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D Bayer

Publications and source records attributed to D Bayer.

9 recordsLinked to original sources

[Suppression?].

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Clinical Competence↗

Care of central venous catheters for total parenteral nutrition.

This report summarizes data obtained via a mailed questionnaire from 129 Department of Veterans Affairs (VA) hospitals regarding current practices in the care of central venous catheters (CVCs) used for total parenteral nutrition (TPN). The size of VA hospitals' acute medical-surgical beds ranged from 14 to 1320 (median 168) beds. Over 6000 patients annually received CVCs for TPN. Hospitals reported using triple-lumen catheters most frequently as their CVC for TPN (80.3%). A povidone-iodine scrub was used to prepare the skin for CVC insertion by 72.6% of reporting hospitals. Sixty percent of hospitals used transparent polyurethane dressings. Care of CVCs varied among hospitals. Catheter-related infection and sepsis rates were within the national average, although < 50% of responding hospitals provided data on these outcomes. The results of this survey point to the need for a national standardized database relative to patients receiving TPN via a CVC.

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In vitro maturation of rabbit reticulocytes. III. Response of lipoxygenase.

Lipoxygenase activity with linoleic acid as substrate and the immunologically detectable amount of lipoxygenase protein were estimated in the course of in vitro maturation of rabbit reticulocytes withdrawn at the sixth day of an experimental bleeding anaemia. With unseparated cell mixture there was a significant increase in the lipoxygenase activity of 67 +/- 15% after a maturation period of 4 h followed by a decrease up to the initial level. The maturational changes were more pronounced when the fraction of youngest reticulocytes after buoyant density separation in a serum albumin gradient was used, whereas the cells of medium density failed to show the intermittent increase. The lipoxygenase activity was largely paralleled by the amount of lipoxygenase protein. The increase of lipoxygenase was prevented by either anaerobiosis or addition of oligomycin. The protein synthesis was greatly decreased after 4 h of incubation. The decline of the amount of lipoxygenase between 4 and 24 h incubation is probably largely caused by proteolysis. The results support former interpretations as to the synthesis and biological dynamics of lipoxygenase in reticulocytes.

Animals↗