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Biomedical subjects

D Ball

Publications and source records attributed to D Ball.

160 records · Page 9Linked to original sources
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Comparative analysis of macromolecules in mollusc shells.

1. Proteins and polysaccharides were isolated from the shells of molluscs; blue mussel, Mytilus edulis, chambered nautilus, Nautilus pompilius, and red abalone, Haliotus rufescens. 2. N-acetyl glucosamine was detected in nautilus but not mussel or abalone. 3. Amino acid analysis of protein fractions was completed for the three molluscs and purified proteins from the mussel were partially sequenced. 4. Calcium binding studies were carried out with some of the protein fractions.

Acetylglucosamine↗
PubMedDate not supplied

Radiation recall reaction following gemcitabine.

A case of dermatitis and myositis in the upper thorax following administration of gemcitabine in a 65-year-old woman with metastatic non small cell lung cancer (NSCLC) is described. The reaction and time course suggest a radiation recall phenomenon. This report joins a small but increasing number of radiation recall events related to gemcitabine. The possibility of a radiation recall reaction should be borne in mind when a patient develops symptoms in a previously irradiated site without evidence of disease progression at that site. Cessation of the precipitating drug is the most important step in management and systemic steroids may hasten symptomatic relief.

Aged↗
PubMedDate not supplied

Role of the GABA(A)beta2, GABA(A)alpha6, GABA(A)alpha1 and GABA(A)gamma2 receptor subunit genes cluster in drug responses and the development of alcohol dependence.

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter of the central nervous system and it acts at the GABA(A) and GABA(B) receptors. A possible role for the GABA(A) receptors in alcohol action has been derived from in vitro cell models, animal studies and human research. GABA(A) subunit mRNA expression in cell models has suggested that the long form of the gamma2 subunit is essential for ethanol enhanced potentiation of GABA(A) receptors, by phosphorylation of a serine contained within the extra eight amino acids. Several animal studies have demonstrated that alterations in drug and alcohol responses may be caused by amino-acid differences at the GABA(A)alpha6 and GABA(A)gamma2 subunits. An Arg(100)/Glu(100) change at the GABA(A)alpha6 subunit conferring altered binding efficacy of the benzodiazepine inverse agonist Ro 15-4513, was found between the AT (alcohol tolerance) and ANT (alcohol non-tolerance) rats. Several loci related to alcohol withdrawal on mouse chromosome 11 which corresponds to the region containing four GABA(A) subunit (beta2, alpha6, alpha1 and gamma2) genes on human chromosome 5q33-34, were also identified. Gene knockout studies of the role of GABA(A)alpha6 and GABA(A)gamma2 subunit genes in mice have demonstrated an essential role in the modulation of other GABA(A) subunit expression and the efficacy of benzodiazepine binding. Absence of the GABA(A)gamma2 subunit gene has more severe effects with many of the mice dying shortly after birth. Disappointingly few studies have examined the effects of response to alcohol in these gene knockout mice. Human genetic association studies have suggested that the GABA(A)beta2, alpha6, alpha1 and gamma2 subunit genes have a role in the development of alcohol dependence, although their contributions may vary between ethnic group and phenotype. In summary, in vitro cell, animal and human genetic association studies have suggested that the GABA(A)beta2, alpha6, alpha1 and gamma2 subunit genes have an important role in alcohol related phenotypes (300 words).

Alcoholism↗
PubMedDate not supplied

Erysipelas in a free-ranging Hawaiian crow (Corvus hawaiiensis).

We describe a case of erysipelas in a free-ranging endangered Hawaiian crow. The partially scavenged carcass exhibited gross emaciation and petechial hemorrhages in both lungs. Microscopy revealed multiple necrotic foci associated with gram-positive rods in the liver and adrenal, diffuse acute proximal tubular necrosis of kidney, diffuse necrosis and inflammation of proventricular mucosa associated with gram-positive rods, and multiple intravascular aggregates of gram-positive rods associated with thrombi. Culture of the kidney revealed the bacterium to be Erysipelothrix rhusiopathiae. The implications of this finding to free-ranging crows remain unclear.

Animals↗
PubMedDate not supplied

Hepatic artery aneurysm.

A 67-year-old man presented with epigastric pain and underwent cholecystectomy for acute acalculus cholecystitis. Exploration revealed a large aneurysm in the hepatic artery. One week later, the patient developed jaundice, ascending cholangitis and common bile duct obstruction. He was treated with percutaneous transhepatic drainage with dramatic improvement, then underwent an emergency aneurysm resection operation. He is now well, 8 months postoperatively. Due to the high mortality rate associated with hepatic artery aneurysm, treatment is primarily surgical with aneurysmorrhaphy or direct arterial reconstruction utilizing either autogenous saphenous vein or prosthetic grafts. For inaccessible aneurysms or when patients are unfit to withstand surgery, embolization is a useful alternative.

Aged↗
PubMedDate not supplied

Chariots of fire.

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Persons with Disabilities↗
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Pay: the nurses verdict.

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Attitude of Health Personnel↗