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Biomedical subjects

D Birkhed

Publications and source records attributed to D Birkhed.

At least 109 records · Page 6Linked to original sources
PubMed1991

Caries-preventive effect on primary and permanent teeth and cost-effectiveness of an NaF tablet preschool program.

The aim was to assess restorative care, approximal caries, and cost-effectiveness in children at the ages of 8 and 17 yr in relation to NaF tablet intake between 1/2 and 7 yr of age. Based on interview data, 304 subjects (born 1967 in Lund, Sweden) were divided into five groups with different periods of consumption and one group with no intake. A statistically significant difference was found in fs at 8 yr (P less than 0.001) and in FS at 17 yr (P less than 0.01) between children who had taken the tablets regularly from the first year of life to age 5-7 yr (fs = 1.9; FS = 3.8) and the non-consumers (fs = 5.2; FS = 5.9). In the other four tablet groups, both the fs and the FS values tended to decrease with increasing duration of intake. The prevalence of approximal caries also tended to decrease, as regards both dfs and DFS, increasing duration of tablet consumption, with an statistically significant difference (P less than 0.001) in primary teeth between children with the longest intake (dfs = 1.4) and non-consumers (dfs = 4.9). The cost-effectiveness ratio was approximately 1:1 for both dentitions. Most of the effect was obtained in the primary dentition.

Adolescent↗
PubMed1991

Effects of chemically modified starches in suspensions and lozenges on pH of human dental plaque.

The aim was to evaluate chemically modified starches (CMS) from a cariologic point of view as alternatives to gum arabic in sugar-free lozenges. Two commercial CMS, Purity Gum 40 and Capsul, were selected due to their comparatively low availability to alpha-amylase in vitro. Both gelatinized CMS suspensions and lozenges were tested in vivo by measuring plaque pH. The results showed that suspensions of Purity Gum 40 or Capsul were less available to alpha-amylase in vitro than the soluble starch reference. However, the initial phase of amylolysis was comparatively rapid also with CMS. In spite of the slower rate of hydrolysis, suspensions of the two CMS reduced pH of dental plaque in vivo to the same extent as soluble starch, but somewhat less compared with glucose. Lozenges with Purity Gum 40 also lowered plaque pH, although less than when administered as a precooked suspension. The most prominent pH drop was found with a lozenge containing Purity Gum 40-sucrose-glucose, while tablets with gum arabic-maltitol and pectin-gelatine-Lycasin somewhat increased the pH values. To conclude, it is not recommended to exchange gum arabic for CMS in sugar-free lozenges, since the cariogenic properties of the products are negatively affected.

Dental Plaque↗
PubMed1991

Oral sugar clearance in elderly people with prosthodontic reconstructions.

The aim was to study oral sugar clearance in elderly individuals, around 70 yr of age, with various types of prosthodontic reconstructions. Salivary glucose concentration was measured under the tongue after chewing a glucose tablet in four groups of individuals with: 1) complete dentures (CD) (n = 19), 2) removable partial dentures (RPD) (n = 22), 3) fixed partial dentures (FPD) (n = 24), and 4) no dentures (controls) (n = 23). Salivary glucose clearance was also studied after a mouthrinse with 10% glucose in 18 of the 19 individuals with CD and in 13 of the 22 with RPD both with and without the dentures. Saliva samples for glucose analysis were taken, in this part of the experiment, at two separate locations: under the tongue and in the labial vestibule near the mandibular right first molar. After the tablet intake, the group with CD showed the highest initial salivary glucose concentration, the longest oral sugar clearance time and the largest area under the curve, followed by the group with RPD. FPD did not seem to influence the oral sugar clearance. After the glucose rinse, higher values for the various clearance variables were obtained in the vestibule than under the tongue and, to some extent, when the experiments were carried out with than without the dentures. Thus, the results from this study indicate that removable dentures, especially CD, contribute to less effective oral sugar clearance in elderly people and that the oral clearance seems to be more dependent on the site than on the presence or absence of removable dentures in the oral cavity.

Aged↗
PubMed1991

Caries-preventive effect of dentifrices containing various types and concentrations of fluorides and sugar alcohols.

