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Biomedical subjects

D Berg

Publications and source records attributed to D Berg.

At least 199 records · Page 11Linked to original sources
PubMed1981

Hepatocellular enzyme patterns and hepatitis B virus exposure in multitransfused young and very young hemophilia patients.

Thirty-eight children with severe hemophilia A, 11 years of age and under, were evaluated by initial and follow-up liver function tests (LFTs) in relation to age of onset of transfusion therapy. Each child had at least two complete evaluations within one year for a follow-up period of at least one year. The mean number of exposure days was 36 with a mean of 275 units of factor VIII per exposure day prior to initial LFTs. At initial testing, 30% of patients demonstrated antibody to HBsAg and 39--51% at least one abnormal serum enzyme level (AST, ALT, LDH). During an average follow-up period of 34.8 months, two children developed HBsAg-positive icteric hepatitis. Of those initially serologically negative for HBsAg or antibody, 44% became antibody-positive. Intermittent abnormalities of at least one serum enzyme were observed in 79% of the patient group, with 13% and 8% being persistently normal and abnormal. Eleven children born after January 1976, receiving only third-generation RIA-tested products for HBsAg, constituted a subgroup. Although only one child at first assessment had evidence of hepatitis B virus exposure, 55% had elevated ALTs, indicating considerable frequency of non-A, non-B hepatitis in this very young group.

Child↗
PubMed1981

[Proof of beta-2-adrenergic activity of etilefrin (effortil) via aimed recording of its tocolytic action (author's transl)].

In 21 normal deliveries the intrauterine pressure was measured continuously during the first stage of labor. Thus the tocolytic efficiency of Etilefrin was revealed. Intensity and duration of the tocolytic effect were related to the dose. Pressure and frequency of the contractions were diminished. Therefore these results are conclusive that Etilefrin, generally given for its alpha- and beta 1 mimetic effects, has an additional beta 2-mimetic and tocolytic component.

Adrenergic beta-Agonists↗
PubMed1981

Mixture of bupivacaine 0.5% and hyperbaric mepivacaine 4% for spinal anaesthesia.

Recent research shows that using more than 12.5 mg bubivacaine for spinal block may possibly be harmful. A dose of 12.5 mg isobaric bupivacain does not always establish a spinal anaesthesia sufficient for hip or lower abdominal surgery. However short acting local anaesthetics of sufficient effectiveness usually do not last long enough for those operations. We evaluated a method using the subarachnoid injection of 2 to 3 (4) ml of an equal parts mixture of isobaric bupivacain 0.5% and hyperbaric mepivacaine 4%. We generally achieved good spinal anaesthesia with quick onset and long duration of action making longer operations such as total hip endoprothesis possible. The duration of action was longer (130 min) than that of plain mepivacaine (90 min) and shorter than that of plain bupivacain.

Aged↗
PubMed1980

Comparative study of quantitating 99mTc-EHDP uptake in sacroiliac scintigraphy.

Quantitative sacroiliac (SI) scintigraphy was performed 3 h after an i.v. injection of 16 mCi 99mTc-EHDP. The resulting images were recorded and processed and on an ON data system 150. Five technical approaches for objective digital assessment of abnormal uptake of the tracer at the sacroiliac joints were employed. SI indexes from the ratio of radioactivity in the SI joints and in the os sacrum, determined either by a region-of-interest technique or by a profile-scan technique measuring the maxima of the curve over a defined base line, proved to be the best parameters in discriminating normal from abnormal uptake of the radiotracer in the SI joints. The quantitative scan technique appears to be useful as an objective tool in interpreting SI scans.

Back Pain↗
PubMed1980

Duty to recall.

In the last few years there has been a dichotomy in the law vis-à-vis health care providers. The state legislatures are imposing statutory barriers which impede the ability of patients to bring malpractice suits against health care providers. On the other hand, the courts are increasing the spectrum of legal causes of action available to patients in the pursuit of their rights against physicians and other providers of care. The duty to warn patients, even third party strangers, of foreseeable and serious dangers inherent in care and management has been expanding in recent years. The latest is the "duty to recall" patients, past and present, who have been exposed to danger resulting from treatment (and probably diagnosis as well). We report here such a case and the "law" incident thereto.

Humans↗
PubMed1980

Blood volume and hematocrit in various organs in newborn piglets.

