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Biomedical subjects

D Bennett

Publications and source records attributed to D Bennett.

At least 361 records · Page 20Linked to original sources
PubMed1975

Structural similarities between a product of the T/t-locus isolated from sperm and teratoma cells, and H-2 antigens isolated from splenocytes.

Molecules specified by the H-2-linked T/t locus in the mouse are expressed on H-2-negative cells such as early embryos, sperm, and teratoma cells. By means of enzymatic radioiodination of cells and immunoprecipitation of lysates with congenic antiserum, one of these molecules, known as F9, has been obtained from sperm and teratoma cells and compared to H-2 isolated from murine splenocytes. Our studies indicate that both H-2 and F9 have identical molecular weights and subunit structure, including the presence of a B2-microglobulin-like subunit. These findings, taken together with previous studies of TL alloantigens, suggest that a number of gene products of the 9th linkage group show structural homology with each other and, in addition, with immunoglobulin. The genes in question may therefore have arisen from a primitive gene concerned with cellular recognition.

Animals↗
PubMed1973

Surface antigens common to mouse cleavage embryos and primitive teratocarcinoma cells in culture.

Syngeneic antisera have been produced in mouse strain 129/Sv-CP males against the primitive cells of teratocarcinoma. These sera react specifically with the primitive cells and are negative on various types of differentiated teratoma cells derived from the same original tumor. They are negative on all other mouse cells tested, with the exception of male germ cells and cleavage-stage embryos. Thus, teratoma cells possess cell-surface antigens in common with normal cleavage-stage embryos.

AKR murine leukemia virus↗