malignant nodes, had no prognostic importance. The impact of ECS on staging, the reporting of retrospective reviews, and therapy are discussed.

Carcinoma, Squamous Cell↗
PubMed1981

Osteomyelitis of a bone graft of the mandible with Acanthamoeba castellanii infection.

An ameloblastoma of the right side of the mandible was resected in a 32 year old prediabetic female. An iliac crest autograft became infected and a sequestrum was removed seven weeks later. Pathologic examination of this tissue demonstrated a mixed infection, including Acanthamoeba castellanii. This is the first recorded instance of invasion of bone by a free living ameba.

Adult↗
PubMed1981

Fatal Epstein-Barr virus infection in a 63-year-old man. An autopsy report.

A 63-year-old man with acute, heterophil-negative Epstein-Barr (EBV) viral infection displayed neurologic impairment that progressed to coma and death. Fever, pharyngitis, and lymphadenopathy were notably absent. There was no lymphocytosis, and multiple peripheral smears revealed few atypical lymphocytes. Results of specific EBV serology were diagnostic of acute infection. At the time of autopsy, there was massive intravascular and perivascular infiltration of all organs by lymphocytes and atypical mononuclear cells. There was depletion of the paracortical T-lymphocyte areas of lymph nodes. The atypical mononuclear cells did not contain intracytoplasmic immunoglobulin, as shown by the immunoperoxidase technique, nor did they take up esterase stains, but their electron-microscopic features were characteristic of lymphoid cells. These morphologic findings suggest a T-cell defect, with unrestricted proliferation of B lymphocytes. The lack of characteristic clinical and hematologic features in this case underscores the value of specific EBV serology in the diagnosis of acute heterophil-negative EBV infection.

Acute Disease↗
PubMed1981

Cutaneous malakoplakia.

A case of cutaneous malakoplakia is reported. The patient is a 53-year-old white woman on immunosuppressive therapy 6 years after renal transplantation for end-stage nephrosclerosis. She developed yellow-pink papular lesions in her natal cleft which, on histopathologic examination, showed typical features of malakoplakia, namely, a diffuse dermal infiltrate of histiocytes (von Hansemann cells) which contained calcified Michaelis-Gutmann bodies with a concentric ring appearance. Gram-negative bacteria were also identified in some of the histiocytes. The Michaelis-Gutmann bodies stained positively with the PAS-diastase, mucicarmine, and Grocott stains and thus resembled fungal spores from which they must be differentiated. Electron microscopy showed that the Michaelis-Gutmann bodies developed within phagolysosomes of the histiocytes. Malakoplakia appears to be caused by an acquired defect in the intracellular digestion of phagocytized bacteria.

Escherichia coli↗
PubMed1980

Histologic changes in previously irradiated thyroid glands.

Thyroid tissue from 90 patients with a history of therapeutic irradiation to the head and neck in childhood and adolescence was examined microscopically. In addition to the well-known observation that these individuals have an increased incidence of primary thyroid carcinoma, it was also demonstrated that they have an increased incidence of benign histologic changes. These changes represent a spectrum from nonspecific hyperplastic lesions to benign neoplasia and thyroiditis.

Adenoma↗
PubMed1979

Gastrointestinal mucosa and primary gastrointestinal lymphoma.

The primary gastrointestinal lymphomas in Shiraz, Iran, and Richmond, Virginia, USA were compared. Upper duodenojejunal lymphoma is always associated with atrophy of the surrounding nonlymphomatous mucosa, plasma cell infiltration and formation of lymph follicles. This is frequently linked to repeated gastroenteritis leading to mucosal atrophy, mutation of plasma cell precursors and secretion of alpha-heavy-chain. Gastrointestinal lymphoma in the USA and other industrialized countries is found in the stomach, where it is accompanied by superficial perifoveolar plasma cell gastritis of the surrounding mucosa, or in the performed lymphoid tissue of the ileocolon, surrounded usually by normal mucosa. A hypothesis for the pathogenesis of the different types of primary gastrointestinal lymphoma, considering the geographic distribution, and mucosal and immunologic antecedents, is presented.

Adult↗
PubMed1977

Chemotherapy of malignant mesothelioma.

Twenty-three patients with malignant mesothelioma are described as to mode of presentation, symptoms, method of diagnosis and histology, Beginning in 1972, 10 patients were treated with drug combination including Adriamycin, Dacarbazine (DTIC), Cytoxan, and vincristine. Median survival of these patients was 9.5 months. Twelve patients who were treated with other modes of therapy had a median survival of about 4.75 months. One patient died after 22 days in the hospital, for whom a diagnosis was made at autopsy. While historical retrospective controls involving 13 patients are of limited value in assessing the usefulness of a new treatment, the authors feel that combination chemotherapy in 10 patients has shown enough activity to warrant further study. In addition, wide local resection, where possible, probably increases survival.

Adult↗
PubMed1977

Sclerosing hemangioma of the lung: an endothelial or epithelial neoplasm?

The ultrastructural features of a sclerosing hemangioma of the lung in a 34 year old woman are described. The basic cellular response is thought to be endothelial and not epithelial. These conclusions are based on the finding of Weibel-Palade bodies within the tumor cells in addition to other characteristics generally associated with endothelial cells.

Adult↗