Plasma volume and red cell mass of various organs in piglets aged 24 hr (n = 7) and 7 (n = 6), and 14 (n = 6) days were measured using 99mTc-labeled albumin and 51Cr-labeled red blood cells. Organ activities were counted in a whole-body counter. Blood volume and hematocrit were calculated. The blood volumes in microliters/g varied markedly between various organs. The lowest blood volumes at 24 hr of age were found in skin (21.9 +/- 5.0 microliter/g), brain (33.3 +/- 8.4), and skeletal muscle (35.5 +/- 7.4). The highest values at this age were noted in liver (670.0 +/- 89.1), lung (533.8 +/- 80.7), spleen (332.0 +/- 82.8), and kidney (300.6 +/- 55.5). Blood volumes of about 150 microliters/g were observed in heart muscle and thyroid gland and those of about 100 microliters/g in thymus and gastrointestinal tract. The total blood volume was 100.2 +/- 3.9 microliters/g at 24 hr and remained unchanged during the first 2 wk of life. A significant decrease in relative blood volume with growth was noted in liver and lung (P less than 0.01), and in skeleton (P less than 0.05). The blood volume, contained in the great vessels outside the organs, increased from 29.5 +/- 5.5% of total blood volume at 24 hr to 31.2 +/- 5.7% at 7 days and to 38.2 +/- 7.5% at 14 days of life. The total body-venous hematocrit ratio was about 0.84. Accordingly, tissue hematocrits of most organs were below the venous hematocrit. Only in spleen was the tissue/venous hematocrit ratio (TH/VH) higher than 1.0. TH/VH of brain, gastrointestinal tract, thyroid gland, and thymus approached unity. The lowest TH/VH was found in kidney (0.54 +/- 0.08 at day 1). In skin, the TH/VH decreased from 0.98 +/- 0.10 to 0.82 +/- 0.07 during the first 2 wk of life.

Animals↗
PubMed1978

[Angiographic examinations of the stomach following Billroth II resections with special reference to the gastro-jejunostomy (author's transl)].

The arterial blood supply of the anastomosis in 6 stomach resected dogs (Billroth II) is examined by common angiographic technique in vivo, microangiography, and microscopy. In all animals there are at the site of the gastrojejunostomy bizarre tortuous vessels which cross the anastomosis. These arteries have a diameter between 50 to 2000 mu. They are newly formed vessels which cannot be demonstrated by common coeliaco- and mesentericography in animal experiments or in patients.

Angiography↗
PubMed1977

Critical remarks on external cephalic version under tocolysis. Report on a case of antepartum fetal death.

SALING and MULLER-HOLVE recently proposed an improved method of external cephalic version brought about a renewed interest in this obstetric procedure. In spite of the undisputed advantages in individual cases we posed the following questions: 1. The extent of the decreased cesaerean section rate 2. The fetal risk We estimate a decrease of cesarean sections by about 1.5% under the assumption that a breech presentation in primiparae is an indication of cesarean section and that 70% of the version attempts would be successful. The estimate includes some cases of multi-parae breech presentations which would have been operated without external version. The resulting decrease of the cesarean section rate is generally not very important and has a greater impact only in individual cases. We have some misgivings about the fetal risk. We report here on a case of intrauterine fetal death after failed external version. A 28 year-old primiparae without known pregnancy complications was admitted with a breech presentation in the 37th week of gestation. The biparietal diameter of the fetal head was appropriate and the placenta was posterior. Cardiotocogram before and after the unsuccessful version were in part misinterpreted. Seven hours after the version the fetal death was confirmed. Histological examination of the placenta showed a severe dissociated maturation disturbance in addition to a 10 X 8 cm large abruptio which had not been noted clinically. A prediabetes was suspected. The fetus itself showed no anomalies. This was interpreted as a severely placentogenically prestressed infant and prediabetes. The extent of the placental disturbance was unknown and had not been appreciated from the ultrasound examination. The placenta had acute infarcts and a circumscript abruption. The CTG was misinterpreted in part. In another case of version the postoperative cardiotocogram showed pathologic patterns. The birth occurred three weeks later without problems with a well child and an umbilical artery pH of 7.31...

Abruptio Placentae↗
PubMed1976

"Doughnut" sign in brain scanning.

The significance of the "doughnut" sign at present is relegated to characterizing the morphology of a lesion. The use of the "doughnut" sign in differential diagnosis should not be attempted except in specific clinical contexts, and never excluding other evidence. The "doughnut" sign in scanning together with other studies such as angiography and computerized axial tomography gives additional characterizing data in the neuroradiologic evaluation of a patient.

Adult↗