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Biomedical subjects

D B Stevens

Publications and source records attributed to D B Stevens.

36 records · Page 2Linked to original sources

Traumatic paraplegia in children without contiguous spinal fracture or dislocation.

Traumatic paraplegia in children is uncommon and, in almost half of these injuries, no contiguous fracture or dislocation of the spine is found. This report presents eight such cases, three in detail. Most of the children were injured in motor vehicle accidents and sustained thoracic level injuries with a permanent loss of neurological function caudal to the injury. The clinical presentation and radiological diagnosis are reviewed. Four mechanisms of injury have been proposed: transient vertebral subluxation, transient disc herniation, traction and stretching of the spinal cord, and vascular compromise with infarction. Unless extramedullary spinal cord compression is present, laminectomy is not useful.

Accidents, Traffic↗

The AMA.

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American Medical Association↗

Wastewater reuse.

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New York↗

Use of Ilizarov external fixator to treat joint pterygia.

Joint pterygia are rare conditions characterized by joint-flexion contractures and webbing of the overlying skin and subcutaneous structures. Treatment is difficult because the neurovascular bundle is often displaced into the web, and only moderate success has been reported with past treatment options. A retrospective review was performed on five patients with six involved joints: two antecubital pterygia and four popliteal pterygia. The Ilizarov technique was used for gradual correction of pterygia through the joint (arthrodiastasis). Primary treatment goals included improvement in functional extension, hygiene independence, and cosmesis. Ambulation was also an objective in the patients with popliteal pterygia. For inclusion in this study, a minimum of 2 years' follow-up was required after the device was removed. Preoperative goals were met in four of the six joints. Initial improvement in total arc of motion was noted; however, some regression was common. Complications were frequent, and there was a learning curve for proficiency with the Ilizarov technique. We believe that the Ilizarov technique provides a treatment option for antecubital and popliteal pterygia.

Child↗

Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism.

PURPOSE: To identify the gene causing tarsal/carpal coalition syndrome (TCC). METHODS: Individuals from three kindreds with TCC and normal hearing were used to map TCC and screen for mutations in Noggin (NOG). RESULTS: Three different missense mutations in NOG were found. Two of these mutations are identical to mutations previously reported to cause proximal symphalangism (SYM1). CONCLUSIONS: TCC is allelic to SYM1, and at least two different mutations in NOG can result in either TCC or SYM1 in different families. This finding suggests that phenotypic differences between these conditions are caused by epistatic modifiers of NOG.

Abnormalities, Multiple↗

Idiopathic neurogenic arthropathy.

This is a report of an unusual case of idiopathic neurogenic arthropathy in the lower extremities of a 7-year-old girl. A brief review of the known causes of neurogenic arthropathy is presented.

Arthropathy, Neurogenic↗

Hip abnormalities in children with Charcot-Marie-Tooth disease.

Hip dysplasia was recently observed in association with Charcot-Marie-Tooth disease (CMT). We retrospectively reviewed available radiographs of 74 of 100 children with clinically and electrodiagnostically proven CMT and noted six cases of hip dysplasia. Minor hip abnormalities, most commonly increased neck shaft angles, were noted in 21 other patients. Type I usually causes more weakness and had more hip dysplasia than type II. A female predominance was noted but may have resulted from sampling of more immature radiographs in males. Most dysplasia was asymptomatic and was detected only on screening radiographs.

Adolescent↗

Poland's syndrome in one identical twin.

Female twins were evaluated at the Shriners Hospital in Lexington, Kentucky. One twin was normal, and the other twin had the classic findings of Poland's syndrome, manifested by absence of the pectoralis major and symbrachydactyly of the right upper extremity. Buccal smears from each child were submitted for DNA testing. The test confirmed monozygosity with 99.9% probability. Some previous reports have stated that Poland's syndrome is an autosomal dominant, genetically determined trait, whereas others have maintained that there is no genetic association. The original case described by Poland in 1841 was his cadaver, and no family history was reported. This twin study provides strong evidence that the condition is not determined by gene transmission.

Diseases in Twins↗