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Biomedical subjects

D Barzilai

Publications and source records attributed to D Barzilai.

At least 55 records · Page 3Linked to original sources
PubMed1983

Human pleuropulmonary gnathostomiasis: a case report from Israel.

We report a case of human gnathostomiasis presenting with bilateral pleural effusion and probable pericardial involvement. The diagnosis was made on the basis of the patient's country of origin (Nepal), the course of the disease, marked eosinophilia and the identification of Gnathostoma in a thoracic skin biopsy. The patient responded, presumably, to treatment with diethylcarbamazine (Hetrazan). This case is unique in its presentation and occurrence in Israel (although not necessarily acquired in Israel).

Adult↗
PubMed1983

Electrocardiographic patterns in diabetics without clinical ischemic heart disease.

Resting ECG patterns were studied in 42 young diabetic patients and in 40 matched control subjects. There was no clinical ischemic heart disease in either group. Discriminant analysis showed significant differences between the two groups: diabetics typically had a higher heart rate, a leftward frontal QRS axis, a prolonged corrected QT interval and ST segment and T wave changes. Using resting ECG variables we were able to correctly classify 62 (75%) of the 82 patients studied. The findings support the existence of a nonischemic diabetic cardiopathy.

Adult↗
PubMed1982

Computerized medical decisions in evaluating the diabetes patient.

A system for computer simulation of medical reasoning is described which has been applied to classifying diabetic patients and assessing the complications due to disease. Medical knowledge is formulated into modular, interrelated inference pathways. Each module states the inference and the Boolean combinations of criteria sufficient for confirming or rejecting it. Patient data is compared to the medical logic and a status report is produced which presents the clinical findings, confirmed inferences, the diabetes evaluation score for each body system and request for additional data at the follow-up visit. After initial testing the medical logic was easily updated to fully express medical policy in our clinic. The system provides an objective and consistent method for evaluating the diabetic patient.

Diabetes Complications↗
PubMed1982

Congenital prolongation of Q-T interval: a family study of three generations.

Three generations of a family with the Romano-Ward syndrome are described. Of all the affected members, only 1 was symptomatic, experiencing episodes of syncope proven to be due to polymorphous ventricular tachycardia (PMVT) induced by chlorimipramine treatment for depression. During treatment of an episode of PMVT with lidocaine, the patient developed the 'torsade de pointes' variant of ventricular tachycardia, which progressed to ventricular fibrillation and was successfully treated with electroversion. The hazards of treating these patients with commonly used drugs, the possible etiologies for the Romano-Ward syndrome and its mode of inheritance are discussed.

Aged↗
PubMed1982

Pellagra as the presenting manifestation of Crohn's disease.

An 18-yr-old woman hospitalized with classical signs of pellagra was found to have Crohn's disease of the small and large bowel as well as malabsorption of nicotinic acid and iron. The symptoms of pellagra disappeared after intramuscular treatment with nicotinic acid, while the malabsorption was corrected following steroid therapy for the Crohn's disease. Pellagra should thus be added to the list of complications of Crohn's disease that are secondary to malabsorption. Although this complication seems to be very rare, it may be worthwhile to check for nicotinic acid malabsorption in untreated cases of Crohn's disease in order to determine its real prevalence.

Adolescent↗
PubMed1982

Hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor.

A 50-year-old man, suffering from a large pituitary adenoma and panhypopituitarism, was found to have severely elevated thyrotrophin (thyroid-stimulating hormone [TSH]) levels (greater than 20.2 microunits/mL). The thyroxine (T4) level was low (less than 3.0 micrograms/dL). Thyroid sodium iodide I 131 uptake was low (5% at 24 hours). A TSH test result was normal, with a 24-hour 131I uptake of 52% and a normal-looking thyroid gland on scintiscan. After surgical removal of the pituitary chromphobe adenoma, T4 levels returned to normal (6.8 micrograms/dL) and TSH levels improved substantially (9.0 microunits/mL). Findings from repeated 131I uptake tests were normal (22% at 24 hours). Other pituitary functions improved also. These results suggest that the patient had biologically inactive TSH produced by the tumor. Removal of the tumor probably enabled recovery of the active TSH with the return of normal thyroid uptake and T4 production. Whenever hypothyroidism and high levels of TSH coexist with pituitary dysfunction, a TSH test is needed to distinguish between primary hypothyroidism and hypothyroidism secondary to biologic inactive TSH.

