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Biomedical subjects

D Berger

Publications and source records attributed to D Berger.

229 records · Page 13Linked to original sources
PubMedDate not supplied

Immediate and late outcomes of transarterial coil occlusion of patent ductus arteriosus in dogs.

Records from dogs (n = 125) that underwent attempted transarterial coil occlusion of patent ductus arteriosus (PDA) at the University of California, Davis, between 1998 and 2003, were reviewed, and a subset of these dogs (n = 31) in which the procedure was performed at least 12 months earlier were reexamined to determine long-term outcome. Coil implantation was achieved in 108 dogs (86%). Despite immediate complete ductal closure in only 34% of dogs, the procedure was hemodynamically successful as evidenced by a reduction in indexed left ventricular internal diameter in diastole (LVIDd; P < .0001), fractional shortening (P < .0001), and left atrial to aortic ratio (LA: Ao; P = .022) within 24 hours. Complete ductal closure was documented in 61% of dogs examined 12 to 63 months after coil occlusion. Long-standing residual ductal flow in the other 39% of dogs was not associated with increased indexed LVIDd or LA: Ao and was not hemodynamically relevant. Repeat intervention was deemed advisable in only 4 dogs with persistent (n = 1) or recurrent (n = 3) ductal flow. Complications included aberrant embolization (n = 27), death (n = 3), ductal reopening (n = 3), transient hemoglobinuria (n = 2), hemorrhage (n = 1), aberrant coil placement (n = 1), pulmonary hypertension (n = 1), and skin abscessation (n = 1). Serious infectious complications did not occur despite antibiotic administration to only 40% of these dogs. Transarterial coil occlusion was not possible in 14 dogs (11%) because of coil instability in the PDA and was associated with increased indexed minimum ductal diameter (P = .03), LVIDd (P = .0002), LVIDs (P = 0.001), and congestive left heart failure (P = .03) reflecting a relatively large shunt volume.

Animals↗
PubMedDate not supplied

[Psychological preparation of disclosing diagnosis and therapy in patients with malignant hematologic diseases].

The article deals with the experience in psychological preparation of patients with haematologic malignant disorders for diagnosis ant therapy. Psychological assessment and preparation of the patients, including members of their families, were carried out in the Institute of Haematology of the University Clinical Centre in Belgrade, from November 1990 to the present day. Over a period of less than 11 months, the psychological preparation was carried out in 146 hospitalized patients in whom leukaemia was diagnosed. The same was done with 292 members of their families. This kind of clinical practice requires a team work which involves: a clinical psychologist, the head of the unit, and medical doctors who treat the patient during hospitalization.

Counseling↗
PubMedDate not supplied

[Therapeutic termination of pregnancy. Diagnosis and protocols. 54 cases].

The authors present 54 cases histories of therapeutic terminations of pregnancy. The mean age of the patients was 28.6 years at the time of diagnosis with the following in indications for the antenatal diagnosis in order of decreasing frequency: clinical history, age of the mother, seropositive for toxoplasmosis or rubella, a high fetal alpha protein level and ultrasound signs. They highlight the usefulness of ultrasound in reaching a decision as to whether pregnancy should be terminated (as it was in 25 cases out of 49) and the predominance of diagnoses of karyotype abnormalities. They also compare the various prostaglandin s used in this study (analogs of PGE1 and PGE2, diniprost). Their results, in accordance with the literature were good for gemeprost and sulprostone with expulsion in 29 out of 32 cases within 24 hours and in 9 cases out of 11 within 20 hours respectively.

Abortifacient Agents, Nonsteroidal↗
PubMedDate not supplied

Developing health education materials for inner-city low literacy parents.

The question of identifying and treating childhood illness confronts all new parents. Misconceptions often lead parents to manage illnesses in their young children inappropriately through overly aggressive treatment or insufficient attention. This responsibility is especially challenging for low-income new parents who lack the literacy levels needed to understand and use much of the existing health education literature and who are without access to health facilities and providers. In response to a perceived need for health information directed at low-income, low-literacy parents, students from the University of California at Los Angeles School of Public Health created an easy-to-use reference booklet called "A Parent's Guide: When Your Child Is Sick." The booklet's aim is to assist parents in treating common childhood illness and identifying more serious diseases requiring medical attention. A comprehensive and manageable amount of information is provided in the booklet. Behaviors and issues covered include (a) recognition of symptoms, (b) actions that could be taken in the home, (c) medicines that could be administered, and (d) recommendations on how persistent problems might be handled.

Child↗
PubMedDate not supplied

[Iatrogenic esophageal perforation-- severe complication in the care of premature infants].

Two preterm neonates were referred to our institution, one with suspected oesophageal atresia and one with the definite diagnosis of oesophageal atresia for further treatment. Diagnostic procedures identified an iatrogenic perforation of the oesophagus which was caused by a feeding tube in both patients. The treatment was based on broad-spectrum antibiotic therapy and parenteral nutrition. The perforations healed without long term sequelae.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Use of the Karnofsky index in the evaluation of patients with acute leukemia].

The longitudinal study of prospective character was performed during the treatment with the aim to test if Karnofsky's index is an instrument susceptible to the changes in performance status in the population of adult patients with acute leukemia. Performance status points out the person's independence in every day activities and personal care, and more widely, the independence in social and other activities. The aim was to establish its changes in adult patients and its possible prognostic value for the therapy success. The prognostic value of person's activity level was confirmed for the survival length and the lasting, but not for the complete remission achievement. It was concluded that Karnofsky's index was sensitive only for large changes in functional status of acute leukemia patients.

Acute Disease↗
PubMedDate not supplied

The p53 gene in soft tissue sarcomas: prognostic value of DNA sequencing versus immunohistochemistry.

BACKGROUND: The aim of this study was to compare sequencing and immunohistochemistry (IHC) for their ability to detect p53 mutations and to assess their prognostic value in soft tissue sarcomas (STS). MATERIAL AND METHODS: 146 STS samples were investigated by single strand DNA conformation polymorphism (SSCP)-sequencing for p53 mutations. Additionally, IHC with five p53 antibodies (CM-1, Pab1801, Pab240, DO1, DO-7) was performed. RESULTS: In 65 to 131 tumor samples (44.5% to 90.4%) elevated levels of p53 protein were recorded by IHC, depending on the antibody applied. Sixteen out of 146 STS tumor samples (11%) had p53 gene mutations. 13 cases (81.2%) of the 16 tumors with p53 mutations could be detected by DO-1. However, of the 93 DO-1 positive tumors 79 were negative by SSCP-sequencing analysis. Using multivariate regression analysis (Cox proportional hazards model) both p53 mutations (non-frameshift mutations) and IHC detection of p53 protein overexpression were prognostic predictors for poor survival. CONCLUSIONS: This study suggests that IHC is valuable for assessing p53 mutations in STS, but sequencing provides additional important information on the molecular characteristics of the alterations.

DNA, Neoplasm↗