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Biomedical subjects

D Barnard

Publications and source records attributed to D Barnard.

At least 91 records · Page 5Linked to original sources
PubMed1983

Irradiation of liver metastases due to gestational choriocarcinoma.

One of the major unresolved problems in high-risk choriocarcinoma is the prevention of hemorrhage from tumor necrosis during chemotherapy. The authors report a successfully treated patient who developed intrahepatic bleeding while receiving systemic chemotherapy and concomitant whole liver irradiation. Patients with trophoblastic liver metastases are at risk for bleeding from tumor necrosis during chemotherapy but, because there are few reported cases, the degree of risk cannot be predicted. Radiation therapy for the prevention of this complication may not be as successful for liver metastases as it is for brain metastases; reports are too scarce to evaluate its efficacy. As demonstrated in the present patient, radiation therapy does not completely eliminate the risk of hemorrhage from chemotherapy. The hypothesis that patients with liver metastases from gestational choriocarcinoma are more susceptible to treatment failure and life-threatening complications than other members of the high-risk category needs support. Other investigators are encouraged to report their results with trophoblastic liver metastases to clarify the type and degree of risk, to determine the role of adjuvant radiation therapy, and to establish optimum treatment protocols.

Adult↗
PubMed1982

The squirrel monkey: receptor-mediated end-organ resistance to progesterone?

Fertile females of a New World primate species, the squirrel monkey (Saimiri sciureus), have plasma progesterone concentrations that vary between 57 and 510 ng/ml during the reproductive cycle and are 10- to 20-fold higher than those seen in cynomolgus monkeys (Macaca fascicularis) and other Old World primates, including man. The plasma progesterone level during pregnancy is high and varies between 140 and 490 ng/ml. Estradiol levels during the reproductive cycle and pregnancy are also higher than those of cynomolgus monkeys. After 2-day treatment of ovariectomized monkeys with estradiol in oil, the progesterone receptor content in the uterine cytosol of the squirrel monkey is one eighth that in similarly treated cynomolgus monkeys [60.4 +/- 6.5 fmol R5020 bound/mg protein vs. 496 +/- 55 (mean +/- SE); n = 8]. The receptor affinity for R5020 is the same in both species. Thus, the elevated plasma progesterone levels in squirrel monkeys appear to be a compensatory response to a receptor-mediated decrease in sensitivity to progesterone. The squirrel monkey may be a model for the study of the mechanism of action and regulation of secretion of progesterone.

Animals↗
PubMed1981

Cryoanalgesia in the management of chronic facial pain.

The results of 85 cryogenic nerve blocks in 43 patients with chronic facial pain over a period of 4 years are reviewed. In 67% of patients with non-herpetic neuralgia the duration of pain relief (median 93 days) exceeded the duration of sensory loss (median 60 days).

Cryosurgery↗
PubMed1980

The effects of extreme cold on sensory nerves.

The effects of extreme cold on sensory nerves are discussed and a clinical application of these effects is proposed. The structural changes observed following the freezing of sensory nerves in the rat are described and correlated with the clinical results in patients with chronic facial pain treated by cryogenic peripheral nerve blockade. It is suggested that this technique offers features which are not shown by any other method for interrupting peripheral pain pathways and provides a useful alternative to existing methods of treatment for chronic pain.

Animals↗
PubMed1977

The rate of urine production and the isotope renogram.

The rate of urine production has been measured in a group of normal subjects undergoing renography. It has been helpful in assessing the results. Renograms look unusual at low flow rates and can be misinterpreted if the urine flow rate is not known.

Humans↗
PubMedDate not supplied

Multidisciplinary approach used to improve infant care.

Many of the implemented changes have required the rewriting of standards of care and policies, as well as the education of staff. Staff education was addressed through a variety of approaches, including one-hour inservice training sessions and eight-hour courses. In the final analysis, the multidisciplinary QA committee has had a significant impact on improving the processes involved in caring for infants with RDS. Because of this success, committee members have acknowledged that all aspects of patient care may be examined and changes implemented when caregivers keep an open mind and are willing to change the way "things have always been done." This commitment to examine all aspects of care and to implement change has been, for Presbyterian Hospital, the key to genuine quality improvement. As a result of these and other efforts, Presbyterian Hospital has improved the care given to all of its patients. In March 1992, the hospital received accreditation with commendation.

Ancillary Services, Hospital↗