Adenoma, Chromophobe↗
PubMed1982

Adult Still's disease associated with pregnancy.

A 23-yr-old woman in her sixth month of pregnancy presented with the systemic variant of juvenile rheumatoid arthritis (Still's disease). The symptoms included high fever, erythematous evanescent maculopapular rash, hepatosplenomegaly and asymmetric arthritis. During a follow-up period of 1 yr, anti-inflammatory drugs (both steroidal and nonsteroidal) were administered, leading to the eventual disappearance of the patient's complaints. Adult-onset Still's disease reported in the literature is reviewed, and the association of Still's disease with pregnancy is discussed.

Adult↗
PubMed1981

Binding of iodinated rat and ovine prolactins to prolactin receptors and to its antibodies.

Most studies of prolactin receptors in rat tissues have not used the homologous 125I-labeled rat prolactin as tracers, but rather 125I-labeled ovine or human prolactin. We have compared the effect of different methods of iodination on the specific binding of rat and ovine prolactin to sites in the seminal vesicle of rats and the liver of mice post-partum. Ovine prolactin, either iodinated with lactoperoxidase or with mild chloramine-T (10 micrograms), showed 3 times the specific binding of correspondingly-iodinated rat prolactin. This greater sensitivity of rat prolactin to oxidative damage during iodination, as compared with ovine prolactin is further shown by the difference in Sephadex G-100 elution constant of unlabeled and labeled rat prolactin. . This difference was absent in the case of ovine prolactin. Parallel studies of the binding of the labeled hormone to homologous antibody revealed that immunoreactivity of labeled ovine prolactin was not affected by any of the iodination methods. Rat-prolactin immunoreactivity was depressed by lactoperoxidase iodination as compared with chloramine-T iodination. Rat prolactin was also less potent than ovine prolactin in inhibiting the binding of homologous and heterologous labeled hormone to its receptors, to a larger degree than could be expected from the bioassay potency of the various hormone preparations. These results reflect the greater sensitivity to damage of the biologically active site of rat prolactin, as compared with the ovine hormone.

Animals↗
PubMed1981

The acute effect of metoclopramide on plasma prolactin during pregnancy.

The effect of metoclopramide on plasma prolactin levels was studied in 10 women in the second half of pregnancy. The IV injection of 10 mg metoclopramide produces a significant rise in prolactin in 15 minutes, a peak of up to 6.5-fold over basal levels at 30 minutes and a sustained significant elevation for at least 4 hours. The results of this study indicate that maternal plasma protein levels although elevated, are still under inhibitory control and that the prolactin releasing capacity of the pituitary is maintained during pregnancy. The elevated hyperprolactinemia induced by metoclopramide may be of help in investigating the role of prolactin in human pregnancy.

Female↗
PubMed1981

High density lipoprotein and arteriosclerosis. Different patterns in primary hypothyroidism and type IIa hyperlipoproteinemia.

Concentrations of high density lipoprotein (HDL) and its subfractions were contrasted in two groups of patients with hypercholesterolemia and a control group of normocholesterolemic subjects. HDL-cholesterol and HDL-protein were low in patients with Type IIa hyperlipoproteinemia, but elevated in patients with primary hypothyroidism. HDL-3 levels were low whereas those of HDL-2 remained unchanged in patients with Type IIa hyperlipoproteinemia. In contrast, in the hypothyroid patients, HDL-3 remained unchanged, while HDL-2 levels were high. The role of HDL in the development of arteriosclerosis in patients with primary hypothyroidism is therefore questioned. Our findings also suggest that measurement of HDL-cholesterol alone cannot be regarded as an accurate indicator of changes in total HDL concentration in different clinical situations.

Arteriosclerosis↗
PubMed1981

Antibiotic-responsive malabsorption: a tropical sprue-like syndrome in countries with temperate climates.

Antibiotic-responsive malabsorption is prevalent in the tropics, but has been seen only sporadically in countries with temperate climates. We describe a 19-year-old Israeli patient who has never left the country and was hospitalized with shigellosis and malabsorption of fat and D-xylose. A short course of ampicillin reversed the malabsorption. The syndrome of antibiotic-responsive malabsorption in countries with temperate climates may well be underdiagnosed and should be looked for more actively.

Adult↗