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Biomedical subjects

D Bergqvist

Publications and source records attributed to D Bergqvist.

At least 433 records · Page 24Linked to original sources
PubMed1987

Endometriosis in the uterosacral ligament giving orthopedic symptoms through compression of the sciatic nerve and surgically treated via an extraperitoneal approach keeping the pelvic organs intact.

Sciatic pain in a young woman was not relieved by orthopedic treatment. The gynecologist found a large hard tumor-like mass in the uterosacral ligament extending to the pelvic wall. Cytologic examination of fine needle aspirate indicated an endometriotic lesion. The large tumor-like mass was extirpated by an extraperitoneal technique and the pain disappeared.

Adult↗
PubMed1987

Coagulation and fibrinolytic reactions in experimental porcine septic shock: pretreatment with different antiplatelet factors.

The aim of this study was to investigate the influence on various hemostatic factors (alpha 2-macroglobulin, antiplasmin, antithrombin III, prothrombin-proconvertin activity, fibrinogen concentration, ethanol gelation test, and fibrinolytic activity on fibrin plates) of bacteremic shock in swine and the influence on these factors of drugs interfering with platelet function. Anesthetized pigs were given live Escherichia coli intravenously (n = 49) or Ringer's solution (n = 7) and were monitored for 3 hours. Pretreatment was given with indomethacin (n = 6), the TxA2 inhibitor UK 38 485 (n = 7), the prostacyclin analogue ZK 36 374 (n = 7), the 5HT antagonist ketanserin (n = 6), or ketanserin combined with UK 38 485 (n = 9) or dipyridamole (n = 8). Septic shock developed in all E. coli animals. There were decreased levels of platelets and leukocytes and activation of the coagulation/fibrinolytic systems by E. coli. Except for a slight attenuating effect on the antithrombin III (ketanserin and dipyridamole) and alpha 2-macroglobulin (ketanserin) decreases, there were no significant effects of the drugs. It is concluded that live E. coli induced several changes within the coagulation and fibrinolytic systems. Only minor effects were seen when different drugs influencing platelet function were given.

Animals↗
PubMed1987

Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats.

The influence of standard heparin or low molecular weight (LMW) heparin on healing of abdominal wounds and colonic anastomoses was studied in rats. Subcutaneous injection of 1 XaI U/g b.w. of standard or LMW-heparin or 0.5 ml physiologic saline was given 12 hours preoperatively and daily for 3 or 7 days postoperatively. Breaking strength of the abdominal wound and the anastomosis was measured, as were haemoglobin and albumin in serum. Hydroxyproline as a measure of collagen and tissue dry weight was determined in standardized segments of colonic wall adjacent to the anastomosis. Except for significant increase in breaking strength of the anastomosis after 7-day injection of LMW heparin, no differences in the parameters of wound healing were found after 3 or 7 days. In rats receiving standard heparin there was increased bleeding tendency (reduced haemoglobin) compared with the LMW-heparin group and the controls. The administered heparin thus did not negatively influence healing, and standard and LMW-heparin did not differ in this respect.

Abdomen↗
PubMed1987

Complications after percutaneous transluminal angioplasty in the iliac, femoral, and popliteal arteries.

During a 5-year period percutaneous transluminal angioplasty (PTA) was attempted in 134 iliac, femoral, and popliteal arteries in 127 patients. Complications were systematically registered and classified as major, minor, and radiologic. Seventeen major complications (12.7%), including three deaths, occurred, as well as five minor (3.7%) and 13 radiologic complications (9.7%). The last group showed no clinical symptoms. The frequency of complications in our series is high compared with that found in a survey of 13 studies with 2043 patients. The most marked discrepancy was our high frequency of septic symptoms. A mortality rate of 2.2% was also higher in our series, but we have consequently registered the 30-day mortality rate to make comparisons with surgical series relevant. Radiologic alterations are usually not reported in other series probably because they are regarded as a part of the method, but we consider these alterations as potentially dangerous and important to report because they can result in clinically relevant complications. Because of the complications PTA should only be performed in centers in which complications can be optimally treated.

Adult↗
PubMed1987

Pulmonary vascular response to live Escherichia coli: influences of different antiplatelet substances.

The aim of this study was to investigate whether pretreatment with drugs that interfere with platelet functions in different ways could modify the pulmonary vascular response in a porcine septic shock model. Septic shock was induced by i.v. infusion of live Escherichia coli bacteria. Bacteriemic animals were divided into five groups: untreated or pretreated with a thromboxane-A2 synthetase inhibitor (UK 38 485), a serotonin-receptor antagonist (ketanserin), a combination of these two drugs, or a platelet antiaggregating drug (dipyridamole). E. coli induced significant pulmonary hemodynamic and respiratory changes. The pulmonary responses to E. coli infusion were attenuated after pretreatment with UK 38 485 but unaffected by prior administration of ketanserin or dipyridamole. The combined pretreatment did not attenuate the pulmonary hypertension or other pulmonary responses to E. coli more than UK 38 485 alone. Dipyridamole did not alter the pulmonary circulation after bacterial infusion. It was concluded that thromboxane-A2 is an important, but not the only, mediator of the pulmonary vascular response in septic-shocked pigs and that factors such as serotonin and platelet aggregability seem to be of minor, if any, importance for the hemodynamic response.

Animals↗
PubMed1987

Arterioenteric fistula. Review of a vascular emergency.

