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Biomedical subjects

D Beale

Publications and source records attributed to D Beale.

At least 73 records · Page 4Linked to original sources
PubMed1975

Ligandin.

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Animals↗
PubMed1969

Studies on the reduction of a human 19S immunoglobulin M.

1. Reduction of a 19s immunoglobulin M with 3mm-mercaptoethanol or 0.05-0.5mm-dithiothreitol followed by alkylation gave sedimentation patterns indicating products compatible with structures consisting of one, two, three, four and five 7s sub-units. This supports the concept of a five-sub-unit structure for immunoglobulin M. 2. Reduction with 0.125mm-dithiothreitol or 20mm-cysteine produced 7s sub-units that could not be dissociated into chains in m-propionic acid. 3. By labelling (with iodo[2-(14)C]acetic acid) the thiol groups liberated during reduction with 0.125mm-dithiothreitol, it was possible to identify the tryptic peptides involved in the disulphide bridges that link the 7s sub-units together (inter-sub-unit bridges). 4. By further reducing and labelling (with iodo[2-(14)C]acetic acid) the 7s sub-units produced by 0.125mm-dithiothreitol, it was possible to identify tryptic peptides derived from intra-sub-unit bridges. 5. Sub-units produced by reduction with 20mm-cysteine proved to be unsuitable for distinguishing between inter-sub-unit bridges and intra-sub-unit bridges. 6. The possible arrangement of the interchain disulphide bridges was deduced.

Alkylation↗
PubMed1968

Haemoglobin Stanleyville II (alpha asparagine replaced by lysine).

A fourth observation of haemoglobin Stanleyville II has been made. The affected person was a 17-year-old female from the north-eastern area of the Congo Republic, which is entirely inhabited by Nilotes. The amino-acid substitution was found to be a replacement of the asparagine residue by one of lysine in the 78th position of the 141 of the alpha-chain.

Adolescent↗