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Biomedical subjects

D Bontoux

Publications and source records attributed to D Bontoux.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Double half-body radiotherapy in myeloma].

Seven patients with advanced multiple myeloma, failing to respond (1 case) or relapsing (6 cases) after conventional chemotherapy with melphalan, cyclophosphamide and prednisone, were treated with double half-body irradiation. Two patients died before the irradiation could be completed. The five patients who received the total dose of irradiation obtained a reduction in their tumour mass of between 40 and 80%. There was an incomplete and inconstant effect on pain and functional status. The haematological toxicity was marked and one patient died after 7 months from marrow failure. One of the four remaining patients relapsed after 3 months and the other three are still in remission after 6, 8 and 10 months. In the present state of knowledge, double half-body irradiation should be considered to be a form of salvage treatment for myelomas not responding to chemotherapy.

Female↗
PubMed1984

Double hemibody irradiation in chemotherapy-resistant multiple myeloma.

Seven patients with high-mass multiple myeloma resistant to chemotherapy were treated by double hemibody irradiation (DHI). The total-body myeloma cell mass decreased from 38% to 80% for the five patients who received a complete treatment. Pain and performance status were improved. Hematological toxicity was severe, and one patient died after 3 months from marrow aplasia. Survival from 3 to greater than 19 months was obtained after the completion of DHI. According to our experiment, DHI can be considered as a treatment of last resort for resistant multiple myeloma.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Femoral neuralgia and diabetes. Method of clinical approach].

A retrospective study allowed us to work out an original method for an essentially clinical approach of the correlation between femoral neuropathy and diabetes mellitus. Nine parameters were chosen for this purpose and a score was developed. From this score, three categories were defined: in each, the existence and etiological probability of diabetes mellitus are discussed. This clinical approach is a simple means of establishing more accurate guidelines for complementary investigations.

Diabetes Complications↗
PubMed1983

[Vertebral osteonecrosis. Apropos of 4 cases with slow spinal cord compression in 1 case].

The authors report on four cases of aseptic osteonecrosis of the vertebral body in adults (VON). Among these, one patient, in whom histological data were available, presented with a slow spinal cord compression syndrome (SSCCS). This complication is uncommon since only one other similar case has been reported so far (4). VON thus remains an underestimated etiology of SSCCS by non-tumoral compression fracture of the vertebral body. Diagnosis is based on the roentgenograms which evidence osteocondensation with "gaseous dissection" of the vertebral body, the latter being considered as pathognomonic of this disease. The etiopathogeny is still unknown. Treatment is purely symptomatic and the course has always been favorable.

Aged↗
PubMed1983

[Plasmocyte dyscrasia with polyneuropathy, polyendocrinopathy and polyadenopathy].

A 72 years old, male complains difficulty in walking, a peripheral neuropathy of four limbs is found. Clinical examination shows a peripheral lymphadenopathy predominating in left inguinal nodes. A malignant IgA k plasmocytoma is seen on lymph node biopsy. There is no pathological plasmocytosis on bone trephine biopsy. Bone radiographies are normal. Immunoelectrophoreses finds a monoclonal IgA lambda protein of little abundance without lowering of other immunoglobulins. Insufficiency of adenohypophysis clinically suspected, is confirmed by static and dynamic tests as well as anomaly of glucose tolerance. Biopsies of skin, muscle and nerve show neither plasma cell infiltrate nor amyloid deposit. Evolution is stabilized during 12 months by an hematosarcoma type treatment which must be stopped because of bad hematologic tolerance. This interruption is followed by a fast severe evolution that leads to death in few weeks. This case as comparable with those reported by japanese authors in Far East and of which rare cases have been reported in non japanese people. It seems that the association of a non myelomatous plasma cell dyscrasia of uncertain malignancy with peripheral neuropathy, endocrinic, cutaneous and various visceral signs must be individualized. It could be considered as a particular paraneoplastic syndrome more especially as in many case the cure of the plasma cell proliferation has been followed by disparition of visceral signs.

Aged↗
PubMed1983

[Study of a sub-population of T-lymphocytes with the HLA-DR molecule in rheumatoid polyarthritis].

The sub-population of T-lymphocytes which express the DR antigen was studied in 48 patients with rheumatoid arthritis and in 42 controls. The sub-population of T-lymphocytes which express DR was found to be larger in the patients with rheumatoid arthritis. This increase is even more marked in cases of rheumatoid arthritis with high erythrocyte sedimentation rates and with a high level of immune complexes.

Adult↗
PubMed1983

[Secreting parathyroid carcinoma. Apropos of a case].

Parathyroid carcinoma is rare and hits diagnosis often difficult. A case is reported, remarkable by the age of the patient (17 years), and the main peculiarities of the disease are reviewed: frequency of complete bone syndrome, palpable tumour of the neck, calcemia more than 140 mg/l, occurrence of recurrent palsy; relapsing course, death being dependent on hypercalcemia rather than metastasis; median survival time about five years, non influenced by chemotherapy. Ultrastructural study, previously realized in about thirty cases, is specially evaluated: it seems able to concur on anatomopathologic diagnosis, when assertion of malignancy is difficult.

Adenoma↗
PubMed1983

[Arterial hypertension with secondary hyperaldosteronism, reversible by nifedipine, in systemic scleroderma].

A case of severe hypertension with secondary hyperaldosteronism developing in a 71 year old woman affected by "Crest" syndrome is reported. The patient was treated by nifedipine, which led to the correction of blood pressure, plasma renin activity and serum aldosterone. The role of renal arteries vasospasm and renin-angiotension system in the genesis of scleroderma is discussed.

Aged↗
PubMed1982

[Bone metastasis of breast cancer. Apropos of a series of 50 cases].

Among fifty patients with bone metastases from breast cancer who were hospitalized between 1971 and 1980, 19 were given intermittent chemotherapy including both hormone-therapy (drostanolon propionate and tamoxifen) and a combination of cyclophosphamide, methotrexate, 5 FU, doxorubicin and vincristine (CMFDV). Comparison of these patients with two other groups given either miscellaneous chemotherapy programs (19 cases) or no chemotherapy (12 cases) exhibited the value of the standardized protocol, especially concerning median survival which exceeded three years (versus one year with the two other methods). Cobalt-therapy, chemotherapy and hormone-therapy in bone metastases from breast cancer are reviewed.

Antineoplastic Agents↗