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Biomedical subjects

D Baker

Publications and source records attributed to D Baker.

At least 379 records · Page 21Linked to original sources
PubMed1973

Nigel John.

Explore the source record for details and available documents.

Delivery, Obstetric↗
PubMed1968

Incidence of gross chromosomal errors among tall criminal American males.

Chromosome studies on 129 tall men surveyed in four different institutions for the care of criminal males in Pennsylvaniia showed that 1 in 11 subjects displayed aneuploidy of the sex chromosomes; specifically, five cases of 47,XYY and seven cases of Klinefelter syndrome were identified. All the aneuploid subjects were mentally ill; none had been cytogenetically diagnosed.

Aneuploidy↗
PubMedDate not supplied

Absorption of labeled triethanolamine salicylate in human and canine knee joints. II.

The transdermal absorption by tissues of salicylate from triethanolamine salicylate (TEA/S) ointment applied to canine and human skin was shown to be consistent, significant, and reproducible. Salicylate levels were measured using thin-layer chromatography, nuclear magnetic resonance, and radiochemistry. Absorption was directly proportional to the concentrations of the active ingredient in the ointment up to the 10 per cent preparation. Tissue salicylate levels were not influenced by the sex of the canine subjects. In humans, the activity of the patients affected both tissue levels and urinary excretion. Autoradiographic and doubly labeled studies suggest that during transdermal absorption of TEA/S, the salt may disassociate; this could permit the salicylate to have a longer transit time in the area of application.

Animals↗
PubMedDate not supplied

Experimental allergic encephalomyelitis raises betaine levels in the spinal cord of strain 13 guinea-pigs.

Chronic relapsing experimental allergic encephalomyelitis, an animal model of multiple sclerosis, was induced in Strain 13 guinea-pigs by subcutaneous injection of spinal cord homogenate and Freund's incomplete adjuvant supplemented with Mycobacterium tuberculosis. High resolution 1H NMR spectra of CNS tissue extracts indicated that the levels of choline metabolites, particularly betaine, were elevated in the spinal cord tissue, the principal site of lesion formation in this guinea-pig strain. The spectra also show that N-acetylated compounds are slightly depleted in the disease. The results are discussed in relation to the biochemical interpretation of NMR spectra obtained in vivo from patients with multiple sclerosis.

Acetylation↗
PubMedDate not supplied

Functional inferences from blind ab initio protein structure predictions.

Ab initio protein structure prediction methods have improved dramatically in the past several years. Because these methods require only the sequence of the protein of interest, they are potentially applicable to the open reading frames in the many organisms whose sequences have been and will be determined. Ab initio methods cannot currently produce models of high enough resolution for use in rational drug design, but there is an exciting potential for using the methods for functional annotation of protein sequences on a genomic scale. Here we illustrate how functional insights can be obtained from low-resolution predicted structures using examples from blind ab initio structure predictions from the third and fourth critical assessment of structure prediction (CASP3, CASP4) experiments.

Computational Biology↗