The caries-inhibiting effect of unsupervised daily use of four different toothpastes was compared in a 3-year clinical and microbiological study: (1) 0.8% sodium monofluorophosphate (MFP) with 3% xylitol and 6% sorbitol; (2) 0.03% sodium fluoride with 3% xylitol and 6% sorbitol; (3) 0.8% MFP with 9% sorbitol, and (4) 0.03% sodium fluoride with 9% sorbitol. In all 284 children, 12-13 years old at baseline, took part in the study. After 3 years, no statistically significant differences were found between the different toothpaste groups concerning either development of initial or gross caries lesions or number of mutans streptococci and lactobacilli in saliva. However, children with no detectable approximal caries at baseline, who used the MFP toothpaste with the xylitol-sorbitol mixture, showed a lower (p less than 0.05) caries increment as compared with children who used the MFP toothpaste with sorbitol alone.

Adolescent↗
PubMed1991

Oral sugar clearance in children compared with adults.

The aim of the present investigation was to study oral sugar clearance of various types of foodstuffs in children of different ages in comparison with adults. Thirty children and 20 adults were selected constituting five groups, each containing 10 individuals: 3-, 7-, 15-years-olds and adults, all with normal salivary secretion rate, and adults with low salivary secretion rate (dry mouth patients). Oral sugar clearance was studied using three glucose-containing products: solution, tablet and biscuit. Repeated saliva samples were collected every other minute, between 1 and 11 min after the intake, with a convenient method suitable for very young children. For that purpose, a small circular paper disc, absorbing approximately 20 microliters of saliva, was placed under the tongue for 10 s. The glucose concentration of the samples was then analyzed enzymatically. The results showed that, in children, the oral sugar clearance became faster with increasing age. The adults and the 15-year-olds had similar patterns of clearance, while the dry mouth patients had the slowest oral clearance of all groups. The 3- and 7-year-olds showed the greatest variation in oral clearance between the various foodstuffs; the solution had faster clearance than both the biscuit and the tablet. The main conclusion from this study is that young children (3- and 7-year-olds) have both slower salivary sugar clearance and larger variation in clearance among various foodstuffs than older children and adults.

Adolescent↗
PubMed1991

Effect of partial substitution of invert sugar for sucrose in combination with Duraphat treatment on caries development in preschool children: the Malmö Study.

The aim was to study the effect of substitution of invert sugar for sucrose, in combination with fluoride varnish (Duraphat) treatment twice a year, on caries development in preschool children. One hundred and eighty-seven 4-years-olds were divided randomly into four sugar groups: (1) sucrose (S), (2) sucrose-Duraphat (SD), (3) invert sugar (I), and (4) invert sugar-Duraphat (ID). All families were asked to buy beverages, biscuits, breakfast cereals, marmalade, ice cream, jam, ketchup, sweets and table sugar, totally 32 different food items, sweetened with invert sugar or sucrose. The substitution was, thus, restricted to a number of sugar-rich between-meal products. The study was carried out double-blind for 2 years. The children of those parents who did not want to participate in the sugar groups were divided randomly into one of the following two groups: (5) Duraphat (D), and control (C). Because of lack of cooperation, only 114 of the 187 children (61%) were considered to have completed the study. The mean caries increment, including initial lesions, was 3.86 dmfs in the combined groups S and SD (n = 63) and 3.10 dmfs in the combined groups I and ID (n = 51) during the 2 years (p = 0.34). The corresponding values for the 2nd year only were 1.84 and 0.67 dmfs, respectively (p = 0.09). The mean caries increment was 2.86 dmfs in group D (n = 113) and 4.10 dmfs (p = 0.08) in group C (n = 93). If initial caries lesions were excluded from the index, the difference between groups D and C was significant (p = 0.008).(ABSTRACT TRUNCATED AT 250 WORDS)

Cariogenic Agents↗
PubMed1991

Factors associated with active and inactive root caries in patients with periodontal disease.

