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Biomedical subjects

D Bartko

Publications and source records attributed to D Bartko.

At least 37 records · Page 2Linked to original sources
PubMed1989

[The new hemorheologic drug VULM 957 improves cerebral circulation].

The authors investigated the effect of a newly synthetized haemorheological drug VULM 957 for basic haemorheological parameters in vitro and on the cerebral flow in vivo. It was revealed that substance VULM 957 inhibits in a dose-dependent and time-dependent way the platelet aggregation, reduces the viscosity of blood, increases the deformability of red blood cells and increases the cerebral blood flow. Analysis of possible mechanisms of action of VULM 957 indicates that the observed positive haemorheological effects are due to the influence on the fluidity of the platelet and red cell membrane. The increased cerebral blood flow after administration of VULM 957 depends obviously on the reduced viscosity of the blood and the inhibited formation of platelet microaggregates. The presented results justify the assumption that VULM is a perspective substance in the therapy of cerebrovascular diseases.

Amines↗
PubMed1989

[Changes in glucose metabolism before and after the onset of focal cerebral ischemia. II. Production of insulin].

The purpose of the work was to assess the insulin secretion after a glucose load in a group of patients with cerebral infarction and in a group of arteriosclerotic and hypertonic patients, i.e. potential candidates of cerebral infarction. The material comprised 46 patients, incl. 29 with focal cerebral ischaemia and 17 with arteriosclerosis and hypertension. After oral glucose administration plasma insulin was assessed by radiooimmuncassay (IRI). It was revealed that insulinsecretion in the group of hypertonic and arteriosclerotic patients follows the rise of the blood sugar level, the rise is somewhat lower than in the control group but persists longer and returns later to baseline values. Similar but quantitatively more marked changes were refealed also in the group with focal cerebral ischaemia. From the results ensues that a reduced glucose tolerance in patients with cerebral infarction recorded in previous work is not due to an inadequate insulin secretion, i.e. the peripheral glucose metabolism, but indicates rather the ineffectiveness of insulin to restore glucose homeostasis.

Cerebral Infarction↗
PubMed1989

[Vascular headache: circulatory, hemorrheologic, electrophysiologic and psychological aspects].

The aim of the work was to analyze circulatory, rheological, electrophysiological and psychological characteristics of patients with vascular headache, mostly migraine and vasomotor cephalea. The group was formed by 69 patients, mean age 40.4 +/- 9.0 years. It was revealed that: 1. there were no significant changes in rheological properties of blood in the following six parameters: coagulation, viscosity of plasma and blood, platelzo aggregation, of circulating aggregates, 2. there were no significant changes in rCBF (FF,SF,AF and ISI) parameters in the group of patients with bilateral headache but a rising rCBF in unilateral headache, 3. there was a significant reduction of the "peak frequency" in supratrochlear arteries and a significant increase of the flow rate in the intracerebral arteries (a.cerebralis media, a.cerebralis anterior), 42.4% of the patients displayed abnormal but non-specific EEg changes, 5. there was a significant increase of the amplitude of P1 and N2 waves of visual evoked potentials and a non-significant shortening of the latency of wave N1, 6. significant changes were recorded in some psychological parameters, in particular an increase of the score of depressivity, anxiety and neuroticism.

Adult↗
PubMed1989

[Changes in glucose metabolism before and after the onset of focal cerebral ischemia. I. The intravenous glucose tolerance test].

In a group of 22 patients with focal ischemia of the brain and in 11 patients with cerebral arteriosclerosis and vascular hypertension the tolerance to glucose administered by the i.v. route was investigated. The rate of glucose utilization was expressed by a utilization coefficient. The tolerance to i.v. glucose administration is reduced in the group of arteriosclerotic and hypertensive subjects. As a result of acute focal ischemia of the brain it declines even more, as compared with subjects in the control group. In the mean values of the coefficient of glucose utilization a significant difference was recorded between the group of patients with focal ischemia of the brain, as compared with the control group (p less than 0.001) and the group of arteriosclerotic and hypertonic patients, as compared with controls (p less than 0.005). The authors conclude from the results that the reduced glucose tolerance to orally administered glucose in patients with focal ischemia of the brain and their potential candidates in no causal relationship with the variability of intestinal absorption, as similar changes in glucose tolerance were recorded also after intravenous administration.

Glucose↗
PubMed1989

[The significance of longitudinal Holter electrocardiogram monitoring in the differential diagnosis of syncope in elderly patients].

Longitudinal monitoring of the electrocardiogram by Holter's method is indicated in particular for the diagnosis of intermittent dysrhythmia which may be related to the symptom of syncope in elderly patients. Transient dysrhythmia with subsequent cerebral ischemia may be the cause of altered consciousness, vertige, presyncopes, or true syncopes. Transient dysrhythmias may be therefore considered after elimination of other causes of syncopes as their aetiology, in particular in elderly patients and old age groups where organic heart disease is already present. In those instances Holter's ECG is a useful non-invasive examination method which makes it possible to start appropriate treatment, and later by using serial monitoring, it makes it possible to follow up the effectiveness of antiarrhytmic treatment, or to follow up the function of an implanted cardiostimulator (pacemaker).

Aged↗
PubMed1989

[Optimism or pessimism in the treatment of cerebral infarct].

The aim of the study was to analyse the effects of drug and rehabilitation treatment of cerebral stroke. Material consists of 2,500 patients with focal brain ischemia. About three-fourths (68.7%) of patients with cerebral stroke improved receiving complex drug treatment, rehabilitation and psychological care. 54.9% of the whole group of patients had a neurological deficit score below 150, i.e. more than one half of the whole group (n = 2,500) left the hospital practically in good health capable of carrying on in their original occupation. Only 11.9% of patients died, but 48.9%, i.e. practically one half of them showed an extracerebral cause of death. The results of treatment are dependent on age. In the higher age group, the number of deteriorated cases as well as the number of death increases. The results of treatment are dependent on an early initiation of treatment after the onset of brain ischemia. In the 2nd time-period, the results of treatment are better in comparison to the 1st period due to new strategies of treatment, i.e. due to drugs that improve heart failure, rheological properties of the blood and brain metabolism and due to intensive rehabilitation care. The results have shown the improvement not only in movement possibilities of the patients, but also the improvement in majority of the psychological parameters (IQ, emotionality, sociability scale etc.).

Aged↗
PubMed1989

[Is the effect of naloxone on cerebral circulation mediated by blood platelets?].

In an attempt to elucidate the mechanism of action of the opiate antagonist, naloxone, on the cerebral circulation the authors investigated changes of thrombocyte aggregation in whole blood (impedance aggregometry) and in the regional cerebral blood flow (hydrogen "wash-out" method) after a single dose of naloxone (1 mg/kg) to intact gerbils and gerbils with hemispheric cerebral ischemia. Under physiological conditions naloxone significantly reduced the cerebral blood flow and at the same time increased platelet aggregation. Under conditions of hemispheric cerebral ischemia naloxone increased the blood flow but did not affect the platelets activated by ischemia. The authors assume that naloxone induced hyperaggregation of platelets is at least partly responsible for the reduced cerebral blood flow after naloxone administration to intact animals. The favourable effect of naloxone on the ischemic cerebral circulation is, however, certainly not mediated by the effect on the platelet activity.

Animals↗