Biomedical subjects
Publications and source records attributed to D Birnbaum.
The Capiox 54, Interpulse and TMO oxygenators were compared under clinical conditions. None of the devices is ideal, however all are reliable in regard to gas exchange and laboratory data. Evacuation of air (CO2) seems a problem in Capiox, high pressure amplitudes are suspicious for creation of extreme shearing in Interpulse and TMO may reveal low (dead) flow areas within the blood path's.
The expression of the erbB2 and p53 proteins was examined by immunohistochemistry in a series of 81 cases of primary breast carcinomas treated with an adjuvant chemotherapy with a median follow-up of 5 years. Expression of erbB2 was present in 19 cases (23%), 50% of them with more than 70% of positive tumoral cells. Expression of p53 was present in 32 cases (39%), 50% of them with more than 30% of positive tumoral cells; coexpression of erbB2 and p53 was observed in 11 cases (13.5%). Disease-free and overall survival of the patients were correlated with the number of positive lymph nodes (p = 0.08, p = 0.015). No significant trend was observed in response to adjuvant chemotherapy in correlation with erbB2 or p53 expression or both, whatever the level of expression.