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Biomedical subjects

D Barcia

Publications and source records attributed to D Barcia.

40 records · Page 3Linked to original sources
PubMedDate not supplied

[Schizophrenia: quality of life and years of evolution].

A study was made of quality of life in schizophrenia depending on years of evolution. In a sample of 100 patients, the quality of life scale of Heinrichs et al. (1984) was used as a measurement instrument for analyzing differences in three study groups (evolution less than five years, six to ten years, over ten years). A progressive decrease occurred in the total scores in three of four CLS categories for schizophrenia of longer duration. In this group, higher scores were obtained in the Instrumental Role category, but the difference was not significant.

Adult↗
PubMedDate not supplied

[A case of Parkinson syndrome secondary to combined amineptine and bromazepam abuse].

A case report of parkinsonism secondary to chronic abuse of amineptine (3 gr/day) and bromazepam (35 mg/day) in a patient diagnosed of borderline personality disorder is presented. The patient did not take any other drugs and he was not recently on neuroleptic treatment; he recognized the abuse of amineptine, as a stimulant, and the bromazepam abuse, looking for a relief to the excessive anxiety secondary to amineptine. The parkinsonism improved after removing both drugs and taking biperiden and diazepam; lastly the patient was discharged without any medication. The patient did not suffer from other complications associated with amineptine or bromazepam abuse. There are some cases reported of parkinsonism secondary to benzodiazepines but there is none secondary to amineptine. We present a short review of the possible responsible mechanisms, thinking on a complex interaction of both drugs on dopamine and its modulatory systems.

Adult↗
PubMedDate not supplied

[Combination of risperidone and serotonergic antidepressants in refractory obsessive-compulsive disorder].

We present the use of risperidone as a potentiation strategy of the serotonergic antidepressants in four patients suffering from refractory obsessive-compulsive disorder. There were an important improvement in three patients. Adding risperidone to serotonergic antidepressants causes complex interactions between serotonergic, dopaminergic and noradrenergic systems, that could lay to the clinical improvement. These and other similar cases make necessary controlled studies. Adding risperidone to serotonergic antidepressants in patients suffering from refractory obsessive-compulsive disorder might be an effective strategy with low risk for secondary effects and without the presence of tics or psychotic symptoms.

Adult↗