The aim of this study was to analyze a number of microbial, salivary, and dietary factors in patients with clinically active and inactive root caries. 147 patients, aged 30-78 years, referred for specialist treatment of periodontal disease, were randomly selected. 645 decayed and 539 filled root surfaces were found. Out of the carious lesions, 372 (58%) were recorded as clinically active and 273 (42%) as inactive. 30 patients showed no lesions (group 1), 46 had only fillings or inactive lesions (group 2), and 35 showed 1-2 (group 3) and 36 greater than or equal to 3 active lesions (group 4). The lactobacillus count differed significantly between all groups, except group 1 vs. 2, and the mutans streptococcus count between groups 1 vs. 4 and 2 vs. 3 and 4. Group 4 differed in plaque score from the other groups, and the salivary buffer effect differed between the inactive groups 1 and 2 and the active group 4. By stepwise multiple regression analysis, it was shown that lactobacillus count, plaque index, salivary buffer effect, dietary habit index, and number of exposed root surfaces contributed significantly to the coefficient of determination.

Adult↗
PubMed1991

Effect of dentifrices containing either xylitol and glycerol or sorbitol on mutans streptococci in saliva.

In 76 adults, randomly distributed between two groups, a comparison was made of the effect on the level of mutans streptococci in saliva between two dentifrices containing: (1) xylitol (9.9%) and glycerol (20%) or (2) sorbitol (28%) as humectants. After the use of the dentifrices twice daily for 3 months, the levels of mutans streptococci had not changed significantly in the sorbitol-treated group, whereas a significant reduction (p less than 0.0005) was found in subjects using the xylitol/glycerol dentifrice. The difference between the two dentifrice groups based on the changes observed during the 3-month period was also significant (p less than 0.02).

Adult↗
PubMed1991

Effect of a buffering sugar-free lozenge on intraoral pH and electrochemical action.

Two double-blind crossover studies were performed to test a sugar-free lozenge containing bicarbonate and phosphate buffers (Profylin). The studies were performed in groups of 20 and 13 individuals. In Study I active buffering or placebo lozenge (not buffered) was given, and the pH of plaque and saliva was measured after 2, 5, 10, 20, and 30 min. In study II the lozenges were given 10 min after a sucrose rinse, and both the pH and the potential and polarization of amalgam restorations that made contact in the oral cavity were measured. In study I both lozenges increased the pH of plaque and saliva, but the values after sucking on the active lozenge were significantly higher than after placebo. In study II a pH recovery of plaque and saliva after the sucrose rinse was recorded for both types of lozenge, but it was most pronounced for the active, buffering lozenge. A statistically significant difference was, however, found only 5 min after sucking on the lozenge. No influence on the current magnitude was observed. The results thus indicate that the buffering sugar-free lozenge raises the pH of plaque and saliva and accelerates the pH recovery after a sucrose rinse but seems to have no influence on the galvanic current magnitude of amalgam restorations in contact.

Buffers↗
PubMed1991

Secondary caries related to various marginal gaps around amalgam restorations in vitro.

Secondary caries lesions were produced in vitro by immersing human tooth-blocks with amalgam restorations every third day for 4 weeks in glucose- or sucrose-containing broth inoculated with a strain of Streptococcus mutans. The lesions at the cavity walls were related to various standardized micro-spaces (0, 30, 40, 60 and 80 microns) around the restorations. When a thick, sucrose induced layer of plaque covered the margin, dentine caries was found in all cases where a gap was present (30 microns or more). In the presence of a thin, glucose induced layer of plaque, dentine caries was detected only in the specimens with 60 and 80 microns gap-widths. Caries lesions were detected on the outer free enamel surfaces in all specimens. Lesions in the enamel of the cavity walls were observed with polarized light in 46% in the presence of sucrose- and in 21% in the presence of glucose-induced plaque.

Dental Amalgam↗
PubMed1991

Dental health and dietary habits in Greek immigrant children in southern Sweden compared with Swedish and rural Greek children.

Dental health and dietary habits were surveyed in 40 Greek immigrant (GI) children, 2-8 years old, born and living in Helsingborg, Sweden; comparisons were made with 45 Swedish (S) and 54 rural Greek (G) children of the same age. The caries situation was virtually the same in the GI and the S group, where the primary teeth were caries-free in 31-33%, mainly children 2-3 years old. The G group had a higher incidence of decayed and filled tooth surfaces in both primary and permanent teeth than the other two groups and only 15% were caries-free in the primary teeth. The S group had the lowest gingival bleeding index. The distribution of the mutans streptococci and lactobacilli counts in saliva did not differ significantly between the three groups, except that the proportion of GI children with "not detectable" mutans streptococci was lower in either the S or the G group. The toothbrushing frequency was highest in the S group, followed by the GI group. Approximately 80% of the S children who brushed their teeth used a fluoride toothpaste compared to 50 and 55% respectively in the G and the GI group. The intake frequency for 5 out of 6 preselected snack-food items was highest in the G group. The carbohydrate content of the diet, including sucrose, was approximately the same in the three groups. Thus, the dental health and dietary habits of the Greek immigrant and the Swedish children were generally very similar, while the Greek rural children showed a less favourable cariological status.