Fistula between the arterial system and the gastrointestinal tract is rare, but can give rise to life-threatening bleeding. The fistula may be primary or secondary. A review of cases in the literature is presented and a classification based on type and cause is proposed. The collected series comprised 249 cases of primary, and 631 of secondary arterioenteric fistula. The dominant cause was aortic aneurysm in the primary and vascular reconstructive surgery in the secondary cases. As the prognosis is poor and aortoiliac reconstructive surgery is increasingly performed, awareness of arterioenteric fistula as a possible cause of gastrointestinal haemorrhage is important.

Arteriovenous Fistula↗
PubMed1987

Treatment of arterial lesions after radiation therapy.

Of 1,724 patients who underwent peripheral vascular operation, 12 (0.7 per cent) underwent radiation therapy of the areas including the relevant arteries one and one-half to 28 years (a mean of 15 years) previously; one patient had carcinoma of the breast, three had tumors of the neck and eight patients had malignant gynecologic disease. One patient with an occluded carotid artery was not actively treated, two underwent percutaneous transluminal angioplasty and the remaining patients underwent different types of vascular reconstructions. These patients frequently have other radiation lesions as well with involvement of the skin, bladder or intestine, which may make them problematic from a surgical point of view. Extra-anatomic reconstructions or percutaneous transluminal angioplasty can be recommended. One patient died of malignant disease three years after arterial operation. Otherwise, the results of follow-up study for these patients did not differ from other patients who underwent arterial reconstruction.

Aged↗
PubMed1987

Atherosclerotic aneurysm of the deep femoral artery. Case report.

Three cases of atherosclerotic aneurysm of the deep femoral artery are described. They demonstrated the differing presentations of atherosclerotic femoral aneurysm, viz. as "asymptomatic" pulsating tumour or with manifestations of distal ischaemia or rapid growth and rupture. A search of the literature revealed 12 cases of atherosclerotic aneurysm in the deep femoral artery, and additionally 11 mentioned in review articles on femoral aneurysm. Notably, five of the 15 (including the 3 here described) cases of deep femoral artery aneurysm presented with rupture, an incidence higher than has been reported for aneurysm of the common or superficial femoral artery. The reason probably is that deep femoral aneurysms are more difficult to diagnose before they have reached a size carrying higher risk of rupture. A more aggressive approach, with operation soon after establishment of the diagnosis, is therefore proposed.

Aged↗
PubMed1987

Carotid artery injury caused by blunt cervical trauma. Case report.

Three cases of carotid artery injury following blunt cervical trauma are reported and the literature is reviewed. The condition carries high morbidity and mortality rates, due to occlusion of the internal carotid artery. The diagnosis is often delayed, as the symptoms of carotid injury frequently are mistakenly attributed to head injury. The insidious course, with neurologic deficit developing in an alert patient prior to lowering of consciousness, distinguishes blunt carotid artery injury from head injury. Aortic arch angiography is crucial for the diagnosis, and should be frequently performed in patients who have sustained blunt cervical trauma. Normal computed tomography of the brain does not exclude ischaemic cerebral infarction, visualization of which requires several days. Tomography of the neck following intravenous injection of contrast medium may be useful for demonstrating occlusion of the carotid artery. Heightened awareness of this injury is important for early diagnosis. Immediate revascularization may improve the poor prognosis.

Accidental Falls↗
PubMed1987

Macromolecular permeability increase following incomplete ischemia in the hamster cheek pouch and its inhibition by terbutaline.

The microvascular permeability increase during the reperfusion after incomplete ischemia in the everted hamster cheek pouch preparation was measured by intravital microscopy. FITC-dextran 1500,000 was given i.v. as tracer of macromolecular leakage. Incomplete ischemia of the left cheek pouch was obtained by occlusion of the ipsilateral carotid artery, its external branch and the contralateral external carotid artery. Reperfusion after thirty minutes of incomplete ischemia resulted in a fully reversible increase in the number of FITC-dextran leakage sites (leaks) from 0 to 68 +/- 18 in 7 hamsters. The response to a second period of ischemia, starting one hour after the first ischemia period, was significantly smaller (9 +/- 5 leaks). Local treatment with terbutaline (10(-6) M), a beta 2-receptor agonist, abolished the permeability response to ischemia almost completely (0.5 +/- 0.3 leaks, n = 6). Local application of histamine (2 X 10(-6) M) at the end of the experiments gave a response that was in accordance with that seen in hamsters not subjected to ischemia. These results were compared with those obtained from previous studies in our laboratory with a complete ischemia model and it appears as these two methods, incomplete and complete ischemia, give similar results.

Animals↗
PubMed1987

Obturator hernia--clinical significance of radiologic diagnosis.

Obturator hernia was revealed in 15 of 850 patients undergoing herniography for investigation of groin pain of obscure cause. The 15 patients (4 men, 11 women) were retrospectively analyzed in regard to symptoms, treatment and clinical outcome. They were of normal physique and with median age 56 years. Surgical exploration was performed in five cases, but confirmed presence of hernial sac in only two. Even after hernial repair these two patients still had symptoms. Two of the three patients with negative surgical findings were asymptomatic postoperatively. Of the ten patients without surgery, six had only minor symptoms and in four the symptoms were in the contralateral groin. The study showed that herniography in patients with groin pain can reveal small obturator hernias, but these hernias are mostly without significance for the patient's symptoms.

Adult↗