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Biomedical subjects

D Bernard

Publications and source records attributed to D Bernard.

At least 163 records · Page 9Linked to original sources
PubMed1981

[Spectral analysis of frequencies by conventional Doppler effect examination of the supra-aortic trunks (author's transl)].

Using a directional Doppler (4 MHz) coupled to a frequency analyser, authors investigate the supra-aortic trunks on 90 patients documented by arteriography. The analyser is made of a 16 filter bank system giving a spectrum composed of 16 frequency bands within range of 160 Hz to 4,800 Hz. Data analysis is made on a computer using the comparison means test and the discriminant analysis. Authors compare frequencies on normal common carotid arteries between a group (N = 102) with internal and external carotid arteries free of lesions on one hand, and a group (N = 75) with stenosis or occlusion of internal and/or external carotid arteries on the other hand. They don't note any significant difference for each on of the 16 frequency bands. Comparison of frequencies between normal subclavian arteries (N = 115) and subclavian arteries with proximal stenosis or occlusion (N = 24) shows a significant difference concerning the following bands : F12, F14, F15, F16 (p = 0.05), F13 (p = 0.01). Comparison of frequencies between normal internal carotid arteries (N = 108) and stenosed internal carotid arteries (N = 57) shows significant difference concerning : F11 (p = 0.05), F7, F8, F9, F12, F13, F14, F15, F16 (p = 0.01). On the other side, the discriminant function distinguishes a normal internal carotid artery from a stenosed internal carotid artery in 90% of cases, whatever the stenosis degree is. A discriminant function, added to this analyser, could obtain a frequency analysis easier and less expensive than by fast Fourier transform.

Arterial Occlusive Diseases↗
PubMed1979

[Posterior rectotomy indications for villous tumors].

The posterior (Kraske) approach to the surgical management of villous tumours of the rectum was used in 12 patients. One patient died in the postoperative period and in six others there were complications (wound infection in three, wound infection and rectal hemorrhage in one, wound dehiscence in one and cellulitis in one), but there was not a single fistula. This approach represents an easy and well-tolerated operation especially in older patients who are otherwise poor operative risks. The posterior approach is also excellent for excising lesions of the mid-rectum that may be too bulky for endoscopic removal and too proximal for their excision through the dilated anus. The procedure is not appropriate for malignant tumours and the benign nature of these tumours is best appreciated preoperatively by digital palpation; however, confirmation of their exact nature requires microscopic examination of the whole lesion.

Adenoma↗
PubMed1979

Colorectal neoplasm: a rare complication of ureterosigmoidostomy.

A 24-year-old woman had a rectal neoplasm which occurred 20 years after she had undergone ureterosigmoidostomy for exstrophy of the bladder. Only 41 cases of bening or malignant tumours of the large bowel developing after ureterosigmoidostomy have previously been reported in the literature. Adenocarcinoma of the colon is most frequently found and can develop even after urine has been diverted away from the colon. The presenting symptoms are either those of ureteral obstruction or of colorectal neoplasm. This rare complication remains intriguing and the possible pathogenetic mechanisms are discussed.

Adult↗
PubMed1978

Recurrent duodenal ulcer.

In the past 6 years 26 patients underwent operation for recurrent duodenal ulcer after what was considered to be an "adequate" initial operation. In such patients it is necessary first to demonstrate the recurrent ulcer and then to determine its cause. Endoscopy was the best means of confirming the diagnosis. The cause of recurrence was determined by tests for gastric acid secretion; 70% of patients had hyperacidity and 80% had positive results of the Hollander test. Treatment is always surgical but varies depending on the type of initial surgery, the primary cause of recurrence and the condition of the patient. Ten patients underwent vagotomy, 12 had vagotomy with antrectomy and 4 had antrectomy alone. There were no operative deaths but nine (35%) patients experienced 11 significant postoperative complications.

Adult↗
PubMed1977

[Study of hemostasis factors in nephrotic syndrome. Pathogenic interpretation and therapeutic deductions].

Thrombo-embolic accidents are extremely common during nephrotic syndrome (8 p. 100). They share the garvity of thrombo-embolic accidents occurring under other circumstances (20 p. 100 mortality). They are accompanied by numerous disturbances in clotting factors the mechanisms of which are discussed. Nevertheless the study of these disturbances does not make it possible to predict the onset of a thrombo-embolic problem. By contrast, the degree of hypoalbuminaemia is significantly correlated with the thrombotic risk (p. 0.001) and serves as an indication for the necessity of preventive heparin therapy, in the form of calcium heparinate. In this way the authors have been successful in eliminating the thrombo-embolic risk in association with nephrotic syndrome.

Blood Cell Count↗
PubMed1977

[Rectal fistula].

It is now possible to define with precision the pathogenesis of anal fistulous abscesses. Common as well as rarer types of fistulas can be classified according to the anatomy of the anal canal. Identification and proper treatment of these conditions need a thorough systematic approach; knowledge of their symptomatology, anatomy and pathology is of paramount importance, and successful treatment is based on accepted surgical principles. A detailed description of the management of these fistulas is presented. Factors explaining recurrences are also mentioned.

Abscess↗
PubMed1976

[Association of monoclonal gammopathy with chronic glomerulonephritis and autoimmune hyperlipemia. Course of disease during therapy].

A case of benign monoclonal gammapathy associated with an auto-immune hyperlipidaemia and a chronic glomerulopathy is reported. Extraction of the monoclonal immunoglobulin made it possible to demonstrate its anti-lipoprotein antibody activity. Parallel changes in serum lipid levels and monoclonal immunoglobulin levels under the influence of melphalan confirmed the direction relationship between the lipid and protein disorders. The pathogenesis of the glomerulopathy and of the massive and prolonged activation of the classical complement pathway is more difficult to affirm. It is nevertheless possible that the renal involvement is due to an auto-immune complex disease.

Adult↗
PubMed1976

[Humoral immunity and blastic transformation of lymphocytes in trisomy 21].

Studies of immunologic parameters in 52 children with trisomy 21 revealed that -the changes in serum immunoglobulin patterns were minimal, although some delay in the age-dependent rise of IgG concentration was observed; -lymphocyte reactivity to phytohemagglutinin showed a shift with maximal 3H-thymidine incorporation at low PHA concentration; -presence of HBs antigen at an increased incidence, possible existence of anti-thyroid antibodies in serum of trisomy patients and also in that of their parents, abnormalities in phagocytosis, illustrate that trisomy 21 can be associated with multiple immunologic dysfunctions.

Adolescent↗