Bacteria↗
PubMed1990

Oral electrochemical action after soft drink rinsing and consumption of sweets.

The aim of this study was to investigate the influence of pH changes in dental plaque and saliva on the magnitude of the galvanic current created when amalgam restorations make contact in the oral cavity. Ten persons with 46 contacts between amalgam fillings in all participated in the experiments. Potential, polarization, and pH measurements were performed before and after Coca-Cola and orange juice rinsing and intake of sweets, which were used as test products. Distilled water was used as a control. The measurements were performed 2, 5, 10, 20, and 30 min after the rinsing or intake. There was no statistically significant difference in the current magnitude after any test product or between the time intervals after the different products. The results indicated that changes of the plaque and saliva pH for a short time after food and soft drink intake do not influence the magnitude of the galvanic current flowing between amalgam restorations in contact.

Adult↗
PubMed1990

Effect of pH on acid production from sorbitol in washed cell suspensions of oral bacteria.

The acid production from sorbitol and glucose was studied under anaerobic conditions in resting cell suspensions of bacteria from the predominant sorbitol-fermenting human dental plaque flora, belonging to the genera Streptococcus, Lactobacillus and Actinomyces. The acid production activity of the bacterial cells was followed by titration with alkali, at environmental pH 7.0, 6.0 and 5.0 after addition of carbohydrate solution. The metabolic end products formed in the suspensions were analyzed thereafter by isotachophoretic and enzymatic methods. The results showed that sorbitol was fermented at a slower rate than glucose. Lowering the environmental pH decreased the acid production activity from the two carbohydrates. Compared with glucose, the catabolism of sorbitol was affected to greater extent by the pH conditions. The total amount of acids formed from sorbitol was considerably less than from glucose. Lactic acid, which was the major end product in glucose-challenged suspensions, was produced only in low concentrations from sorbitol by all strains tested. The ratio strong (formic + lactic)/weak acids was moreover lower for sorbitol than for glucose. The present results further illustrate some of the mechanisms behind the low cariogenic potential of this sugar substitute.

Acetates↗
PubMed1990

Sorbitol adaptation of dental plaque in people with low and normal salivary-secretion rates.

Caries-related bacteriological and biochemical factors were studied in 12 persons with low and 11 persons with normal salivary-secretion rates before and after a four-week period of frequent mouthrinses with 10% sorbitol solution (adaptation period). After the adaptation period, an increase in total numbers of sorbitol-fermenting bacteria and mutans streptococci was found in plaque samples from both groups. The pH drop in dental plaque in situ after a mouthrinse with sorbitol was more pronounced after the adaptation period, especially in the group with the low salivary-secretion rate. Increased acid production in plaque from sorbitol was also observed in the two groups in vitro. The composition of the fermentation end-products was affected by the sorbitol exposure. It is suggested that in subjects with diminished natural protection against caries development, such as patients with low salivary-secretion rate, a cariogenic potential of sorbitol should be considered when this polyol is included in products that might be used frequently.

Adaptation, Physiological↗
PubMed1990

Dental caries in players belonging to a Swedish soccer team.

Since dental caries is associated with frequent use of sugar-containing products and since there is a potential risk for such a consumption among sportsmen, we conducted a clinical study of a group (n = 30) of 17-30-year old elite soccer players, including DFS and various caries-related factors, such as plaque index, numbers of cariogenic microorganisms in saliva and sugar intake frequency. Each player was asked to identify one friend of the same age, sex and social background but not active in any sport (n = 28). The mean values for DFS, plaque index, mutans streptococci and lactobacilli were less favourable for the players, but none of the differences were statistically significant, except for the dietary score (p less than 0.05). Thus, soccer players on an elite level seem to have a somewhat higher risk to develop dental caries than nonplayers. However, their regular use of fluoride-containing toothpaste probably to some part compensates for this increased risk.

Adolescent↗