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Biomedical subjects

D Boonzaier

Publications and source records attributed to D Boonzaier.

3 recordsLinked to original sources

Determining locations of intracerebral lesions for proton radiotherapy.

Using an external view of the head, the ability to direct a proton radiotherapy beam at an intracerebral lesion is described, using a biostereometric (BSM) technique. The positions of markers, recognizable on computed tomography (CT) or magnetic resonance (MR) images, at known locations on the skin of a patient's head are related to the site of the lesion seen on the images. The markers' positions are determined by a BSM device, incorporating six video cameras coupled to a computer. A transformation from a coordinate system, defined by the CT or MR images, to another coordinate system, that of the BSM device, allows the proton beam to be directed towards the lesion. Markers used in this work were solid steel spheres for CT and plastic spheres containing oil for MR images.

Biomarkers

Initial experimental experience with a "replaceable" cardiac valve prosthesis.

An easily "replaceable" cardiac valve prosthesis has been designed. It consists of two parts: (1) a sewing ring incorporating a circlip and (2) a functioning valve (either mechanical or tissue). The circlip is encased in a sewing ring, which is sutured into the natural valve annulus, and grips the functional part of the prosthesis, thereby preventing dislodgment. A simple instrument has been designed to open the circlip a few millimeters to allow easy removal or insertion of the functional element. This sewing ring/circlip with the functional element of a Björk-Shiley prosthesis was used in 10 baboons undergoing mitral valve replacement. Removal and replacement of the functional element was carried out at a second operation between 1 and 12 weeks later. There were no operative deaths. Baboons were electively killed one day to twelve months after the second operation. There were no complications related to the prosthesis; cardiac catheterization showed normal hemodynamics before and after the second operative procedure.

Animals