Search PubMed⌕ Search

Biomedical subjects

D Benoldi

Publications and source records attributed to D Benoldi.

31 records · Page 2Linked to original sources

Retinol binding protein in normal human skin and in cutaneous disorders.

Circulating vitamin A is transported by a carrier termed retinol binding protein (RBP). Autoradiography and immunofluorescence studies showed that, in normal human skin, RBP is confirmed exclusively to the dermis. Following oral vitamin A loading, a large increase in dermal RBP but only a very small rise of serum RBP was found. Serum RBP was slightly decreased in eczema patients and markedly decreased in patients with porphyria cutanea tarda. Values in other dermatoses, including psoriasis, were normal.

Adolescent↗

[Retinoic acid and 5-FU mixture in the topical treatment of several skin diseases (author's transl)].

The need for safe and effective topical treatments is underlined by several clinical trials over the years treating miscellaneous dermatosis with many and heterologous drugs, sometimes on a simple empirical basis. In a recent study Robinson and Kligman claimed to have obtained satisfactory results treating several cases of actinic keratosis with an alternate regimen of retinoic acid and 5-FU. We wish to report an open-label pilot study using a simple and readily accessible combination of commercially formulated and available agents as 0,05% retinoic acid cream and 5% 5-FU cream over two groups of patients. Treatment consisted of bid application of sparing amounts of an equal parts combination of retinoic acid and 5-FU. The first group consisted of 7 patients affected by skin diseases associated with an altered epidermal keratinization (actinic keratosis, Darier's disease, seborrheic keratosis, phrynoderma and epidermodysplasia verruciformis). The patients were followed up for a period of 15 to 60 days and, as it might be expected, the results were quite good. The second group, on the contrary, consisted of 6 patients affected mainly by dermatosis involving the corium (LED, milium, colloid pseudomilium). The patients were followed up for the same period of time as the first group was, but the results were much less rewarding. Only a partial resolution of the process, which was followed soon after by a relapse, was noted. Finally we believe that this modified regimen of equal parts of retinoic acid and 5-FU has to be recommended in the topical treatment of the above mentioned dermatosis associated with an altered keratinization.

Drug Combinations↗

Erosive lichen planus involving the glans penis alone.

A 71-year-old white man was first seen in September 1978. He complained of an asymptomatic recurrent red patch, which had been slowly enlarging for two months on the glans penis. The patient stated he had a similar lesion a year before, which disappeared completely after one month of treatment with a topical corticosteroid. Physical examination revealed a single, glistening, erythematous, round patch, 1.5 cm in diameter, on the dorsal surface of the glans penis. The central area seemed somewhat depressed with minute erosions scattered over the lesion (Fig. 1). The inguinal nodes were not enlarged and nothing was found on the skin or other mucous membranes. The diagnoses entertained at that time were plasma cell balanitis, erythroplasia of Queyrat, fixed drug eruption, lichen planus, erosive balanitis and solitary plasmocytoma. Laboratory studies were normal. A biopsy of the lesion showed: ulcerated or atrophic epidermis; hypergranulosis; hydropic degeneration of the basal layer; many Civatte bodies within the lower epidermis and the upper zone of papillary dermis; occasional clefts between the epidermis and the dermis; a band-like infiltrate in the papillary dermis, which composed almost entirely of plasma cells, seemed to impinge on the epidermis (Fig. 2). The lesion was diagnosed as lichen planus, erosive type. The patch disappeared in about 4 weeks with topical steroids. No relapse has occurred after a year.

Aged↗

Tyrosinemia type II: a challenge for ophthalmologists and dermatologists.

Tyrosinemia type II was suspected in a 13-month-old child with recurrent photophobia, tearing, and hyperkeratotic lesions on the palms and soles. Laboratory tests revealed high tyrosine levels in blood and urine. All the symptoms promptly improved after the institution of a low tyrosine diet. We emphasize the importance of an early diagnosis in order to avoid the risk of mental retardation in these patients.

Cornea↗

[Norwegian scabies].

Explore the source record for details and available documents.

Adrenal Cortex Hormones↗