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Biomedical subjects

D Beatty

Publications and source records attributed to D Beatty.

23 records · Page 2Linked to original sources

Benign bronchoesophageal fistulas.

Two cases of benign bronchoesophageal fistula are presented which are representative of both congenital and acquired forms. The presentation of this relatively rare condition is characterized by recurrent cough especially after drinking liquids and is easily diagnosed by esophagogram. A high index of suspicion is required in all cases of recurrent cough and lung suppuration in order for this condition to be recognized. Benign bronchoesophageal fistulas are rare but the symptoms are often classic and the diagnosis is made easily once proper investigation is undertaken. Bronchoesophageal fistulas may be either congenital or acquired, with the latter being more common. The treatment is usually straightforward and prognosis is excellent for long-term survival. We present two cases of benign bronchoesophageal fistula.

Aged↗

Binding of epidermal growth factor (EGF) and insulin to human liver microsomes and Golgi fractions.

Microsomes and Golgi fractions were isolated from 13 human liver samples without local malignancy. Binding of insulin to microsomes (per cent per 0.5 mg protein) was 14.4 +/- 7.9% with two classes of receptors: K1 = 1.4 nM, R1 = 0.28 pmol/mg; K2 = 8.1 nM, R2 = 0.62 pmol/mg. The binding was insignificantly lower than in rats. Binding of EGF was only 3.4 +/- 1.7% with two classes of receptors: K1 = 1.4 nM, R1 = 0.06 pmol/mg; K2 = 10.8 nM, R2 = 0.22 pmol/mg; the binding was much lower than in rats (26.3 +/- 5.8%). Binding of insulin to Golgi fraction (per cent per 0.1 mg protein) was 5.5 +/- 0.4% with straight line Scatchard plot; Kd = 5.6 nM, Ro = 3.06 pmol/mg; it was only half of that found in rats. In one case of hepatoma, the binding of insulin to microsomes was normal but that of EGF very low.

Aged↗

Contingency contracting with heroin addicts.

The purpose of this study was to compare three conditions in a single-subject reversal design: no contract and no contingencies, a contract without contingencies, and a contract with contingencies. There were eight subjects who remained long enough in the halfway house environment to provide sufficient data for comparison across conditions. The results indicate that managerial behaviors (such as keeping a daily log and using a sign-in sheet) came under experimental control only during the "contract with contingencies" condition. Drug use did not come under control during any condition, apparently because adequate competing reinforcers were unavailable in this study.

Adult↗