Search PubMed⌕ Search

Biomedical subjects

D Bellis

Publications and source records attributed to D Bellis.

29 records · Page 2Linked to original sources
PubMed1990

Asbestos exposure and histologic cell types of lung cancer in surgical and autopsy series.

A case-control study was carried out on 41 surgical and 106 autopsy histological tissue samples of lung cancer in men, in order to investigate the relationships between asbestos exposure and cell type of pulmonary carcinoma. Both occupational history (obtained by interviews of surgical patients or of the next-of-kin for deceased subjects) and lung asbestos body content (determined by optical count after hypochlorite digestion and membrane filtration of lung tissues) were considered as asbestos exposure indicators. No significant relationships were found in the surgical series after adjustment for smoking. The autopsy series showed a trend towards an association between lung adenocarcinoma and asbestos exposure indicators and a markedly higher agreement between the 2 kinds of indicators than that observed in the surgical series.

Adenocarcinoma↗
PubMed1989

Minimal pathologic changes of the lung and asbestos exposure.

A group of 199 autopsy subjects was investigated for minimal pathologic pulmonary changes possibly resulting from asbestos exposure. According to the standards proposed by the Pneumoconiosis Committee of the College of American Pathologists, features consistent with asbestosis grade 1 (AG1) include findings of bilateral pleural plaques, high concentrations of asbestos bodies (ABs) in digested lung tissue, and a history of occupational risk. Similar changes without evidence of ABs on histologic section and referred to as small airway lesions (SALs) present a less well-correlated association. In this study, SALs showed significant differences when compared with the features observed in subjects without possible asbestos-related pulmonary fibrotic changes. Minimal bronchioloalveolar fibrotic changes with concomitant presence of ABs can be considered a mild pneumoconiotic lesion (AG1), and SALs may be regarded as an additional indicator of asbestos exposure.

Aged↗
PubMed1989

Atypical changes of respiratory epithelium after heart-lung transplantation. A case report.

Atypical changes of bronchial respiratory epithelium in a combined heart-lung transplantation recipient are reported. The occurrence of diffuse hyperplasia, squamous metaplasia and dysplasia with foci of disorganized structure of the respiratory epithelium is described. These epithelial changes in the bronchial tree were considered to have arisen after transplantation; their origin, significance and possible evolution are discussed.

Adult↗
PubMed1988

Leiomyoma and neurilemoma: report of two unusual non-epithelial tumours of the thyroid gland.

Two primary spindle cell tumours of the thyroid are described showing light microscopic features of leiomyoma and neurilemoma respectively. The origin from smooth muscle and nerve sheath was confirmed by both immunohistochemical reactions and ultrastructural findings. Review of the literature reveals only one case of leiomyoma and three cases of neurilemoma reported as developing within the thyroid gland. Our observations further support the view that leiomyoma and neurilemoma may occur at this unusual site and are recognizable entities.

Adult↗
PubMed1984

Coated and uncoated lung mineral fibres in subjects with and without pleural plaques at autopsy.

The lung concentration of coated and uncoated mineral fibres of more than 10 micron in length was determined by light microscopy in 57 autopsied subjects (23 out of which professionally exposed to asbestos) with pleural plaques but no other asbestos-related diseases. Comparisons were made with 57 controls matched for sex, age and smoking habits, who did not show any asbestos-associated diseases or history of previous occupational exposure. Subjects with pleural plaques had a median concentration of coated fibres consistently greater than that observed in those without. However, no substantial differences were found between the two studied groups when uncoated and total fibres were considered. The present study suggests that the factors related to the fibre coating and to the pleural plaque formation may be indirectly connected, but not necessarily restricted to the number and nature of the fibres, or to the professional or environmental conditions of exposure.

Adult↗
PubMed1983

Optical determination of coated and uncoated mineral fibers in lungs of subjects without professional exposure.

Coated and uncoated mineral fibers, more than 10 micron long, were counted by light microscopy in digested lung samples from 82 adult subjects without professional exposure. Up to about 150 coated and 12,500 uncoated fibers/g dry weight were found, without any correlation to sex, occupation and smoking habit. An association between counts of more than 1,000 fibers and ages over 50 was observed. The ratio of uncoated to coated fibers was very inconstant. Only the counts of both coated and uncoated fibers seem advisable for an optical evaluation of the possibly pathological mineral fiber burden in the lungs of unexposed persons.

Adolescent↗
PubMedDate not supplied

Screening of autopsy populations for previous occupational exposure to asbestos.

A screening procedure to select, in autopsy populations, subjects having a major likelihood of previous occupational exposure to asbestos is described. To test our necropsy population we searched for pleural plaques (PPs); the optical count of both lung asbestos bodies (ABs) and uncoated mineral fibers (UMFs) at least 10 microns in length was recorded. In the adult autopsy population studied in the Turin area, the predictive value given by a positive test for large-size PPs (mostly bilateral) was about 55%. This level of probability did not rise in relation to the AB counts, whereas an increase to over 75% was observed if more than 10,000 UMFs/g dry lung were present. In subjects without PPs or with small-size plaque lesions (mostly unilateral), predictive values of positive tests were 20 to 30% when ABs and UMFs were found to be below 100 and 10,000/g, respectively, and increased to approximately 40% if the AB count exceeded 500/g and to almost 70% for an UMF count above 100,000/g. In subjects without PPs or with small-size plaque lesions, the probability of being nonexposed was greater than 90% if neither ABs nor UMFs were found. This autopsy screening may be a reliable tool in selecting cases most probably related to occupational exposure.

Adolescent↗
PubMedDate not supplied

[An etiological definition of a case of mixed pneumoconiosis due to silicates and coal in the absence of anamnestic data].

A case of pneumoconiosis with unknown occupational history was examined both pathologically and mineralogically by means of a variety of techniques, including analytical scanning and transmission electron microscopy with electron diffraction and energy dispersive x-ray analysis, and electron resonance spectroscopy. The pathologic features consisted of a diffuse interstitial fibrosis with deposits of amorphous and crystalline particles and granulomatous reaction. The identification of minerals, mainly talc, halloysite, coal and chlorite, allowed a definite diagnosis of mixed silicate pneumoconiosis to be made. This is an example of complete pathologic, mineralogic and physico-chemical analysis of a case of pneumoconiosis.

Aged↗
PubMedDate not supplied

[Lung cancers attributable to asbestos on a pathological basis].

More than 1,000 asbestos bodies/gram dry weight (AB/gdw) were found by light microscopy in lung tissues, out of 429 non selected cases of pulmonary carcinoma (264 from surgery and 165 from autopsy). Asbestosis was detected by histology in 28% of the cases with AB > 1,000/gdw (in 19% of the surgical cases, and in 38% of the autopsy cases). A proportion of 4% of the total cases may be related to asbestos exposure.

Air Pollutants, Occupational↗